DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Wsck and TEK

DIOPT Version :10

Sequence 1:NP_733018.1 Gene:Wsck / 318600 FlyBaseID:FBgn0046685 Length:791 Species:Drosophila melanogaster
Sequence 2:NP_000450.3 Gene:TEK / 7010 HGNCID:11724 Length:1124 Species:Homo sapiens


Alignment Length:813 Identity:173/813 - (21%)
Similarity:306/813 - (37%) Gaps:191/813 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 HRPIP----IWLSSCLVAMCLGL---PLGAAV-----PQEAPAYYYVGCYTARTDLLHESVYAKT 61
            ||.:|    :|:  |.|....|:   |...:|     |..||.....|...|..::..|..:...
Human   412 HRILPPDSGVWV--CSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDG 474

  Fly    62 PQTCIEICEHQGHHYA----VLASEKCFCANVLEPQEQQDEQLCNTRCLANKAQYCGGVGVH--- 119
            |....::.....:||.    :..:.:....|.|||:.:.  :||..  |..:.:  ||.| |   
Human   475 PIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEY--ELCVQ--LVRRGE--GGEG-HPGP 532

  Fly   120 -SYYSTILTKQPGPHHLRISNKTENSLTLSWNAYEARKLLLAGGAEAVLPNQLLDNFLIKAQVLK 183
             ..::|.....|.|..|.:..|::.:|.|:|              :.:.|:. .|:|.::.:   
Human   533 VRRFTTASIGLPPPRGLNLLPKSQTTLNLTW--------------QPIFPSS-EDDFYVEVE--- 579

  Fly   184 TYSSLPAFPQPEFMVQSTETQFELTDLHPATLYNISVRAMCKDAQVGQSECGQASIEATTEVGLP 248
             ..|:....|....|....|...|.:|||...|.:..|...| ||      |:.| |..|...|.
Human   580 -RRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTK-AQ------GEWS-EDLTAWTLS 635

  Fly   249 SPVPAQPKILSRTDRTVTIELSPIRNDNGPLSKLLVIVEYVDNALSQPFDAQLLGSWQQAQQDGV 313
            ..:|.||:         .|::|.|.:.:..:|..::                          || 
Human   636 DILPPQPE---------NIKISNITHSSAVISWTIL--------------------------DG- 664

  Fly   314 PYYIAAELDYDRPEDNRTRRFVVGDGKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTKTMYS-R 377
             |.|:          :.|.|:.| .||           ..|.||.:.      ::..|.|.|. :
Human   665 -YSIS----------SITIRYKV-QGK-----------NEDQHVDVK------IKNATITQYQLK 700

  Fly   378 GTHDQHVTSLDDF---------------------SYATFEKGQSSVVALAVTCVIFGSCLLLSLI 421
            |...:....:|.|                     |.|..:.|...::.:|:......:||.:.|.
Human   701 GLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLA 765

  Fly   422 AYFYLRYKTCRGRRLTGGNTHEMTLQTPIIERENNGYLVEDDPLPHSPENFKQQLQQLVEGYERI 486
            ....|:.|....:|.. ....:...:.|.:: .|:|.|..:..:.::|:         ...|..:
Human   766 FLIILQLKRANVQRRM-AQAFQNVREEPAVQ-FNSGTLALNRKVKNNPD---------PTIYPVL 819

  Fly   487 PRNALRLNVNDVIGDGRFGEIITGKVSTNDFARDCTL----HVLCLDDLNGTTQAQLLRELRQLS 547
            ..|.::.  .||||:|.||:::..::..:....|..:    .....||     ......||..|.
Human   820 DWNDIKF--QDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDD-----HRDFAGELEVLC 877

  Fly   548 QLKRQEHLLDFYGVSASPDWFYLIFE-QQRMSLKRKLVESRLMAPSPRL-------TSLSEQLVL 604
            :|....::::..|......:.||..| ....:|...|.:||::...|..       ::||.|.:|
Human   878 KLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLL 942

  Fly   605 QWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQQPDH--------- 660
            .:..::|..|:|||..|.:||.|.:.::.|..::..|::.||      ::|.|..:         
Human   943 HFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFG------LSRGQEVYVKKTMGRLP 1001

  Fly   661 NRWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYV 725
            .||:|.|.|.:. .::|.|||||...:.||..:||||||.....:  :|.|.:....|..:|...
Human  1002 VRWMAIESLNYS-VYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCA--ELYEKLPQGYRLEKPLNC 1063

  Fly   726 YGDLYQLLLNCWQLEPSERSSCEDVAFGVRQLM 758
            ..::|.|:..||:.:|.||.|...:...:.:::
Human  1064 DDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WsckNP_733018.1 WSC 42..115 CDD:460348 13/76 (17%)
fn3 130..222 CDD:394996 19/91 (21%)
PTKc 497..750 CDD:270623 73/273 (27%)
TEKNP_000450.3 Ig_Tie2_1 24..118 CDD:463089
EGF_Lam 230..275 CDD:238012
EGF_Lam 314..>342 CDD:238012
IgI_Tie2 348..439 CDD:409556 8/28 (29%)
Ig strand A 348..352 CDD:409556
Ig strand A' 358..362 CDD:409556
Ig strand B 365..374 CDD:409556
Ig strand C 382..387 CDD:409556
Ig strand C' 391..393 CDD:409556
Ig strand D 397..401 CDD:409556
Ig strand E 404..412 CDD:409556 173/813 (21%)
Ig strand F 420..428 CDD:409556 3/9 (33%)
Ig strand G 431..439 CDD:409556 2/7 (29%)
fn3 445..520 CDD:394996 15/78 (19%)
fn3 544..626 CDD:394996 24/107 (22%)
FN3 639..731 CDD:238020 25/156 (16%)
PTKc_Tie2 816..1118 CDD:133219 75/297 (25%)
Blue background indicates that the domain is not in the aligned region.

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