DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and PTPRD

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_001364887.1	Gene:	PTPRD / 5789	HGNCID:	9668	Length:	1932	Species:	Homo sapiens

Alignment Length:	508	Identity:	103/508 - (20%)
Similarity:	158/508 - (31%)	Gaps:	207/508 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 PHHLRISNKTENSLTLSWNAYEARKLLLAGGAEAVLPNQLLDNFLIKAQVLKTYSSLPAFPQPEF 196
            |.:|.....|..|:.|||.             ..||..:  :..:.|..:|....::|..|..:.
Human   922 PQNLHSEGTTSTSVQLSWQ-------------PPVLAER--NGIITKYTLLYRDINIPLLPMEQL 971

  Fly   197 MVQSTETQFELTDLHPATLYNISVRAMCKDAQVGQSECGQASIEATTEVGLPSPVPAQPKILSRT 261
            :|.: :|...||.|.|.|.|::.||                   |.|..|   |.|..|.:..||
Human   972 IVPA-DTTMTLTGLKPDTTYDVKVR-------------------AHTSKG---PGPYSPSVQFRT 1013

  Fly   262 ---DRTV-------------TIELS---PIRNDNGPLSKLLV----IVEYVDNALSQPFDAQL-- 301
               |:.|             ::.||   |...::....|:|.    :||.||...:|.....|
Human  1014 LPVDQAVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKP 1078

  Fly   302 --------------LGSWQ--------------------QAQQDG--------VP-------YYI 317
                          .|..|                    :...||        ||       |||
Human  1079 EKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYI 1143

  Fly   318 --------------------AAELDYDRPEDNRTRR------------------------FVVGD 338
                                ..|||....|.:|.||                        |.:||
Human  1144 IIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGD 1208

  Fly   339 GKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTKTMYSRGTHDQHVTSLD-DFSYATFEKGQSSV 402
            .|.||.||||.|.....:|..   :::.:|.....||:...:...|.|:| |....|.|:.....
Human  1209 DKHYGGFTNKQLQSGQEYVFF---VLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIW 1270

  Fly   403 VALAVTCVIFGSCLLLSLIAYFYLRYKTCR---------GRRLTGGNTHE--------------M 444
            |...|..|:|..|:::::     |.||:.:         .|:.:..|..|              :
Human  1271 VVGPVLAVVFIICIVIAI-----LLYKSSKPDRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRL 1330

  Fly   445 TLQTPIIERENNGY--------LVEDDPLPHSPENFKQQLQQLVEGYERIPRN 489
            ..|||  ..:::||        :....|:|         :.:|.:..||:..|
Human  1331 NFQTP--GSDDSGYPGNLHSSSMASHPPIP---------ILELADHIERLKAN 1372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470	22/89 (25%)
		TyrKc	493..746	CDD:197581
		PTKc	497..750	CDD:270623
PTPRD	NP_001364887.1	I-set	24..115	CDD:400151
		Ig strand A'	32..36	CDD:409353
		Ig strand B	39..48	CDD:409353
		Ig strand C	54..59	CDD:409353
		Ig strand C'	62..65	CDD:409353
		Ig strand D	68..75	CDD:409353
		Ig strand E	76..86	CDD:409353
		Ig strand F	94..102	CDD:409353
		Ig strand G	105..115	CDD:409353
		IgI_2_RPTP_IIa_LAR_like	127..226	CDD:409400
		Ig strand B	143..147	CDD:409400
		Ig strand C	156..160	CDD:409400
		Interaction with IL1RAPL1. /evidence=ECO:0000250	180..189
		Mini-exon peptide A9, sufficient for interaction with IL1RAPL1. /evidence=ECO:0000250\|UniProtKB:Q64487	181..189
		Ig strand E	190..194	CDD:409400
		Ig strand F	204..209	CDD:409400
		Ig strand G	216..219	CDD:409400
		Mini-exon peptide B, required for interaction with SLITRK2 and in the function in pre-synaptic differentiation, Acts as an adjustable linker to control relative positions and orientations of the PTPRD second and third immunoglobilin domains for their simultaneous interactions with the first immunoglobilin domain of IL1RAPL1 and IL1RAP, Modulates affinity for IL1RAPL1 and IL1RAP. /evidence=ECO:0000250\|UniProtKB:Q64487	227..230
		IgI_3_RPTP_IIa_LAR_like	239..320	CDD:409401
		Ig strand B	253..257	CDD:409401
		Ig strand C	266..270	CDD:409401
		Ig strand E	287..291	CDD:409401
		Ig strand F	299..304	CDD:409401
		Ig strand G	312..315	CDD:409401
		FN3	323..412	CDD:238020
		FN3	419..511	CDD:238020
		FN3	516..604	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..623
		FN3	612..706	CDD:238020
		FN3	713..819	CDD:238020
		FN3	824..919	CDD:238020
		FN3	922..1013	CDD:238020	29/128 (23%)
		FN3	1023..>1084	CDD:238020	11/60 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1304..1324		3/19 (16%)
		R-PTPc-D-1	1354..1637	CDD:350472	6/28 (21%)
		Substrate binding. /evidence=ECO:0000250	1573..1579
		R-PTP-D-2	1638..1929	CDD:350476
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900