DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wsck and Ack-like

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster

Alignment Length:	321	Identity:	81/321 - (25%)
Similarity:	141/321 - (43%)	Gaps:	51/321 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   485 RIPRN-----ALRLNVNDVIGDGRFGEIITGKVSTNDFARDCTLHVLCLDDLNGTTQAQLLRELR 544
            ::|.|     |..::||..:|.|.||.:..|..|..:......:..||.:.:. :...:.|:|..
  Fly   120 KVPNNKHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQ-SNPMEFLKEAA 183

  Fly   545 QLSQLKRQEHLLDFYGVSASPDWFYLIFEQQRM-SLKRKLVESRLMAPSPRLTSLSEQLVLQWIY 608
            .:..:: .|:::..|||..:.|...|:.|...: ||...|.:|.|     |::.|:...:.::..
  Fly   184 IMHSIE-HENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGL-----RVSFLTIPTLCEFAL 242

  Fly   609 ELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQQPDHN---------RWL 664
            ::.:.|.||...:::||.|.:.::.|.|..|:|:|.||....:.:.:.....|         .|.
  Fly   243 QICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWC 307

  Fly   665 APEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAA--VRPAQPAYVYG 727
            |||.:.:. ..:..||||:.....||..:.|..|:  |..:..|:||||.|.  .|..||.....
  Fly   308 APECINYL-RFTNASDVWAFGVCLWEMFSYGFQPW--AALTGLQILEAIDAPNYQRLEQPDCCPS 369

  Fly   728 DLYQLLLNCWQLEPSERSSCEDVAFGVRQLMTSPRHALSFDRVAGGLDTLPPYLP-QLEAV 787
            :.|.|::.|||.:.::|                ||....:|:       ||...| ||:||
  Fly   370 EYYTLMMKCWQDDAAKR----------------PRFGEIYDQ-------LPDMKPEQLKAV 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470
		TyrKc	493..746	CDD:197581	68/264 (26%)
		PTKc	497..750	CDD:270623	66/264 (25%)
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	71/295 (24%)
		PTKc_Ack_like	137..398	CDD:270636	70/293 (24%)
		SH3	400..454	CDD:214620	5/8 (63%)
		CRIB	486..525	CDD:238077
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010