DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wsck and ptprub

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	XP_009290693.1	Gene:	ptprub / 335096	ZFINID:	ZDB-GENE-030131-7036	Length:	1450	Species:	Danio rerio

Alignment Length:	465	Identity:	110/465 - (23%)
Similarity:	170/465 - (36%)	Gaps:	102/465 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 EAPAYYYVGCYTARTDLLHESVYA-------KTPQTCIEICEHQGHHYAV-------LASEKCFC 86
            |.||:....|:|....|.:....|       .|.:.|:.: ||....:.:       ....:...
Zfish   401 EVPAFNLTRCHTYSVSLCYRYTTAGGGGGHNTTVRECLAV-EHNTSRFTLRDLPPFHTIQIRLAL 464

  Fly    87 ANVLEPQEQQDEQLCNTRCLANKAQYCGGVGVHSYYSTILTKQPGPHHLRISNKTENSLTLSWNA 151
            ||. |.:::..|.:..|     :....||:...|     ||..|          .|:.:.|.|.
Zfish   465 ANT-EGKKEGKEVMFQT-----EEDIPGGIAPES-----LTFTP----------LEDMIFLKWE- 507

  Fly   152 YEARKLLLAGGAEAVLPNQLLDNFLIKAQVLKTYSSLPAF--PQPEFMVQ--STETQFELTDLHP 212
                        |.|.||.|:..:.|..|.::  ||.|..  |.|...|.  ..||....::|||
Zfish   508 ------------EPVEPNGLITQYEISYQSIE--SSDPGINVPGPRRTVSKLKNETYHMFSNLHP 558

  Fly   213 ATLYNISVRAMCKDAQVGQSECGQASIEATTEVGLPS-PVPAQPKILSRTDRTVTIELSPIRNDN 276
            .|.|.|||||..... .||:    |..|.||.:..|: .....|..||.|:.|:|:.|.|.:...
Zfish   559 GTTYLISVRARTAKG-FGQT----ALTEITTNISAPTFDYGDMPSPLSETESTITVLLRPAQGRG 618

  Fly   277 GPLSKLLVIVE-----YVDNALSQPFDAQLLGSWQQAQQDGVPYYIAAELDYDRPED-NRTRRFV 335
            .|:|...|:||     .|...|.......:..|..:||..|.|:|..|||.   |.. :....|.
Zfish   619 APVSTYQVVVEEEAGRKVKRELGIQDCFPIPTSHGEAQARGAPHYYTAELP---PSSLSEATPFT 680

  Fly   336 VGDGKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTK----TMYSRGTHDQHVTSLDDFSYATFE 396
            |||...|..:.|.||| |..:..:....:|...|.|:    .:..:.....|..:|:    .|..
Zfish   681 VGDNHTYNGYWNSPLD-PRKNYLVYFQAMSNFRGETRINCIRIARKAACKDHQRALE----VTQR 740

  Fly   397 KGQSSVV------ALAVTCVIFGSCLLL-----SLIAYFYLRYKTCRGRRLTGGNTHEMTLQTPI 450
            ..:..::      .|.|..::.|:.:::     ...:|.|...|.        ||.:    :|||
Zfish   741 SEEMGLILGVCAGGLVVLILLLGAIIIIIKKGRDYYSYSYYPRKP--------GNMN----KTPI 793

  Fly   451 IERENNGYLV 460
            ..|:....::
Zfish   794 TYRQEKSNMM 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068	13/86 (15%)
		fn3	130..222	CDD:278470	27/95 (28%)
		TyrKc	493..746	CDD:197581
		PTKc	497..750	CDD:270623
ptprub	XP_009290693.1	MAM	26..184	CDD:279023
		MAM	26..182	CDD:99706
		IG_like	192..278	CDD:214653
		FN3	282..353	CDD:214495
		FN3	384..480	CDD:238020	15/80 (19%)
		FN3	489..584	CDD:238020	36/129 (28%)
		Y_phosphatase	912..1147	CDD:278528
		PTPc	923..1147	CDD:238006
		PTPc	1179..1442	CDD:214550
		PTPc	1209..1442	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000