DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slimp and sars1

DIOPT Version :9

Sequence 1:	NP_732958.1	Gene:	Slimp / 318604	FlyBaseID:	FBgn0051133	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_001003882.1	Gene:	sars1 / 445405	ZFINID:	ZDB-GENE-040831-1	Length:	515	Species:	Danio rerio

Alignment Length:	501	Identity:	102/501 - (20%)
Similarity:	195/501 - (38%)	Gaps:	125/501 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AKKTCSRNISALYITGDKANENYVTLQPYMDFNKTFGERQFLEQSISSRGLDIRLETVLSKYEKY 78
            ||..||::|      |:|..:.    :|..|.:....|.|.|| ::::..|.....|
Zfish    56 AKNLCSKSI------GEKMKKK----EPVGDDDTLPEEAQNLE-ALTAETLSPLTVT-------- 101

  Fly    79 KTHHAQLSKVAEERERVTKRLKELTKSGSSAVQLEELKEHGKSLRNELKALKQTLYPIEDDFIHD 143
                 |:.||                    .|.::|..:...|.|.:|:|.:           .:
Zfish   102 -----QIKKV--------------------RVLVDEAVQKTDSDRLKLEAER-----------FE 130

  Fly   144 YL-HLPNLLHVQCPVGGEEKLLYRHGIPKSENKTT------------SHLARQELVHFVD----- 190
            || .:.||||...|:..:|         .::||..            ||:   :||..||
Zfish   131 YLREIGNLLHPSVPISNDE---------DADNKVERTWGDCTVQKKYSHV---DLVVMVDGYEGE 183

  Fly   191 ------NNRYYLMEQAALFDVNAMQSLARYFVNHGHFIQTANPDFVRCVLLEANATPLSD----- 244
                  .:|.|.::...:|...|:.:.|...:...::.....|.|:|..::: ....||.
Zfish   184 KGAIVAGSRGYFLKGPLVFLEQALINYALRILYSKNYNLLYTPFFMRKEVMQ-EVAQLSQFDEEL 247

  Fly   245 YHLV---QEEHLQNKINTAYLTGGASFESYLGAMTK-LCVYPSVLPLRYVCCGRSYNRAEADLYG 305
            |.::   .|:...|.::..||.  |:.|..:.|..: ..:.|..||:||......: |.|...:|
Zfish   248 YKVIGKGSEKSDDNTVDEKYLI--ATSEQPIAAFLRDEWLKPEELPIRYAGLSTCF-RQEVGSHG 309

  Fly   306 -PIPSLYTATQTNAVQIFV-ATQTDNEADSQLEHILNLATDFYKALDIPFRISYATAADLTPAES 368
             ....::...|...::.|| |:..|.::....:.::..|..||:.|.||:||....:..|..|.|
Zfish   310 RDTRGIFRVHQFEKIEQFVYASPHDGKSWEMFDEMIGTAESFYQTLGIPYRIVNIVSGALNHAAS 374

  Fly   369 IRAVIEVYAPSLQRYVCVGRISNYGDFVSKRILFSTRREKHY----DFLHMVGGPVLYTSRLIAA 429
            .:..:|.:.|..|.:..:...||..|:.::|:.....:.|..    :|:||:...:..|:|:|.|
Zfish   375 KKLDLEAWFPGSQAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKAEFVHMLNATMCATTRVICA 439

  Fly   430 LVEH-----GVRLED----------CKLLGSISQKPVHQQDLQQFK 460
            ::|:     |:.:.:          .:::..:...|:.|:..::.|
Zfish   440 ILENFQTEEGIIVPEPLKAFMPPGLTEIIKFVKPAPIDQETTKKQK 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slimp	NP_732958.1	serS	43..433	CDD:273066	89/428 (21%)
		Seryl_tRNA_N	51..150	CDD:299883	17/99 (17%)
		class_II_aaRS-like_core	194..433	CDD:294192	56/253 (22%)
sars1	NP_001003882.1	SerS	3..475	CDD:333239	99/489 (20%)
		Interaction with tRNA. /evidence=ECO:0000250\|UniProtKB:P49591	9..61		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..515		3/11 (27%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:P49591	482..494		1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810