DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and Tie

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster

Alignment Length:	774	Identity:	143/774 - (18%)
Similarity:	246/774 - (31%)	Gaps:	263/774 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 QVLKTYSSLPAFPQPEFMVQSTETQFELTDLHPATLYNISVRAMCKDAQVGQSEC-----GQASI 239
            |.||...|..|.|....:||.....       .:|...|:|.:..::..|||:|.     ...:.
  Fly   463 QDLKQTESEVAKPVVRRVVQKVSPS-------SSTPLIITVLSAEEETTVGQTEALPTDESTTTT 520

  Fly   240 EATTEVGLPS-----------PVPA--------QPKILSRTDRTVTIELSPIRNDNGPLSKLLVI 285
            ..||....||           |||:        .|...:.|..|.|...:|........|..::.
  Fly   521 STTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVIP 585

  Fly   286 VEYVDNALSQPFDAQLLGSWQQAQQDGVPYYIAAELDYDRPEDNRTRRFVVGDGKRYGRFTNKPL 350
            .....|::.:. |.:|:.:...|                     .||...:.|......|.|...
  Fly   586 TTTKANSIIEK-DKELIRALGPA---------------------LTREINIDDANNLIVFCNNTS 628

  Fly   351 D---------QPDAHVHISLGLVST--LEGVTKTMYSRGTHDQHVTS------------------ 386
            |         ||......|..::.|  |..:..|::.|.|.....||
  Fly   629 DCGVTPRTQTQPSHTTDSSPKILRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEVYI 693

  Fly   387 --LDDFSYATFEKGQSSVVA------------------LAVTCVIFGSCLLLSLIAYFYLRYKTC 431
              ::..|.|:.....|:|:|                  |....||..:.::|.|:..|.:|
  Fly   694 GIVESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIR---- 754

  Fly   432 RGRRLTGGNTHE--MTLQTPI--IERENNGYLVEDDP----------LPHSPENFKQQLQQ---- 478
              ||.......:  :|.|.||  :::.::.|.|:||.          :.|...:...|..|
  Fly   755 --RRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQA 817

  Fly   479 ------------------------LVEGYERIPRNALRLNVNDVIGDGRFGEIITGKVSTNDFAR 519
                                    |...:....|:.:||  ..::|:|.||::...:.
  Fly   818 MPMSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRL--KSLLGEGNFGQVWKAEA------- 873

  Fly   520 DCTLHVLCLDDLNG----------------TTQAQLLRELRQLSQLKRQEHLLDFYGVSASPDWF 568
                     |||:|                :.|..|..|...:.:|...::::...|.....:..
  Fly   874 ---------DDLSGHFGATRIVAVKTIRACSAQVSLKDEANIMRKLGSHQNVVTLLGACVESEPH 929

  Fly   569 YLIFEQ----QRMSLKRKLVESRLMAPSP-----RLTSLSEQLVLQWIYELASAMNYLSSCQVVH 624
            .||.|.    :.:||.|....:..:.|:.     .|..||.:.:..:..::|..|.|::..::||
  Fly   930 MLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVH 994

  Fly   625 RQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQQPD-----------HN----------------- 661
            |.|.:.:|.:..:...|:..||....::..|.:.:           ||
  Fly   995 RDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHW 1059

  Fly   662 ---------------------------------------RWLAPEVLRHQHHHSTRSDVWSLACV 687
                                                   ||:|||.|:: |..:|.:|:|:...|
  Fly  1060 QHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQY-HMFTTETDIWAFGIV 1123

  Fly   688 AWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSS 746
            .||...||.|||:.  .:.::::..:...:||..|.....:.|.|:..||..||..|.|
  Fly  1124 LWEIATLGSTPYSQ--LTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPS 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470	11/41 (27%)
		TyrKc	493..746	CDD:197581	66/344 (19%)
		PTKc	497..750	CDD:270623	66/342 (19%)
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	68/348 (20%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	66/340 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900