DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wsck and PTPRE

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	XP_024303860.1	Gene:	PTPRE / 5791	HGNCID:	9669	Length:	731	Species:	Homo sapiens

Alignment Length:	510	Identity:	94/510 - (18%)
Similarity:	172/510 - (33%)	Gaps:	154/510 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 YGRFTNKPLDQPDAHVHISLGLVSTLEGVTKTMYSRGTHDQHVTSLDDFSYATFEKGQSSVVALA 406
            :.|.|.:|| .|...|..||.|...|.|      :..|.|.:.|:.   :....:.|.|..:...
Human    27 FPRSTMEPL-CPLLLVGFSLPLARALRG------NETTADSNETTT---TSGPPDPGASQPLLAW 81

  Fly   407 VTCVIFGSCLLLSLIAYFYLRYKTCR-------GRRLTGGNTHEMTLQ-TPIIERENNG---YLV 460
            :...:....|:|.|.|||: |::..|       .:::..|...|...| ..::.|..:|   |.
Human    82 LLLPLLLLLLVLLLAAYFF-RFRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYF- 144

  Fly   461 EDDPLP--HSPENFK----QQLQQLVEGYERIPRNALR-----LNVNDVIGDGRFGEIITGKVST 514
               |:|  |..|..:    ...:|..|.:..:|...::     .|..:.....|:..|:     .
Human   145 ---PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNIL-----P 201

  Fly   515 NDFARDCTLHVLCLDDLNGTTQAQLL--------RELRQL--SQLKRQEHLLDFYGVSASPDWFY 569
            ||.:|      :.|..|:|...:..:        :|..:.  :|..:||.:.||:         .
Human   202 NDHSR------VILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFW---------R 251

  Fly   570 LIFEQQRMSLKRKLVESRLMAPSPRLTSLSEQLVLQ----------WIYELASAMNYLSSCQVVH 624
            :::||:..::             ..||:|.|:...:          |.|.              :
Human   252 MVWEQKSATI-------------VMLTNLKERKEEKCHQYWPDQGCWTYG--------------N 289

  Fly   625 RQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQQPDHNRWLAPEVLRHQHHHS------------- 676
            .::|.....|..|:.::.....|        |.||..:  ||.::...|..|
Human   290 IRVCVEDCVVLVDYTIRKFCIQP--------QLPDGCK--APRLVSQLHFTSWPDFGVPFTPIGM 344

  Fly   677 --------TRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIR--------AAVRPAQPAYV 725
                    |.:.|.:...|......:|.|.....:.:...::.|.:        :.:|..:|..|
Human   345 LKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMV 409

  Fly   726 YGD-----LYQLLLNCWQLEPSERSSCEDVAFGVRQLMTSPRHALSFDRVAGGLD 775
            ..|     :||.||..:....:|.    ||:...:.|.|.......||::  ||:
Human   410 QTDMQYTFIYQALLEYYLYGDTEL----DVSSLEKHLQTMHGTTTHFDKI--GLE 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470
		TyrKc	493..746	CDD:197581	49/306 (16%)
		PTKc	497..750	CDD:270623	48/306 (16%)
PTPRE	XP_024303860.1	PTPc	165..424	CDD:214550	50/315 (16%)
PTPRE	XP_024303860.1	PTPc	484..719	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900