DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and PTPRF

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	XP_005271136.1	Gene:	PTPRF / 5792	HGNCID:	9670	Length:	1922	Species:	Homo sapiens

Alignment Length:	883	Identity:	162/883 - (18%)
Similarity:	270/883 - (30%)	Gaps:	348/883 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 PHHLRISNKTENSLTLSWNAYEARKLLLAGGAEAVLPNQLLD---NFLIKAQVLKTYSSLPAFPQ 193
            |.:|.::..|.::..|:|:                 |..|.:   ..:....|.:..:|     |
Human   923 PQNLHVTGLTTSTTELAWD-----------------PPVLAERNGRIISYTVVFRDINS-----Q 965

  Fly   194 PEFMVQSTETQFELTDLHPATLYNISVRA-----------------------MCKDAQVGQSECG 235
            .|....:|:|:|.||.|.|.|.|:|.|||                       ..|:.:|..:.
Human   966 QELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAM-- 1028

  Fly   236 QASIEATTEV--GLPSPVPAQPKIL---------SRTDRTVTIELSP-------IRN---DNGPL 279
            :.|:..:.||  ...|.||.  |||         ..:.|.:..:|.|       :.|   ..|.|
Human  1029 KTSVLLSWEVPDSYKSAVPF--KILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGL 1091

  Fly   280 SKLLVI--------------VEYVDNA---LSQPF--DAQLL--------------GS-----W- 305
            ..|:.|              ..|:::.   ||.|.  |..|:              ||     |
Human  1092 QHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWS 1156

  Fly   306 -----------------------QQAQQDGVPYYIAAELDYDRPEDNRTRRFVVGDGKRYGRFTN 347
                                   ::.|.:.:..|:||:||. .||     .|.:||.|.|..|.|
Human  1157 TPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDV-LPE-----TFTLGDKKNYRGFYN 1215

  Fly   348 KPLDQPDAHVHISLGLVSTLEGVTKTMYSRGTHDQHVTSLDDFSYATFEKGQSSVVALAVTCVIF 412
            :|| .||......: |.|..|.:.:..|:...:...:.     ...|..:.|.....|.||..:.
Human  1216 RPL-SPDLSYQCFV-LASLKEPMDQKRYASSPYSDEIV-----VQVTPAQQQEEPEMLWVTGPVL 1273

  Fly   413 GSCLLLSLIAYFYLRYKTCRGRRLTGGNTHEMTLQTPI-------IERENNGYLVEDDPLPHSPE 470
             :.:|:.||....|.:|..|....:..:...:.|:..:       :|.....|......:|..|.
Human  1274 -AVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGSSVPSCPN 1337

  Fly   471 NFKQQ------LQQLVEGYERIPRNALRLNVNDVIGDG-----RFGEIITGKVST---------- 514
            ....:      :..|.:..||:..|           ||     .:..|..|:..|
Human  1338 TSSMRDHPPIPITDLADNIERLKAN-----------DGLKFSQEYESIDPGQQFTWENSNLEVNK 1391

  Fly   515 ------NDFARDCTLHVL-CLDDLNGT-------------------TQAQL-------------- 539
                  |..|.|.:..:| .:|.:.|:                   ||..|
Human  1392 PKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQ 1456

  Fly   540 -------LRELRQLSQLKRQEH---------------LLDFYGVSASPDWFYLI----FEQQRMS 578
                   :..|.:.|::|..::               |||...::.     |.:    ..:...|
Human  1457 RTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELAT-----YTVRTFALHKSGSS 1516

  Fly   579 LKRKLVESRLMA---------PSPRLTSLSEQLVLQWIYELASAMNYL-SSCQVVHRQLCSHSV- 632
            .||:|.:.:.||         |:|.|..|..          ..|.|.| :...|||   ||..|
Human  1517 EKRELRQFQFMAWPDHGVPEYPTPILAFLRR----------VKACNPLDAGPMVVH---CSAGVG 1568

  Fly   633 ----FVTSDFKLK-------LSVFGPLPYMNIARQQPDHNRWLAPEVLRHQHHHSTRSDVWSLAC 686
                |:..|..|:       :.::|.:..|                  |.|.::..:::
Human  1569 RTGCFIVIDAMLERMKHEKTVDIYGHVTCM------------------RSQRNYMVQTE------ 1609

  Fly   687 VAWECCALGGTPYANAVASNQQLLEAIRAAVR--PAQPAYVYGDLYQLLLNCWQLEPSERSSCED 749
                         ...|..::.||||......  ||:      :||..:....|:.|.|..:..:
Human  1610 -------------DQYVFIHEALLEAATCGHTEVPAR------NLYAHIQKLGQVPPGESVTAME 1655

  Fly   750 VAFGVRQLMTSPRHALSF-------DRVAGGLDTLPPY 780
            :.|  :.|.:|..|...|       ::....|..:.||
Human  1656 LEF--KLLASSKAHTSRFISANLPCNKFKNRLVNIMPY 1691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470	22/92 (24%)
		TyrKc	493..746	CDD:197581	59/357 (17%)
		PTKc	497..750	CDD:270623	59/357 (17%)
PTPRF	XP_005271136.1	I-set	33..124	CDD:254352
		Ig	50..121	CDD:143165
		I-set	135..225	CDD:254352
		Ig2_RPTP_IIa_LAR_like	152..226	CDD:143215
		IG_like	242..319	CDD:214653
		Ig3_RPTP_IIa_LAR_like	250..318	CDD:143216
		FN3	323..412	CDD:238020
		FN3	419..511	CDD:238020
		FN3	516..605	CDD:238020
		fn3	613..700	CDD:278470
		FN3	714..820	CDD:238020
		FN3	825..914	CDD:238020
		FN3	923..1011	CDD:238020	24/109 (22%)
		FN3	1020..>1079	CDD:238020	14/62 (23%)
		PTPc	1366..1621	CDD:214550	47/309 (15%)
		PTPc	1392..1621	CDD:238006	44/283 (16%)
		PTPc	1657..1912	CDD:214550	8/37 (22%)
		PTPc	1682..1912	CDD:238006	3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900