DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and Ptprk

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_001025073.2	Gene:	Ptprk / 360302	RGDID:	619706	Length:	1439	Species:	Rattus norvegicus

Alignment Length:	763	Identity:	166/763 - (21%)
Similarity:	267/763 - (34%)	Gaps:	203/763 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 AVPQEAPAYYYVGCYTARTDLLHESVYAKTPQTCIEICEH--QGHHYAVLASEKCFC-------- 86
            ||..|:..|....|:|..                :.||.|  :||:     ..:..|
  Rat   406 AVDWESLGYNITRCHTFN----------------VTICYHYFRGHN-----ESRADCLDMDPKAP 449

  Fly    87 ---ANVLEPQEQQDEQLCNTRCLANKAQYCGGVGVHSYYSTILTKQ--PGPHHLRISNKT--ENS 144
               .|.|.|......::..|.....|         .|..:.|.|.:  |||..::....|  ||.
  Rat   450 QHVVNHLPPYTNVSLKMILTNPEGRK---------ESEETIIQTDEDVPGPVPVKSLQGTSFENK 505

  Fly   145 LTLSWNAYEARKLLLAGGAEAVLPNQLLDNFLIKAQVLKTYSSL----PAFP--QPEFMVQS--T 201
            :.|:|.             |.:.||.::..:.:      :|||:    ||.|  .|...|.:  .
  Rat   506 IFLNWK-------------EPLEPNGIITQYEV------SYSSIRSFDPAVPVAGPPQTVSNLWN 551

  Fly   202 ETQFELTDLHPATLYNISVRAMCKDAQVGQSECGQA-SIEATTEVGLPSPVPAQPKI---LSRTD 262
            .|......|||.|.|...:||.....      .|.| :|..||.:..|| :|....:   |:.|.
  Rat   552 STHHVFMHLHPGTTYQFFIRASTVKG------FGPATAINVTTNISAPS-LPDYEGVDASLNETA 609

  Fly   263 RTVTIELSPIRNDNGPLSKLLVIVEYV-------DNALSQPFDAQLLGSWQQAQQDGVPYYIAAE 320
            .|:|:.|.|.:....|:|...::||.:       :....:.:...:  ::|.:...|.|||.|||
  Rat   610 TTITVLLRPAQAKGAPISAYQIVVEQLHPHRTKREAGTMECYRVPV--TYQNSLSGGAPYYFAAE 672

  Fly   321 LDYDRPEDN--RTRRFVVGDGKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTKTMYSR------ 377
            |    |..|  ....|.|||.:.|..|.|.|| .|....:|....:|::|..|||...|
  Rat   673 L----PPGNLPEPAPFTVGDNRTYKGFWNPPL-APRKGYNIYFQAMSSVEKETKTQCVRIATKAA 732

  Fly   378 GTHDQHVTSLDDFSYATFEKGQSSVVALA-VTCVIFGSCLLLSLIAYFYLRYKTCRGRRLTGGNT 441
            .|.:..|  :.|.:     |....||.:| ::..:....|||.::.....:.|..:.|:...|||
  Rat   733 ATEEPEV--IPDPA-----KQTDRVVKIAGISAGVLVFILLLLVVIVIVKKSKLAKKRKDAMGNT 790

  Fly   442 -HEMTLQTPIIERE--NNGYLVEDDPLP---HSPENFKQQLQQLVEGYERIPRNALRLNVNDVIG 500
             .|||.....::|.  :...|..:|||.   ....||..:    .|.:.....::..|:|...:.
  Rat   791 RQEMTHMVNAMDRSYADQSTLHAEDPLSLTFMDQHNFSPR----YENHSATAESSRLLDVPRYLC 851

  Fly   501 DGRFGEIITGKVSTNDFARDCTLHVLCLDDLNGTTQAQLLRELRQLSQLKRQEHLLDFYGVSASP 565
            :|......||::.......|...|:    :|..|:.:...:|          |:...|.|.|||
  Rat   852 EGTESPYQTGQLHPAIRVADLLQHI----NLMKTSDSYGFKE----------EYESFFEGQSAS- 901

  Fly   566 DWFYLIFEQQRMSLKRKLVESRLMAPSPRLTSLSEQLVLQWIYELASAMNYLSSCQVVHRQLCSH 630
             |.....:|.|    .|.....::|..      ..:::||.:.:..|: :|:::..:...|..||
  Rat   902 -WDVAKKDQNR----AKNRYGNIIAYD------HSRVILQPVEDDPSS-DYINANYIDGYQRPSH 954

  Fly   631 SVFVTSDFKLKLSVFGPLPYMNIARQQPDHNRWLAPEVLRHQHHHSTRSDVWSLACVAWECCALG 695
            .:          :..||:                          |.|..|.|.:.......|.:.
  Rat   955 YI----------ATQGPV--------------------------HETVYDFWRMVWQEQSACIVM 983

  Fly   696 GTPYANAVASNQQLLEAIRAAVRPAQP--AYVYGDLYQLLLNCWQLEP 741
            .|          .|:|..|.......|  ..||||   ..:.|.::||
  Rat   984 VT----------NLVEVGRVKCYKYWPDDTEVYGD---FKVTCVEMEP 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068	13/85 (15%)
		fn3	130..222	CDD:278470	25/101 (25%)
		TyrKc	493..746	CDD:197581	47/251 (19%)
		PTKc	497..750	CDD:270623	45/247 (18%)
Ptprk	NP_001025073.2	MAM	31..191	CDD:214533
		MAM	35..191	CDD:99706
		IG_like	201..287	CDD:214653
		Ig	203..283	CDD:299845
		fn3	293..371	CDD:278470
		FN3	487..588	CDD:238020	30/125 (24%)
		PTPc	886..1140	CDD:214550	38/205 (19%)
		PTPc	913..1140	CDD:238006	28/162 (17%)
		Y_phosphatase	1200..1434	CDD:278528
		PTPc	1202..1434	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I10839
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900