DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wsck and Ptprt

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	XP_038961451.1	Gene:	Ptprt / 362263	RGDID:	1309653	Length:	1504	Species:	Rattus norvegicus

Alignment Length:	646	Identity:	128/646 - (19%)
Similarity:	213/646 - (32%)	Gaps:	213/646 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PLGAAVPQEAPAYYYVGCYTARTDLLHESVYAKTPQTCIEICEHQGHHYAVLASEKCFCANVL-- 90
            |.|.||.:         |::....:.::.|:.:......|:.:...|:  .|...:.|....|
  Rat   413 PFGYAVTR---------CHSYNLTVQYQYVFNQQQYEAEEVIQTSSHY--TLRGLRPFMTIRLRL 466

  Fly    91 -----EPQEQQDEQLCNTRCLANKAQYCGGVGVHSYYSTILTKQPGPHHLRI------SNKTENS 144
                 |.:.:.:|.:..|     :....|.|.:.|.       |.||...:|      .|:|...
  Rat   467 LLSNPEGRMESEELVVQT-----EEDVPGAVPLESI-------QGGPFEEKIYIQWKPPNETNGV 519

  Fly   145 LTLSWNAYEARKLLLAGGAE--AVLPNQLLDNFLIKAQVLKTYSSLPAFPQPEFMVQSTETQFEL 207
            :||....|:|     .|..:  |.|.:|       :.:|.|.               ..||....
  Rat   520 ITLYEINYKA-----VGSLDPSADLSSQ-------RGKVFKL---------------RNETHHLF 557

  Fly   208 TDLHPATLYNISVRAMCKDAQVGQSECGQASIEATTEVGLPSPVPAQPKI-----LSRTDRTVTI 267
            ..|:|.|.|:.:::|         |.........||.:......|:.|:.     |:.||.|:|:
  Rat   558 VGLYPGTTYSFTIKA---------STAKGFGPPVTTRIATKISAPSMPEYDADSPLNETDTTITV 613

  Fly   268 ELSPIRNDNGPLSKLLVIVEY-----------VDNALSQPFDAQLLGSWQQAQQDGVPYYIAAEL 321
            .|.|.::...|:|...::|:.           :....|.|.      |::.|......:|.||||
  Rat   614 MLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPV------SYRNASNLDSLHYFAAEL 672

  Fly   322 DYDRPED-NRTRRFVVGDGKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTK------------- 372
               :|.: ..|:.|.|||.|.|..:.|.|| .|.....|....:|...|.||
  Rat   673 ---KPSNLPVTQPFTVGDNKTYNGYWNPPL-SPLKSYSIYFQALSKANGETKINCVRLATKAPMG 733

  Fly   373 ----------TMYSRGTHDQHVTSLDDFSYATFEKGQSSVVALAVTCVIFGSCLLLSLI------ 421
                      .:.:.|...|:..:::.      ||...:.|.:|  .||.|..:.:.::
  Rat   734 SAQVTPGTPLCLLTTGASTQNSNTVEP------EKQVDNTVKMA--GVIAGLLMFIIILLGVMLT 790

  Fly   422 ------AYFYLRY----KTCRGRRLT-GGNTHEM----TLQTPIIERENNGYLVEDDPLPHSPEN 471
                  ||.|..|    |..:.::.| .|...||    :...|..:...|          .:.|.
  Rat   791 IKRRRNAYSYSYYLSQRKLAKKQKETQSGAQREMGPVASTDKPTTKLSTN----------RNDEG 845

  Fly   472 FKQQLQQLVEGYERIPRNALRLNVNDVIGDGRFGEII--TGKVSTN----------DFARDCTLH 524
            |....|. |.|:.                ||..||:.  |..:.|:          .:.||....
  Rat   846 FSSSSQD-VNGFT----------------DGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQP 893

  Fly   525 VLCLDDLNGTTQAQLLRELRQLSQLKR------QEHLLDFYGVSASPDWFYLIFEQQRMSL 579
            .:.:.||           |:.::|:||      :|...|.|..:.    |..|.||:..:|
  Rat   894 AIRVADL-----------LQHITQMKRGQGYGFKEEYEDSYKTTN----FGGILEQELQAL 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068	10/79 (13%)
		fn3	130..222	CDD:278470	21/99 (21%)
		TyrKc	493..746	CDD:197581	22/105 (21%)
		PTKc	497..750	CDD:270623	22/101 (22%)
Ptprt	XP_038961451.1	MAM	36..193	CDD:214533
		Ig	200..285	CDD:416386
		fn3	298..364	CDD:394996
		FN3	394..484	CDD:238020	13/81 (16%)
		fn3	506..581	CDD:394996	21/110 (19%)
		R-PTPc-T-1	953..1209	CDD:350478
		R-PTPc-T-2	1294..1499	CDD:350482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I10839
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900