Protein Alignment Wsck and PDGFRA

DIOPT Version :10

• Sequence 1: NP_733018.1
• Gene: Wsck / 318600
• FlyBaseID: FBgn0046685
• Length: 791
• Species: Drosophila melanogaster
• Sequence 2: NP_001334757.1
• Gene: PDGFRA / 5156
• HGNCID: 8803
• Length: 1114
• Species: Homo sapiens
• Alignment Length: 803
• Identity: 166/803 - (20%)
• Similarity: 280/803 - (34%)
• Gaps: 277/803 - (34%)

  Fly   116 VGVH--SYYSTILTKQPGPHHLRISNKTENSLTLSWNAYEAR---------------KLLLAGGA 163
            |.:|  .::...:...|.|   ||| ..:|:|||..|..|..               ||:.|...
Human   352 VNLHEVKHFVVEVRAYPPP---RIS-WLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEE 412

  Fly   164 EAVLPNQLLDNFLIKAQ---VLKTYSSLPAFPQPEFMVQSTETQFELTDLHPATLYNISVRA--- 222
            ::       .::.|.||   .:|:|:.       |.:.|...:..:|.|.|..:....:||.
Human   413 DS-------GHYTIVAQNEDAVKSYTF-------ELLTQVPSSILDLVDDHHGSTGGQTVRCTAE 463

  Fly   223 ----------MCKDAQVGQSECGQ----------------------------ASIEATTEVGLPS 249
                      :|||.:...:|...                            |.:|.|..|..
Human   464 GTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRC-- 526

  Fly   250 PVPAQPKILSRTDRTVTIELSPIRNDNGPLSKLLVIVEYVDNALSQPFDAQLLGSWQQAQQ---- 310
               ....:|...:|.:.:....:|::....:.:||::..|..:|     ..|:..|:|..:
Human   527 ---LAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVIISL-----IVLVVIWKQKPRYEIR 583

  Fly   311 ---------DGVPY-YI-AAELDYDR----PEDNRTRRFVVG--------DGKRYGRFTNKP--- 349
                     ||..| |: ..:|.||.    |.|......|:|        :|..||...::|
Human   584 WRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMK 648

  Fly   350 ----LDQPDAHVHISLGLVSTLEGVTKTMYSRGTHDQHVTSLDDFSYATFEKGQSSVVALAVTC- 409
                :.:|.|.......|:|.|    |.|...|.|                   .::|.|...|
Human   649 VAVKMLKPTARSSEKQALMSEL----KIMTHLGPH-------------------LNIVNLLGACT 690

  Fly   410 ------VIFGSCLLLSLIAYFYLRYKTCRGRRLTGGNTHEMTLQTPIIERENNGYLVEDDPLPHS 468
                  :|...|....|:.|.:..                                 .|..|.|.
Human   691 KSGPIYIITEYCFYGDLVNYLHKN---------------------------------RDSFLSHH 722

  Fly   469 PENFKQQLQQLVEGYERIPRNALRLNVNDVIGDGRFGEIITGKVSTNDFARDCTLHVLCLDDLNG 533
            ||..|::|                    |:.|.....|      ||..:.      :|..:: ||
Human   723 PEKPKKEL--------------------DIFGLNPADE------STRSYV------ILSFEN-NG 754

  Fly   534 ---------TTQAQLLRELRQLSQLKRQEHLLDFYGVSASPDWFYLIFEQQRMSLKRKLVES--- 586
                     |||        .:..|:|:|       ||...|....::::.....|:.:::|
Human   755 DYMDMKQADTTQ--------YVPMLERKE-------VSKYSDIQRSLYDRPASYKKKSMLDSEVK 804

  Fly   587 RLMAP--SPRLTSLSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLP 649
            .|::.  |..||.|.   :|.:.|::|..|.:|:|...|||.|.:.:|.:.....:|:..||
Human   805 NLLSDDNSEGLTLLD---LLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFG--- 863

  Fly   650 YMNIARQ-QPDHN-----------RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANA 702
               :||. ..|.|           :|:|||.: ..:.::|.|||||...:.||..:||||||...
Human   864 ---LARDIMHDSNYVSKGSTFLPVKWMAPESI-FDNLYTTLSDVWSYGILLWEIFSLGGTPYPGM 924

  Fly   703 VASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSSCEDVAFGVRQLMTSPRHALSF 767
            :. :......|::..|.|:|.:...::|::::.||..||.:|.|...::..|..|:.. ::..|:
Human   925 MV-DSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPG-QYKKSY 987

  Fly   768 DRVAGGLDTLPPYLPQLEAVATM 790
            :::  .||.|....|   |||.|
Human   988 EKI--HLDFLKSDHP---AVARM 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:460348
		fn3	130..222	CDD:394996	25/109 (23%)
		PTKc	497..750	CDD:270623	71/278 (26%)
PDGFRA	NP_001334757.1	Ig_3	53..125	CDD:464046
		IgI_PDGFR-alphabeta	237..335	CDD:409447
		Ig strand A	237..241	CDD:409447
		Ig strand A'	248..252	CDD:409447
		Ig strand B	254..263	CDD:409447
		Ig strand C	268..273	CDD:409447
		Ig strand C'	276..278	CDD:409447
		Ig strand D	282..290	CDD:409447
		Ig strand E	294..302	CDD:409447
		Ig strand F	312..318	CDD:409447
		Ig strand G	323..329	CDD:409447
		Ig4_PDGFR	338..438	CDD:409445	22/103 (21%)
		PTKc_PDGFR_alpha	580..981	CDD:173653	111/515 (22%)