DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and KDR

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_002244.1	Gene:	KDR / 3791	HGNCID:	6307	Length:	1356	Species:	Homo sapiens

Alignment Length:	440	Identity:	102/440 - (23%)
Similarity:	176/440 - (40%)	Gaps:	127/440 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   396 EKGQSSVVALAVTCVIFGSCLLLSLIAYFYLRYKTCRGRRLTGGNTHEMTLQTPIIERENNGYL- 459
            ||....::.|..|.||   .:...|:....||    ..:|..||.     |:|        |||
Human   759 EKTNLEIIILVGTAVI---AMFFWLLLVIILR----TVKRANGGE-----LKT--------GYLS 803

  Fly   460 --VEDDPLPHSPENFKQQLQQLVEGYERIPRNAL-------RLNVNDVIGDGRFGEIITGKVSTN 515
              ::.|.||            |.|..||:|.:|.       ||.:...:|.|.||::|.......
Human   804 IVMDPDELP------------LDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGI 856

  Fly   516 DFARDC-TLHVLCLDDLNGTTQAQ---LLRELRQLSQLKRQEHLLDFYGVSASPDWFYLI----- 571
            |....| |:.|..|.:  |.|.::   |:.||:.|..:....::::..|....|....::
Human   857 DKTATCRTVAVKMLKE--GATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFC 919

  Fly   572 -------------------------FEQQR-------MSLKRKL---VESRLMAPS-----PRLT 596
                                     |.|.:       :.|||:|   ..|:..|.|     ..|:
Human   920 KFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLS 984

  Fly   597 SLSEQ----------LVLQ----WIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGP 647
            .:.|:          |.|:    :.:::|..|.:|:|.:.:||.|.:.::.::....:|:..||
Human   985 DVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFG- 1048

  Fly   648 LPYMNIAR---QQPDHNR---------WLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYA 700
                 :||   :.||:.|         |:|||.: ....::.:|||||...:.||..:||.:||.
Human  1049 -----LARDIYKDPDYVRKGDARLPLKWMAPETI-FDRVYTIQSDVWSFGVLLWEIFSLGASPYP 1107

  Fly   701 NAVASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSSCEDV 750
             .|..:::....::...|...|.|...::||.:|:||..|||:|.:..::
Human  1108 -GVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSEL 1156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470
		TyrKc	493..746	CDD:197581	75/327 (23%)
		PTKc	497..750	CDD:270623	74/327 (23%)
KDR	NP_002244.1	Ig	41..109	CDD:299845
		IG_like	231..324	CDD:214653
		Ig1_VEGFR	239..326	CDD:143270
		IG_like	340..417	CDD:214653
		Ig2_VEGFR-2	348..417	CDD:143272
		Ig_2	551..661	CDD:290606
		IG	565..661	CDD:214652
		I-set	667..754	CDD:254352
		IGc2	680..744	CDD:197706
		PTKc_VEGFR2	826..1167	CDD:270681	76/341 (22%)
		Pkinase_Tyr	834..1160	CDD:285015	75/333 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1274..1318
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810