DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and kdr

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_001019824.2	Gene:	kdr / 554230	ZFINID:	ZDB-GENE-041001-112	Length:	1357	Species:	Danio rerio

Alignment Length:	925	Identity:	167/925 - (18%)
Similarity:	310/925 - (33%)	Gaps:	338/925 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MECGSHSGHRPIPI---WL--SSCLVAMCLGLPLGAAVPQEAPAYYYVGCYTARTDLLHE-SVYA 59
            :.|....|..|:.|   |:  ..|.|..   ||.......:...:..:...|.:..|:.: ||..
Zfish   455 LTCTGSGGSSPVTIKWQWMPREDCPVRF---LPKSDPSMAKCDKWREMSNNTGKNPLISQTSVDE 516

  Fly    60 KTPQT--CIEICEHQGHHYAVLASEKCFCANVL-----------------------EPQEQQDEQ 99
            :|.:|  .::|.:...|     |..:|...|.:                       .|.|.||..
Zfish   517 RTLKTISTLKIQKAVDH-----ALYRCIATNKMGQDQRVIVFQVTRFLNLSVLPSSSPIEGQDVI 576

  Fly   100 LCNTRCLANKAQYCGGVGVHSY-YSTILTKQPGP-----HHLRISNKTENSLTLSWNAYEARKLL 158
            :   ||:|::..|   ..:..| .:.:....|.|     ..|.:|:..:.::|:|  ..:...:.
Zfish   577 M---RCVADRLLY---YNLRWYRVANVANHDPPPAAVPCDTLTLSHLHQPNVTVS--GLQGTNVT 633

  Fly   159 LAGGAEAVLPN-QLLDNFLIKAQVLKTYSSLPAFPQPEFMVQSTETQFELTDLHPATLYNISVRA 222
            |    :..:|| .::|..|...||             |.:..:.:|         ..|:|:.:||
Zfish   634 L----DMPIPNATMMDQGLYACQV-------------EIVGTNEKT---------CLLHNLRLRA 672

  Fly   223 M--------CKDAQVGQSECGQASIEATTEV-GLPSPVPAQPK-----------ILSRTDRTVTI 267
            :        ..|.:|..|:    |.....|| |.|:|.....|           ||.|::|.:||
Zfish   673 LEMSRIVTNLTDQRVNVSD----STTLVCEVSGTPTPTIVWTKDNQTVMEGSGVILKRSNRVLTI 733

  Fly   268 ELSPIRNDNGPLSKLLVIVEYVDNALSQPFDAQLLGSWQQAQQDGVPYYIAAELDYDRPEDNRTR 332
                                                  |:.:::....||....:....|.:..|
Zfish   734 --------------------------------------QRVKKEDSGLYICTACNQQGCESSEAR 760

  Fly   333 RFVVGDGKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTKTMYSRGTHDQHVTSLDDFSYATFEK 397
            ..|.|                 |...:::.|:..:..|...|:
Zfish   761 ISVDG-----------------AEEKMNVELIMPIGAVVIAMF---------------------- 786

  Fly   398 GQSSVVALAVTCVIFGSCLLLSLIAYFYLRYKTCRGRRLTGGNTHEMTLQTPIIERENNGYL--- 459
                                |.|:..|.:|.:    :|...|:     |:|        |||
Zfish   787 --------------------LWLLIVFVIRNR----KRPNDGD-----LKT--------GYLSII 814

  Fly   460 VEDDPLPHSPENFKQQLQQLVEGYERI---------PRNALRLNVNDVIGDGRFGEIITGKVSTN 515
            ::.|.:|            :.|..||:         ||:  ||.:.:.:|.|.||:::.......
Zfish   815 LDSDDMP------------MDEHCERLTYDASKWEFPRD--RLKLGEPLGRGAFGQVVEATAYGI 865

  Fly   516 DFARDC-TLHVLCLDDLNGTTQAQ---LLRELRQLSQLKRQEHLLDFYGVSASPDWFYLIFEQ-- 574
            :.|..| |:.|..|.:  |.|.::   |:.||:.|..:....::::..|.........::..:
Zfish   866 EKATTCTTVAVKMLKE--GATSSEYRALMSELKILIHIGHHLNVVNLLGACTKQGGPLMVIVEYC 928

  Fly   575 -----------------------QRMSLKRKLVESR-------LMAPSPRL-------------- 595
                                   .||..:|::.:..       .:..|.||
Zfish   929 KHGNLSSYLKSKRGEYSPYKKRTPRMPNRREVQQDEDPREGDLGLGTSTRLDICTGTAVCTRTGE 993

  Fly   596 ---TSLSEQL------------VLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVF 645
               |:|.::.            ::.:.:::|..|.:|:|.:.:||.|.:.::.::.:..:|:..|
Zfish   994 QTSTTLQDEQESSDWDHLTMEDLISYSFQVAKGMEFLASRKCIHRDLAARNILLSENSVVKICDF 1058

  Fly   646 GPLPYMNIAR---QQPDHNR---------WLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTP 698
            |      :||   :.||:.|         |:|||.: ....::|:|||||...:.||..:||.:|
Zfish  1059 G------LARDVYKDPDYVRKGDARLPLKWMAPETI-FDRVYTTQSDVWSFGVLLWEIFSLGASP 1116

  Fly   699 YANAVASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSSCEDVAFGVRQLMTSPRH 763
            |. .|..::.....::...|...|.|...::||.:|:||...|.:|.:       ..||:....:
Zfish  1117 YP-GVCIDESFCRRLKEGTRMRAPDYATPEIYQTMLDCWLDRPLDRPT-------FTQLVEHLGN 1173

  Fly   764 ALSFDRVAGGLDTLP 778
            .|.......|.|.:|
Zfish  1174 LLQASAQQDGKDYIP 1188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068	19/98 (19%)
		fn3	130..222	CDD:278470	17/97 (18%)
		TyrKc	493..746	CDD:197581	67/329 (20%)
		PTKc	497..750	CDD:270623	66/329 (20%)
kdr	NP_001019824.2	Ig_2	143..221	CDD:290606
		IG_like	233..331	CDD:214653
		Ig	241..335	CDD:299845
		IG_like	345..429	CDD:214653
		Ig2_VEGFR-2	356..429	CDD:143272
		IG	571..654	CDD:214652	21/107 (20%)
		Ig	571..654	CDD:299845	21/107 (20%)
		I-set	677..763	CDD:254352	21/127 (17%)
		IGc2	691..753	CDD:197706	16/103 (16%)
		PKc_like	835..1178	CDD:304357	73/361 (20%)
		Pkinase_Tyr	843..1171	CDD:285015	69/344 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	944..975		3/30 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1296..1357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900