DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slimp and Sars2

DIOPT Version :9

Sequence 1:	NP_732958.1	Gene:	Slimp / 318604	FlyBaseID:	FBgn0051133	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_076126.2	Gene:	Sars2 / 71984	MGIID:	1919234	Length:	518	Species:	Mus musculus

Alignment Length:	458	Identity:	119/458 - (25%)
Similarity:	180/458 - (39%)	Gaps:	60/458 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 CSRNISALYITG--------DKANENYVTLQPYMDFNKTFGERQFLEQSISSRGLDIR---LETV 71
            ||:|....:.|.        :.|.|.|..| ||:|........:...:|:..|..::|   |..:
Mouse    26 CSQNPRRSFATEKRVRNLLYEHAREGYSEL-PYLDMESVCACPEKAARSLELRKGELRPADLPAI 89

  Fly    72 LSKYEKYKTHHAQLSKVAEERERVTKRLKELTKSGSS-----AVQLEELKEHGKSLRNELKALKQ 131
            :|.:::.:....|:..:..|:|.|.:.::.|..:..|     ..|.:.|:..|:.:|.:|    .
Mouse    90 ISTWQELRQLREQIRSLEAEKEAVAEAVRALLANQDSDQVQKDPQYQGLRARGREIRKQL----T 150

  Fly   132 TLYP----IEDDFIHDYLHLPNLLHVQCPVGGEEKLLYRHGI---PKSENKTTSHL--------A 181
            .|||    :|:......|.|||..|...|||.|.:......:   |....:...||        .
Mouse   151 PLYPQETQLEEQLYQQALRLPNQTHPDTPVGDESQARVVRVVGEKPAFSFQPRGHLEIGEKLDII 215

  Fly   182 RQELVHFVDNNR-YYLMEQAALFDVNAMQSLARYFVNHGHFIQTANPDFVRCVLLEA-----NAT 240
            ||:.:..|..:| |||....||.....:.......|:.| |.....||.:|..:.|.     ||.
Mouse   216 RQKRLSHVSGHRSYYLRGAGALLQHGLVNFTLSKLVSRG-FTPMTVPDLLRGAVFEGCGMTPNAN 279

  Fly   241 PLSDYHL--VQEEHLQNKINTAYLTGGASFESYLGAMTKLCVYPSVLPLRYVCCGRSYNRAEADL 303
            |...|::  .:.|.| |...||.:.....|..:..|...       ||:|.||....| |||.|.
Mouse   280 PSQIYNIDPSRFEDL-NLAGTAEVGLAGYFMDHSVAFRD-------LPVRMVCASTCY-RAETDT 335

  Fly   304 YGPIP-SLYTATQTNAVQIFVATQTDNEADSQ-LEHILNLATDFYKALDIPFRISYATAADLTPA 366
             |..| .||.......|::|..|....|..|| |:..|:|..:....|.:.||:......:|...
Mouse   336 -GKEPWGLYRVHHFTKVEMFGVTGPGLEQSSQLLDEFLSLQVEILTELGLHFRVLDMPTQELGLP 399

  Fly   367 ESIRAVIEVYAPSLQRYVCVGRISNYGDFVSKR--ILFSTRREKHYDFLHMVGGPVLYTSRLIAA 429
            ...:..||.:.|...||..|...||..||.|:|  |:|.|...: ..|.|.|........|::.|
Mouse   400 AYRKFDIEAWMPGRGRYGEVTSASNCTDFQSRRLYIMFETETGE-LQFAHTVNATACAVPRVLIA 463

  Fly   430 LVE 432
            |:|
Mouse   464 LLE 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slimp	NP_732958.1	serS	43..433	CDD:273066	109/425 (26%)
		Seryl_tRNA_N	51..150	CDD:299883	23/110 (21%)
		class_II_aaRS-like_core	194..433	CDD:294192	72/250 (29%)
Sars2	NP_076126.2	PRK05431	67..493	CDD:235461	108/416 (26%)
		Seryl_tRNA_N	67..172	CDD:299883	22/108 (20%)
		SerRS_core	185..485	CDD:238393	79/294 (27%)
		L-serine binding. /evidence=ECO:0000250\|UniProtKB:Q9N0F3	299..301		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..518
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11778
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870