DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31198 and erap2

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_005165525.1	Gene:	erap2 / 100144556	ZFINID:	ZDB-GENE-080402-6	Length:	935	Species:	Danio rerio

Alignment Length:	968	Identity:	269/968 - (27%)
Similarity:	451/968 - (46%)	Gaps:	158/968 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LATE-----LNEYRLAEHITPVNYNITLRPYLLETDGNKRFTFDGEVWIEVISNQTTNDIYLHSK 93
            |||:     .::.||..:|.||:|::.:.|.|      ...:|.|.|.||:.....||.:.||||
Zfish    31 LATDGLPFPWSKVRLPNYIVPVHYHLLIHPNL------TTLSFTGSVKIEIDVKNNTNWVVLHSK 89

  Fly    94 NL------------------TYSVREYWQKPTTEVANPTVIQISATNTTNYDTDIVKLTASTALT 140
            ||                  |.||.||.......:.:|.:                       ||
Zfish    90 NLKIYTATVLDEHEAHLSEKTLSVLEYPLHEQIAIFSPKI-----------------------LT 131

  Fly   141 ANTTYILHFVYTGLMEDDMHGFYRSSYVDDNNVTKWLGSTQFQTHHARRAFPSFDEPQFKATFDV 205
            :...|.|:..:...:.|..||||:|:|...:..|:.|.||.|:...||.|.|.||||.|||.:.|
Zfish   132 SGEKYFLYLEFGAPLSDGFHGFYKSTYRTKSGETRVLASTHFEPTSARMALPCFDEPVFKANYTV 196

  Fly   206 TLKRHRTFNSVSNTRLISSYPSTEEGIFSDVYKTTPKMSTYLLAFIISEF-----VARKDDDFGV 265
            .::|..:..::||..|..:. ....|:|.|.::.:.|||:|||||||.:|     :.....:..:
Zfish   197 RIRRGPSHIALSNMPLEQTV-EISNGLFEDHFEASVKMSSYLLAFIICDFKSVSGLTATGINISI 260

  Fly   266 YARPEYYAQTQYPYNVGIQILEEMGQYLDKDYYSMGNDKMDMAAIPDFSAGAMENWGLLTYRERS 330
            ||.||.:.||||.....:::||...||.:..|   ...|:|:.|||||.:||||||||.||||.|
Zfish   261 YAVPEKWHQTQYALEAALRLLEFYEQYFNILY---PLPKLDLIAIPDFESGAMENWGLTTYRETS 322

  Fly   331 LLVDESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSYTWLNEGFARYFQYFGTAMVEDKWEL 395
            ||.|...::.:.:..:..|:.||.||.|||:|||..||:..|||||||||.:......|..:.::
Zfish   323 LLYDPDISSASDKLWVTMVIGHELAHQWFGNLVTMDWWNDIWLNEGFARYMESVSVEAVYPELKV 387

  Fly   396 EKQFVVDQVQSVMAMDSTNATNPLSDENTYTPAHLSRMFNSISYNKGATFIRMIKHTMGEQQFQK 460
            |..| :|.....:..||.|::.|:| ....:|..:..||:::||.|||..:.|::|.:.::.||.
Zfish   388 EDHF-LDTCFGAIGRDSLNSSRPIS-SLAESPTQIKEMFDTVSYEKGACILHMLRHFLTDEGFQS 450

  Fly   461 SLQEYLKKYEYQSSLPEYLLGAW--------QANWPNSSYNESS-----------------KDIF 500
            .:..||:::.|.::..|.|   |        :.::....|..||                 |.:.
Zfish   451 GIIRYLRRFSYCNARNEDL---WDSLIKTCSEEDFAAGEYCYSSAQATKNAYRFAGEHVDLKKMM 512

  Fly   501 KSFTEQVGYPLINVTVGNSQVSFTQKRFL--LKESDGSDSSLK----YTVPISYTTSETNNFLNT 559
            .::|.|.|.||:.|.....::...|:|||  :...|.|..||:    :.:|::|.||.:::.:
Zfish   513 NTWTLQKGIPLVTVKRQGRKLHIGQERFLKIVLPDDPSWHSLQDGYLWHIPLTYKTSHSDHEV-- 575

  Fly   560 TPKFILKPNVTTTVQFNSTIKWIVVNIQQTGYYRVTYSDDNWHAIHHALITANWGGIHENNRAQI 624
              |.||... :..:..:..:.|:.:|....|||.|.|.::.|:|:.. |:..|...:...:||.:
Zfish   576 --KHILDKK-SDVLLLDEHVDWVKLNTDMNGYYIVHYDEEGWNALTE-LLKVNHTALSFKDRASL 636

  Fly   625 VDDLFNLARAGYVTYNLTLDVIEYLQTETNYIPWTSAFNGFNYL----TIRLGNDTADFNYYIQT 685
            :.:.|.|..||.::.:..||:|.||::||:.:|   ...|..||    .:......||..:.::|
Zfish   637 IHNAFQLVTAGRLSLDRALDLIAYLKSETHNVP---LLQGLGYLQSFYKLIEKRKIADVTHNLKT 698

  Fly   686 LTNKAYNQLGFNEASNDTAL--DIYLRTKILSWACRYGSSDCISQAQGYFQS------LATVPKN 742
            ...:.:..:...::.:|..:  |..||..:||.||......|:.:|:..|.|      ..::|.:
Zfish   699 YILQYFKDVIDKQSWSDDGMVSDRRLREDVLSLACDLDYPPCLEKAERLFVSWVKSNGTISLPTD 763

  Fly   743 IRATVYCVG----------LREGGEAEFQALYNKFKNETVATEET-----LLQNSF--GCVKTQS 790
            :..|||.||          ||:.|.:..:...:||.:...:::::     |||...  ..:|||:
Zfish   764 VSETVYMVGAQDDSGWVYLLRQYGVSMCETEKSKFLSALTSSKDSEKLSRLLQLGMEGTVIKTQN 828

  Fly   791 LIEKVFDLIISDEIRRQDKSSVLATLYTENNENVSPVFALVTQKYEELAE--AMGGYSAVATVIS 853
            |...::      .:.|......||             :..|.:.:.||.|  .:|.: .:..:|.
Zfish   829 LPSLIY------MVARNPVGHFLA-------------WDFVKKHWNELVEKFPLGSF-GIREIIV 873

  Fly   854 NIAARFTTNQQLTDLENFNKANGAKFGSSQATLTAAEATVKENLEWATAKLGVFRSYL 911
            ....:|::.::|.::|:|.|:...:....:....|.| .|::|:.|....|...|::|
Zfish   874 GTVTQFSSTEELREVESFFKSIQEQVSQLRIIQVATE-NVEKNIVWLKRNLETMRTWL 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	145/422 (34%)
		M1_APN_2	50..510	CDD:189008	161/507 (32%)
		ERAP1_C	582..898	CDD:288671	78/346 (23%)
erap2	XP_005165525.1	Peptidase_M1	44..432	CDD:279741	145/422 (34%)
		M1_APN_2	52..522	CDD:189008	161/507 (32%)
		ERAP1_C	595..911	CDD:288671	76/340 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12102
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.020