DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and tie1

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	XP_001334673.5	Gene:	tie1 / 30746	ZFINID:	ZDB-GENE-990415-55	Length:	1122	Species:	Danio rerio

Alignment Length:	925	Identity:	203/925 - (21%)
Similarity:	331/925 - (35%)	Gaps:	271/925 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PAYYYVGCYTARTDLLHESVYAKTPQTCIEICEH----QGHHYAVLASEKCFCAN---------- 88
            |.:..:.|.||    ..|.::.:   .|.|.|:.    ||..:.:.....|.||:
Zfish   236 PGFMGMRCETA----CREGMFGR---NCQESCKPENGCQGLSFCLTDPYGCSCASGWHGDRCRKP 293

  Fly    89 VLEPQEQQDEQL-CNTR----------CLAN---KAQYC-----------------GGVGVHSYY 122
            .||.....|..| ||.:          |..:   :.|||                 |.:......
Zfish   294 CLEGMYGADCLLSCNCKNKGKCNRFSGCQCSTGWRGQYCEKSDRAPEILDIASNLEGNLNSSHKI 358

  Fly   123 STILTKQPGPHHLRI--------------------------------------------SNKTEN 143
            :...|..|.|.||.|                                            :|..::
Zfish   359 TCSATGHPLPSHLSIELRKLESTVLKAFHTILDSKKSTAHFEIPRLSPEHNGLWECRVSTNGGQD 423

  Fly   144 SLTLSWNAYE------ARKLLLAGGAEAVLPNQLLDNFLIKAQVLKT---YSSLPAFPQPEFMVQ 199
            ||..:....|      |.||||....:.|:  :.:|::.....::.|   |..:........::.
Zfish   424 SLKFTLTVKEPPYPTAAPKLLLRSSRQLVV--KAVDSYAGDGPIVSTKLLYKQVNTEDSWSPIIV 486

  Fly   200 STETQFELTDLHPATLYNISVRAMCKDAQVGQSECGQASIEATTEVGLPSPVPAQPKILSRT--D 262
            ....|..|.:|.|:|.|::.|:.    |:.|:...|....||..|...|.|. |:|:|.|.:  .
Zfish   487 HGSDQITLQNLKPSTKYHVRVQL----ARPGEGGEGPLGPEAIMETDCPEPT-ARPEIDSSSLEG 546

  Fly   263 RTVTIELSPI---RNDNGPLSKL---------------------LVIVEYVDN------------ 291
            |.||:..|.|   |..:|.|.:|                     |..:||..|
Zfish   547 RNVTLRWSLIGRFREASGFLVQLYGPYGEKLWEETTFLNVLSVKLYNLEYHKNYQAVVRLVNCGS 611

  Fly   292 --ALSQPFDAQLL----GSWQQAQQDGVPYYIAAELDYDRPEDNRTRRFVVGDGKRYGRFTNKPL 350
              ..|:|....:.    .|.:..|.|.:. ..|..|.:..|||..      |...:|. ...:|:
Zfish   612 HGPPSRPHHIHIYKQGPSSPRNVQADALS-ISAVRLRWQPPEDPN------GGIVKYS-IEYQPV 668

  Fly   351 DQPDAHVHISLGLVSTLEGVTKTMYSRGTHDQHVTSLD-----DFSYATFEK------------- 397
            .|...|     ..|.|..|      ::.|.|  ||||:     .|....|.|
Zfish   669 GQSSLH-----PWVDTDNG------NKTTKD--VTSLNGSTLYQFRVRAFSKVPGEWSSFVQAQT 720

  Fly   398 ---GQSSVV----------------------ALAVTCVIFGSCLLLSLIAYFYLRYKTCRGRR-- 435
               |.||.:                      ::|||||    .:||:|:|.||:|....:.||
Zfish   721 PGEGLSSFIPTTQQVGRPLAEDHQLLFAVVGSVAVTCV----TILLALLALFYIRKSVLKRRRTF 781

  Fly   436 -LTGGNTHEMTLQTPIIERENNGYLVEDDPLPHSPENFKQQLQQLVEGYERIPRNALRLNVNDVI 499
             ...|:..|..||.      |:|.|.    |...|:...:.|...:..:|.|       ...|||
Zfish   782 TYQSGSGEETILQF------NSGTLT----LTRRPKPSPEPLTYPILEWEDI-------KFEDVI 829

  Fly   500 GDGRFGEIITGKVSTNDFARDCTLHVLCLDDLNGTTQAQLLRELRQLSQLKRQEHLLDFYGVSAS 564
            |:|.||::|...|..:.......:.:| .:..:.........||..|.:|.:..::::..|...:
Zfish   830 GEGNFGQVIKAMVKKDGIKMSAAIKML-KEFASENDHRDFAGELEVLCKLGQHTNIINLIGACEN 893

  Fly   565 PDWFYLIFEQQRM-SLKRKLVESRLMAPSPRL-------TSLSEQLVLQWIYELASAMNYLSSCQ 621
            ..:.|:..|.... :|...|.:||::...|..       ::|:.|.:||:..::|:.|:|||..|
Zfish   894 RGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAKEHGTASTLTSQQLLQFAADVATGMHYLSDKQ 958

  Fly   622 VVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQQPDH---------NRWLAPEVLRHQHHHST 677
            .:||.|.:.:|.|..:...|::.||      ::|.:..:         .||:|.|.|.:. .::|
Zfish   959 FIHRDLAARNVLVGDNLVAKIADFG------LSRGEEVYVKKTMGRLPVRWMAIESLNYS-VYTT 1016

  Fly   678 RSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPS 742
            :|||||...:.||..:||||||.....:  :|.|.:....|..||.....::|:|:..||:..|.
Zfish  1017 KSDVWSFGVLLWEIVSLGGTPYCGMTCA--ELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPY 1079

  Fly   743 ERSSCEDVAFGVRQL 757
            ||.....::..:.::
Zfish  1080 ERPPFSQISVQLNRM 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068	22/117 (19%)
		fn3	130..222	CDD:278470	25/144 (17%)
		TyrKc	493..746	CDD:197581	72/269 (27%)
		PTKc	497..750	CDD:270623	72/269 (27%)
tie1	XP_001334673.5	EGF_CA	<219..244	CDD:238011	1/7 (14%)
		IG_like	346..431	CDD:214653	10/84 (12%)
		fn3	<461..508	CDD:278470	8/46 (17%)
		fn3	538..616	CDD:278470	15/77 (19%)
		FN3	628..720	CDD:238020	25/112 (22%)
		PKc_like	820..1116	CDD:304357	74/292 (25%)
		Pkinase_Tyr	823..1091	CDD:285015	73/284 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900