DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and Tie1

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_445997.1	Gene:	Tie1 / 89806	RGDID:	621642	Length:	1137	Species:	Rattus norvegicus

Alignment Length:	743	Identity:	179/743 - (24%)
Similarity:	287/743 - (38%)	Gaps:	175/743 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 HYAVLASEKCFCANVLEPQEQQDEQLCNTRCLAN-KAQYC----GGVGVHSYYSTILTK------ 128
            ||....|...:.|.|::|.|.........|...| :.|..    ||.|... .||::|.
  Rat   484 HYRPQDSMITWSAIVVDPSENVTLMNLKPRTGYNVRVQLSRPGEGGEGAWG-PSTLMTTDCPEPL 547

  Fly   129 -QP--------GPHHLRISNKTENSLTLSWNAYEARKLLLAGGAEAVLPNQLL--DNFLIK---- 178
             ||        ||..||:          ||:                ||:..|  |.||::
  Rat   548 LQPWVESWNVEGPDRLRV----------SWS----------------LPSVPLSGDGFLLRLWDG 586

  Fly   179 AQVLKTYSSLPAFPQPEFMVQSTETQFELTDLHPATLYNISVRAMCKDAQVGQSEC---GQASIE 240
            |:..:...::.: ||....:        ||.|.|.|.|.:.||..         .|   |.||..
  Rat   587 ARGQERRENISS-PQARTAL--------LTGLTPGTHYQLDVRLY---------HCTLLGPASPS 633

  Fly   241 ATTEVGLPSPVPAQPKILSRTDRTVTIELSPIR-------NDNGPLSKLLVIVEYVDNALSQPFD 298
            |  .|.||...|..|:.|    |...:..|.||       ...||:||.:|.:
  Rat   634 A--HVHLPLSGPPAPRHL----RAQALSDSEIRLMWQHPEAPPGPISKYIVEI------------ 680

  Fly   299 AQLLGSWQQAQQDGVPYYIAAELDYDRPEDNRTRRFVVGDGKRYGRFTNKPLDQPDAHVHISLGL 363
                   |.|...|.|.:    :|.|:||:..|....:....||       |.:..|.|.   ||
  Rat   681 -------QVAGGSGDPQW----MDVDKPEETSTTVRGLNASTRY-------LFRVRASVQ---GL 724

  Fly   364 VSTLEGVTKTMYSRGTHDQHVTSLDDFSYATFEKGQSSVVALAVTCVIFGSCL--LLSLIAYFYL 426
            ......|.:|....|.  |..:.:.:...|  |.|....:.|||...:..:||  |.:|:|...:
  Rat   725 GDWSNTVEETTLGNGL--QSASPVQESRVA--EDGLDQQLVLAVVGSVSATCLTILAALLALVCI 785

  Fly   427 RYKTCRGRRLT----GGNTHEMTLQTPIIERENNGYLVEDDPLPHSPENFKQQLQQLVEGYERIP 487
            | ::|..||.|    .|:..|..||.      ::|.|.    |...|:...:.|...|..:|.|
  Rat   786 R-RSCLHRRHTFTYQSGSGEETILQF------SSGTLT----LTRRPKPQPEPLSYPVLEWEDI- 838

  Fly   488 RNALRLNVNDVIGDGRFGEIITGKVSTNDFARDCTLHVLCLDDLNGTTQAQLLRELRQLSQLKRQ 552
                  ...|:||:|.||::|...:..:....:..:.:| .:..:.........||..|.:|...
  Rat   839 ------TFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKML-KEYASENDHRDFAGELEVLCKLGHH 896

  Fly   553 EHLLDFYGVSASPDWFYLIFEQQRM-SLKRKLVESRLMAPSPRL-------TSLSEQLVLQWIYE 609
            .::::..|...:..:.|:..|.... :|...|.:||::...|..       ::||.:.:|::..:
  Rat   897 PNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASD 961

  Fly   610 LASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQQPDH---------NRWLA 665
            .|:.|.|||..|.:||.|.:.:|.|..:...|::.||      ::|.:..:         .||:|
  Rat   962 AANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFG------LSRGEEVYVKKTMGRLPVRWMA 1020

  Fly   666 PEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYVYGDLY 730
            .|.|.:. .::|:|||||...:.||..:||||||.....:  :|.|.:....|..||.....::|
  Rat  1021 IESLNYS-VYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCA--ELYEKLPQGYRMEQPRNCDDEVY 1082

  Fly   731 QLLLNCWQLEPSERSSCEDVAFGVRQLM 758
            :|:..||:..|.||.....:|..:.:::
  Rat  1083 ELMRQCWRDRPYERPPFAQIALQLGRML 1110

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068	10/44 (23%)
		fn3	130..222	CDD:278470	23/105 (22%)
		TyrKc	493..746	CDD:197581	69/269 (26%)
		PTKc	497..750	CDD:270623	69/269 (26%)
Tie1	NP_445997.1	ig	130..211	CDD:278476
		EGF_Lam	228..266	CDD:238012
		EGF_CA	315..346	CDD:238011
		ig	357..442	CDD:278476
		IG_like	370..444	CDD:214653
		fn3	450..530	CDD:278470	11/45 (24%)
		fn3	549..631	CDD:278470	27/125 (22%)
		FN3	643..735	CDD:238020	29/128 (23%)
		PTKc_Tie1	835..1131	CDD:270671	72/293 (25%)
		TyrKc	838..1106	CDD:197581	71/284 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810