Protein Alignment Wsck and Fgfr3

DIOPT Version :9

• Sequence 1: NP_733018.1
• Gene: Wsck / 318600
• FlyBaseID: FBgn0046685
• Length: 791
• Species: Drosophila melanogaster
• Sequence 2: XP_006251452.1
• Gene: Fgfr3 / 84489
• RGDID: 620714
• Length: 804
• Species: Rattus norvegicus
• Alignment Length: 622
• Identity: 130/622 - (20%)
• Similarity: 237/622 - (38%)
• Gaps: 159/622 - (25%)

  Fly   263 RTVTIEL------SPIRNDNGPLSKLLVIVEYVDNALSQPFDAQLLGSW--------QQAQQDGV 313
            :|.|:::      .||.....|.::..|:...|:.......|||....|        .:...||.
  Rat   233 QTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT 297

  Fly   314 PY------YIAAELDYDRPEDNRTRRFVVG--DGKRY-GRFTNKPLDQPDAHVHISLGLVSTLEG 369
            ||      :|:..::    .|.|.|...|.  ||..| .|.||                   ..|
  Rat   298 PYVTVLKSWISENVE----ADARLRLANVSERDGGEYLCRATN-------------------FIG 339

  Fly   370 VTKTMYSRGTH-----DQHVTSLDDFSYATFEKGQ--SSVVALAVTCVIFGSCLLLSLIAYFYLR 427
            |.:..:....|     ::.:..:|       |.|.  :.|::..|...:|  .|:::.:....||
  Rat   340 VAEKAFWLRVHGPQAAEEELMEVD-------EAGSVYAGVLSYGVGFFLF--ILVVAAVTLCRLR 395

  Fly   428 YKTCRGRRLTGGNTHEMTLQTPI-----IERENNGYLVEDDPLPHSPENFKQQLQQLVEGYERIP 487
            ....:|   .|..|.....:.|:     :..|:|..:..:.||        .::.:|..|...:.
  Rat   396 SPPKKG---LGSPTVHKVSRFPLKRQVTVSLESNSSMNSNTPL--------VRIARLSSGEGPVL 449

  Fly   488 RNA---------------LRLNVNDVIGDGRFGEIITGK---VSTNDFARDCTLHVLCL-DDLNG 533
            .|.               .||.:...:|:|.||:::..:   :..:..|:..|:.|..| ||...
  Rat   450 ANVSELELPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATD 514

  Fly   534 TTQAQLLRELRQLSQLKRQEHLLDFYGVSASPDWFYLIFEQQRMSLKRKLVESR----------- 587
            ...:.|:.|:..:..:.:.:::::..|........|::.|.......|:.:.:|
  Rat   515 KDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDA 579

  Fly   588 LMAPSPRLTSLSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMN 652
            ...|..:||...   ::...|::|..|.||:|.:.:||.|.:.:|.||.|..:|::.||
  Rat   580 CRLPEEQLTCKD---LVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFG------ 635

  Fly   653 IARQQPDHN--------------RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAV 703
            :||..  ||              :|:|||.| ....::.:|||||...:.||...|||:||....
  Rat   636 LARDV--HNLDYYKKTTNGRLPVKWMAPEAL-FDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIP 697

  Fly   704 ASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSSCEDVAFGVRQLMTSPRH----- 763
            .  ::|.:.::...|..:||....|||.::..||...||:|.:.:.:...:.:::|....
  Rat   698 V--EELFKLLKEGHRMDKPANCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVTSTDEYLD 760

  Fly   764 -ALSFDRVA-GGLDT----------------LPPYLP 782
             ::.|::.: ||.||                |||..|
  Rat   761 LSVPFEQYSPGGQDTPSSSSSGDDSVFTHDLLPPGPP 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470
		TyrKc	493..746	CDD:197581	70/281 (25%)
		PTKc	497..750	CDD:270623	69/281 (25%)
Fgfr3	XP_006251452.1	IGc2	51..108	CDD:197706
		IG	52..123	CDD:214652
		Ig2_FGFR	155..239	CDD:143265	2/5 (40%)
		IG_like	254..349	CDD:214653	24/117 (21%)
		Ig3_FGFR	262..350	CDD:143175	22/110 (20%)
		PTKc_FGFR3	457..790	CDD:173652	77/346 (22%)
		Pkinase_Tyr	470..746	CDD:285015	70/289 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810