Protein Alignment Wsck and PTPRM

DIOPT Version :10

• Sequence 1: NP_733018.1
• Gene: Wsck / 318600
• FlyBaseID: FBgn0046685
• Length: 791
• Species: Drosophila melanogaster
• Sequence 2: XP_016881383.2
• Gene: PTPRM / 5797
• HGNCID: 9675
• Length: 1532
• Species: Homo sapiens
• Alignment Length: 699
• Identity: 134/699 - (19%)
• Similarity: 213/699 - (30%)
• Gaps: 270/699 - (38%)

  Fly   103 TRCLANKAQYCGGVGVHSYYSTI--LTKQPGPHHLR--ISNKTENS------LTLSWNAYEARKL 157
            |||             |||..|:  ..:..|...:|  :|..||||      ..||.....:.||
Human   433 TRC-------------HSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKL 484

  Fly   158 LL---AGGAEA-------------VLPNQLLDNFLIKAQVLK-----------------TYSSLP 189
            :|   .|..|:             .:|.:.:.....:.::..                 ||.::.
Human   485 ILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVS 549

  Fly   190 AF-PQPEFMVQS-------TETQFELTDLHPATLYNISVRAMCKDAQVGQSECGQASIEATTEVG 246
            :| |:.:...||       .||.|....|:|.|.|:.::|     |...:.....|:.:.||::.
Human   550 SFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIR-----ASTAKGFGPPATNQFTTKIS 609

  Fly   247 LPS-PVPAQPKILSRTDRTVTIELSPIRNDNGPLSKLLVIVE-----------YVDNALSQPF-- 297
            .|| |.......|::||.|||:.|.|..:...|:|...::||           .:......|.
Human   610 APSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHF 674

  Fly   298 -DAQLLGSWQQAQQDGVPYYIAAELDYDRPEDN--RTRRFVVGDGKRYGRFTNKPLDQPDAHVHI 359
             :|.||.|         .||.|||.    |.|:  ..:.|.:||.|.|..:.|.|| .|.....|
Human   675 QNASLLNS---------QYYFAAEF----PADSLQAAQPFTIGDNKTYNGYWNTPL-LPYKSYRI 725

  Fly   360 SLGLVSTLEGVTKTMYSRGTHDQHVTSLDDFSYATFEKGQSSVVALAVTCVIFGSCLLLSLIAYF 424
            .....|...|.||              :|....||    :::::...:|..
Human   726 YFQAASRANGETK--------------IDCVQVAT----KAAIIVTQLTTP-------------- 758

  Fly   425 YLRYKTCRG-RRLTGGNTHEMTLQTPIIERENNGYLVEDDPLPHSPENFKQQLQQLVEGYERIPR 488
            |:|.....| .:|||..|.:                    |:| .||
Human   759 YIRIAPAAGDGQLTGAATPK--------------------PVP-EPE------------------ 784

  Fly   489 NALRLNVNDVIGDGRFGEIITGKVSTNDFARDCTLHVLCLDDLNGTTQAQLLRELRQLSQLKRQE 553
                                                                         |:.:
Human   785 -------------------------------------------------------------KQTD 788

  Fly   554 HLLDFYGVSASPDWFYLIF-------EQQRMSLKRKLVESRLMAPSPRLTSLSEQLVLQWIYELA 611
            |.:...||.|....|.:||       ::::::.|||...|........:.:..::...:......
Human   789 HTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCD 853

  Fly   612 SAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSV---FGPLPYMNIARQQP--DHNRWLAPE---- 667
            .|.:::.:..:..|.:.|.|.|......|..||   :.|.|::..|...|  |....:|.:
Human   854 EAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFVPTAILVPINDETHTMASDTSSL 918

  Fly   668 VLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAA 716
            |..|.:.....:||                ||...     ||..|||.|
Human   919 VQSHTYKKREPADV----------------PYQTG-----QLHPAIRVA 946

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:460348	3/11 (27%)
		fn3	130..222	CDD:394996	28/140 (20%)
		PTKc	497..750	CDD:270623	38/236 (16%)
PTPRM	XP_016881383.2	MAM	50..207	CDD:214533
		FN3	180..>663	CDD:442628	55/247 (22%)
		ig	217..299	CDD:395002
		fn3	524..599	CDD:394996	15/79 (19%)
		R-PTPc-M-1	947..1236	CDD:350481	134/699 (19%)
		R-PTPc-M-2	1322..1527	CDD:350483