DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31198 and LOC100004744

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_001920418.2	Gene:	LOC100004744 / 100004744	-ID:	-	Length:	935	Species:	Danio rerio

Alignment Length:	949	Identity:	293/949 - (30%)
Similarity:	446/949 - (46%)	Gaps:	93/949 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AVLLVACVSLASAGTRQL----SVDVQPPATLATE-LNEYRLAEHITPVNYNITLRPYLLETDGN 66
            :.:.:.|..|..|....:    :|.:.|......| ..||||.:.:.|..|||||.| .|:.|.:
Zfish     7 SAMCLGCTFLGMASLATIVGLWTVQLLPTTESHVEPWKEYRLPDTLFPHYYNITLWP-RLQPDDH 70

  Fly    67 KRFTFDGEVWIEVISNQTTNDIYLHSKNLTYSVRE-YWQK----PTTEVANPTVIQISATNTTNY 126
            ..:.|.|...:.....:.|:.|.:|...|..:..: |..|    .|:||  |:|.:......|.|
Zfish    71 GLYVFTGNSSVVFKCLRETDIIIIHCNKLNLTSEDGYLAKLSAFSTSEV--PSVKKTWIEEMTQY 133

  Fly   127 DTDIVKLTASTALTANTTYILHFVYTGLMEDDMHGFYRSSYVDDNNVTKWLGSTQFQTHHARRAF 191
                :.|..:..|.|...|:|:..:.|.:.||:.|.|||.| |::...|.:.::|....|||:.|
Zfish   134 ----LVLQLNGKLKAGELYVLYTEFVGELADDLAGLYRSEY-DEDGEKKIVATSQMHPTHARKTF 193

  Fly   192 PSFDEPQFKATFDVTLKRHRTFNSVSNTRLISSYPSTEEG--IFSDVYKTTPKMSTYLLAFIISE 254
            |.||||..||.|.:||...|...::||...|.:..:..:|  :....::.|..||:||||.::|:
Zfish   194 PCFDEPAMKAVFHITLIHDRGTVALSNGMEIENVDTIVDGQPVTVTTFEPTKIMSSYLLALVVSD 258

  Fly   255 FV-------------ARK---DDDFGVYARPEYYAQTQYPYNVGIQILEEMGQYLDKDYYSMGND 303
            :.             |||   :|..|.||           .|:...||:....|.:..|   ...
Zfish   259 YTNVTSADGTLIRIWARKKAIEDGHGDYA-----------LNITGPILKFFENYYNVPY---PLS 309

  Fly   304 KMDMAAIPDFSAGAMENWGLLTYRERSLLVDESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWW 368
            |.|..|:|||..||||||||:.|||.:||.|.:.::.|:::..|.::|||.||||||:|||.|||
Zfish   310 KSDQIALPDFYFGAMENWGLVMYRESNLLYDPTVSSNANKERTATIIAHELAHMWFGNLVTLKWW 374

  Fly   369 SYTWLNEGFARYFQYFGTAMVEDKWELEKQFVVDQVQSVMAMDSTNATNPLS--DENTYTPAHLS 431
            :..|||||||.|..|.|....|..|.::...::..|..|.|:|:..:::|||  :|:...|..:.
Zfish   375 NEVWLNEGFASYVSYLGADFAEPSWNVKDLIILKDVHRVFAVDALASSHPLSSKEEDIIKPEQII 439

  Fly   432 RMFNSISYNKGATFIRMIKHTMGEQQFQKSLQEYLKKYEYQSSLPEYLLGAWQ-----ANWPNSS 491
            ..|:::||:|||:.:||:...:.|..|.:.|..||..:..|:::.|.|   |.     .|...:.
Zfish   440 EQFDTVSYSKGASVLRMLSDFLTEPVFVQGLNTYLTMFADQNTVGEDL---WDHLQTAVNKTGTV 501

  Fly   492 YNESSKDIFKSFTEQVGYPLINVTVGNSQVSFTQKRFLLKESDGSDSSLKYTVPISYTTSETNNF 556
            ...|.|.|...:..|:|:|::.|.....|||  |..|||    ..:|||:.|.|.:|......|:
Zfish   502 LPLSVKVIMDRWVLQMGFPVVTVNTTTGQVS--QMHFLL----DPESSLQRTSPFNYEWIVPINW 560

  Fly   557 LNT---TPKFILKPNVTTTVQFNST-IKWIVVNIQQTGYYRVTYSDDNWHAIHHALITANWGGIH 617
            :.:   ..:|.|...........:| .:|:::|:..||||||.|...||..:.:.| ..|...|.
Zfish   561 MKSKMVQSRFWLLERTAVYNDMKTTGSEWVLLNLNITGYYRVNYDIGNWERLLNQL-AENHKVIS 624

  Fly   618 ENNRAQIVDDLFNLARAGYVTYNLTLDVIEYLQTETNYIPWTSAFNGFNYLTIRLGNDTADFNYY 682
            ..||||||||.||||||..:...|.|....||..|..|:||.||.|..:|..:..  ...:....
Zfish   625 VINRAQIVDDAFNLARAKIIPVTLALKTTTYLSEEREYMPWQSALNNLDYFYLMF--TQTEVYRL 687

  Fly   683 IQTLTNKAYNQL--GFNEASNDTA------LDIYLRTKILSWACRYGSSDCISQAQGYFQSLATV 739
            :|:.|.|....|  .|...:.|.:      .|.|.:...:.:||..|..:|.:....:::.....
Zfish   688 LQSYTKKQVTPLFDYFKTITEDWSDVPSGHTDQYNQVNAIRFACSTGVDECQNLTSSWYKQWMDQ 752

  Fly   740 PK------NIRATVYCVGLREGGEAEFQALYNKFKNETVATEETLLQNSFGCVKTQSLIEKVFDL 798
            |.      |:|:||||..:..||..|:...:..|||  .|.|...|.:|..|.|.|:|:::....
Zfish   753 PNHNPIHPNLRSTVYCSAIATGGAEEWDFGWTMFKN--AAIEADKLMSSLACAKNQTLLKRYLGY 815

  Fly   799 IISDE-IRRQDKSSVLATLYTENNENVSPVFALVTQKYEELAEAMG-GYSAVATVISNIAARFTT 861
            .:... ||:||.:||:..: ..|.:.....:..|..|:|.:....| |....|::||.|...|:|
Zfish   816 TLDPSMIRKQDATSVIVYI-ASNPDGQKLAWEFVRNKWEYMFTEYGVGSFNFASLISGITKTFST 879

  Fly   862 NQQLTDLENFNKANG-AKFGSSQATLTAAEATVKENLEW 899
            ..:|..|..|...|. ..|||:.|.|..|....|.|::|
Zfish   880 EAELEQLLKFKSDNSEIGFGSATAALEQAIEKTKANIKW 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	142/424 (33%)
		M1_APN_2	50..510	CDD:189008	159/489 (33%)
		ERAP1_C	582..898	CDD:288671	102/332 (31%)
LOC100004744	XP_001920418.2	Peptidase_M1	47..450	CDD:279741	142/424 (33%)
		M1_APN_2	57..520	CDD:189008	159/487 (33%)
		ERAP1_C	590..911	CDD:288671	100/326 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020