DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and Csf1r

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_001025072.1	Gene:	Csf1r / 307403	RGDID:	2425	Length:	1022	Species:	Rattus norvegicus

Alignment Length:	761	Identity:	152/761 - (19%)
Similarity:	261/761 - (34%)	Gaps:	260/761 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 YSTILTKQPGPHHLRISNKTENSLTLSWNAYEARKLLLAGGAEAVLPNQLLDNFLIKAQVLKTYS 186
            ||.:.....|          .|:.|:::...|:..|.|. ..:::|....:...|....:...|.
  Rat   320 YSCVANNAAG----------SNTATMNFQVVESAYLNLT-SEQSLLQEVSVGENLDLTVIADAYP 373

  Fly   187 SL---------PAFPQP---EFMVQSTETQFELTDLHPATLYNISVRAMCKDAQVGQSECG---- 235
            .|         |.|..|   ||..|.|...:.. .||   |..:......:.:.:.|::.|
  Rat   374 GLQRYNWTYLGPFFEDPHNLEFRTQWTTYSYSF-KLH---LNRVKPLEAGRYSLMAQNKAGWNNL 434

  Fly   236 --QASIEATTEV------------------GLPSPVPAQPKILSRTDRTVTIELSPIRNDNGPLS 280
              :.::....||                  |.|.|.....:....|||....:.|.:.:|..|
  Rat   435 TFELTLRYPPEVSVTWIPVNGSDVLLCDVSGYPQPNVTWMECRGHTDRCDEAQASQVWDDTQP-- 497

  Fly   281 KLLVIVEYVDNALSQ-PFDAQLLGSWQQAQQDGVPY--------YIAAELDYDRPEDNRTRRFVV 336
                      ..||| ||...:|       |..:|.        |:.      |..:|      |
  Rat   498 ----------EVLSQKPFHRVIL-------QSQLPIGTLKHNMTYVC------RAHNN------V 533

  Fly   337 GDGKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTKTMYSRGTHDQHVTSLDDFSYATFEKGQSS 401
            |:..::.|             .||||            .|:...|:::
  Rat   534 GNSSQFFR-------------AISLG------------QSKQLPDEYL----------------- 556

  Fly   402 VVALAVTCVIFGSCLLLSLIAYFYLRYKTCRGRRLTGGNTHEMTLQTPIIER-ENNGY-LVEDDP 464
            ...:.|.|:...|.|:|.|:...| :||          ...:..::..|||. |.|.| .::...
  Rat   557 FTPVVVACISVMSLLVLLLLLLLY-KYK----------QKPKYQVRWKIIESYEGNNYTFIDPTQ 610

  Fly   465 LPHSPENFKQQLQQLVEGYERIPRNALRLNVNDVIGDGRFGEII------TGKVSTNDFARDCTL 523
            ||::            |.:| .|||  .|.....:|.|.||:::      .||       .|..|
  Rat   611 LPYN------------EKWE-FPRN--NLQFGKTLGAGAFGKVVEATAFGLGK-------EDAVL 653

  Fly   524 HVLCLDDLNGTTQAQ----LLRELRQLSQLKRQEHLLDFYGV----------------------- 561
            .| .:..|..|..|.    |:.||:.:|.|.:.|::::..|.
  Rat   654 KV-AVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFL 717

  Fly   562 ----------SASP------DWFYLIFEQQRMSLKR----------KLVESRLMAPSPRLTSLSE 600
                      |.||      |..|.....::..::|          ..||.|.::.|...:...:
  Rat   718 RRKAEAMLGPSLSPGQDPEGDSSYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFFKQ 782

  Fly   601 QL------------VLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNI 653
            .|            :|.:..::|..|.:|:|...:||.:.:.:|.:||....|:..||      :
  Rat   783 DLDKEASRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFG------L 841

  Fly   654 ARQ-QPDHN-----------RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASN 706
            ||. ..|.|           :|:|||.: ....::.:|||||...:.||..:||..||...:.:|
  Rat   842 ARDIMNDSNYVVKGNARLPVKWMAPESI-FDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNN 905

  Fly   707 QQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSSCEDVAF 752
             :..:.::...:.|||.:...::|.::.:||.|||::|.:.:.:.|
  Rat   906 -KFYKLVKDGYQMAQPVFAPENIYSIMQSCWDLEPTKRPTFQQICF 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470	20/103 (19%)
		TyrKc	493..746	CDD:197581	74/335 (22%)
		PTKc	497..750	CDD:270623	73/335 (22%)
Csf1r	NP_001025072.1	Ig	69..129	CDD:299845
		IG_like	72..145	CDD:214653
		IG_like	157..239	CDD:214653
		Ig	157..223	CDD:299845
		ig	251..337	CDD:278476	5/26 (19%)
		IG_like	253..339	CDD:214653	5/28 (18%)
		Ig	343..442	CDD:299845	18/103 (17%)
		IG_like	355..439	CDD:214653	15/87 (17%)
		Ig	458..541	CDD:143165	22/113 (19%)
		PTKc_CSF-1R	585..957	CDD:133237	88/397 (22%)
		Pkinase_Tyr	624..948	CDD:285015	74/339 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900