DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wsck and fgfr3

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	XP_021336328.1	Gene:	fgfr3 / 58129	ZFINID:	ZDB-GENE-000816-1	Length:	821	Species:	Danio rerio

Alignment Length:	443	Identity:	94/443 - (21%)
Similarity:	179/443 - (40%)	Gaps:	101/443 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   396 EKGQSSVVALAVTCVIFGSCLLLSLIAYFYLRYKTCRGRRLTGGNTHEMTLQTPIIER------- 453
            |...:.::....:||:|...:::.::...::             || :.||..|.:::
Zfish   377 EDDYADILIYVTSCVLFILTMVIIILCRMWI-------------NT-QKTLPAPPVQKLSKFPLK 427

  Fly   454 -------ENNGYLVEDDPL-----------PHSPENFKQQLQQLVEGYERIPR---NALRLNVND 497
                   |:|..:..:.||           |..|...:.:|..       .|:   ...:|.:..
Zfish   428 RQVTVSLESNSSMNSNTPLVRIARLSSSDGPMLPNVSELELPS-------DPKWEFTRTKLTLGK 485

  Fly   498 VIGDGRFGEIITGK---VSTNDFARDCTLHVLCLDDLNGTTQ--AQLLRELRQLSQLKRQEHLLD 557
            .:|:|.||:::..:   :......:..|:.|..|.| :||.:  :.|:.|:..:..:.:.:::::
Zfish   486 PLGEGCFGQVVMAEAIGIDKEKPNKPLTVAVKMLKD-DGTDKDLSDLVSEMEMMKMIGKHKNIIN 549

  Fly   558 FYGVSASPDWFYLIFEQQRMSLKRKLVESR-----------LMAPSPRLTSLSEQLVLQWIYELA 611
            ..|........|::.|.......|:.:.:|           ...|:..||...   ::...|::|
Zfish   550 LLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKIPNETLTFKD---LVSCAYQVA 611

  Fly   612 SAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQQPDHN--------------R 662
            ..|.||:|.:.:||.|.:.:|.||.|..:|::.||      :||..  ||              :
Zfish   612 RGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFG------LARDV--HNIDYYKKTTNGRLPVK 668

  Fly   663 WLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYVYG 727
            |:|||.| ....::.:|||||...:.||...|||:||.....  ::|.:.::...|..:||....
Zfish   669 WMAPEAL-FDRVYTHQSDVWSYGVLLWEIFTLGGSPYPGIPV--EELFKLLKEGHRMDKPANCTH 730

  Fly   728 DLYQLLLNCWQLEPSERSSCEDVAFGVRQLMTSPRHALSFDRVAGGLDTLPPY 780
            :||.::..||...||:|.:       .|||:......||.......||...|:
Zfish   731 ELYMIMRECWHAVPSQRPT-------FRQLVEDHDRVLSMTSTDEYLDLSVPF 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470
		TyrKc	493..746	CDD:197581	69/282 (24%)
		PTKc	497..750	CDD:270623	68/282 (24%)
fgfr3	XP_021336328.1	IGc2	67..121	CDD:197706
		Ig2_FGFR	173..257	CDD:143265
		Ig3_FGFR-2	280..369	CDD:143266
		PTKc_FGFR3	468..801	CDD:173652	79/338 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810