DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and fgfr1a

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	XP_009302578.1	Gene:	fgfr1a / 30705	ZFINID:	ZDB-GENE-980526-255	Length:	811	Species:	Danio rerio

Alignment Length:	778	Identity:	165/778 - (21%)
Similarity:	298/778 - (38%)	Gaps:	187/778 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 LRISNKT-ENSLTLSWNAYEARKLL-LAGGAEAVLPNQLLDNFLIKAQVLKTYSSLPA-FPQPEF 196
            |.:|.|. |::..::|    .:.|: |..|....|.|   |...|: :|..|.|.|.| |.|.
Zfish    49 LELSCKAKEDTQKVTW----TKDLVPLVDGEHTRLRN---DQMEIE-KVEPTDSGLYACFAQG-- 103

  Fly   197 MVQSTETQFELTDLHPATLYNISVRAMCKDAQVGQSECGQASIEA--TTEVGLP-SPVPAQP--- 255
             :.|..|::          :||||..       .:.|...:|.||  :.:..|| :||.|||
Zfish   104 -LNSNHTEY----------FNISVTD-------EEDEVDSSSEEAKLSNDQNLPMAPVWAQPDKM 150

  Fly   256 -KILSRTDRTVTIELSPIRNDNGPLSKLLVIVEYVDNALSQPFDAQLLG------SWQQAQQDGV 313
             |.|.....:.|::.....|.| |...|    :::.|......|.::.|      .|....:..|
Zfish   151 EKKLHAVPASKTVKFRCQANGN-PTPTL----KWLKNGKEFKRDQRIGGFKVREHMWTIIMESVV 210

  Fly   314 P--------------------YYI-AAELDYDRP------EDNRTRRFVVGDGKRYGRFTNKPLD 351
            |                    |.: ..|....||      ..|||.  |||...   .|..|...
Zfish   211 PSDRGNYTCLVENRHGSINHTYQLDVVERSPHRPILQAGLPANRTA--VVGSDV---EFECKVFS 270

  Fly   352 QPDAHV----HISL--------GL----------VSTLEGVTKTMYSRGTHDQ----------HV 384
            .|..|:    ||.:        ||          |::.:....|:|: .|.:|          ::
Zfish   271 DPQPHIQWLKHIEVNGSRYGPDGLPYVRALKNSGVNSSDTQVLTLYN-VTEEQSGEYICKVSNYI 334

  Fly   385 TSLDDFSYATFEKGQSSV-----------------VALAVTCVIFGSCLLLSLIAYFYLRYKTCR 432
            ...:..::.|..|...:|                 |...:.||:.|:.:|..:.:   ...|:..
Zfish   335 GQANQSAWLTVVKHLQAVPPTQLPNQTYLEVLIYCVGFFLICVMVGTAVLAKMHS---SAKKSDF 396

  Fly   433 GRRLTGGNTHEMTLQTPIIERENNGYLVEDDPLPHS------PENFKQQLQQLVEG---YERIPR 488
            ..:|.   .|::....|:  |......|:.....||      |.........::.|   || :|:
Zfish   397 NSQLA---VHKLAKSIPL--RRQVTVSVDSSSSMHSGGMLVRPSRLSSSGSPMLSGVSEYE-LPQ 455

  Fly   489 NAL------RLNVNDVIGDGRFGEIITGKVSTNDFARDCTLHVLCL----DDLNGTTQAQLLREL 543
            :..      ||.:...:|:|.||:::..:....|..:...:..:.:    .|......:.|:.|:
Zfish   456 DPRWEVQRDRLVLGKPLGEGCFGQVMMAEAMGMDKEKPNRITKVAVKMLKSDATEKDLSDLISEM 520

  Fly   544 RQLSQLKRQEHLLDFYGVSASPDWFYLIFEQQRMSLKRKLVESRLMAPSPRL-----------TS 597
            ..:..:.:.:::::..|........|:|.|   .:.|..|.|...:...|.:           .:
Zfish   521 EMMKIIGKHKNIINLLGACTQDGPLYVIVE---FAAKGNLREYLRVRRPPGMEYCYNPDQVPVEN 582

  Fly   598 LSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFG---PLPYMNIARQQPD 659
            :|.:.::...|::|..|.||:|.:.:||.|.:.:|.||.|..:|::.||   .:.:::..::..:
Zfish   583 MSIKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 647

  Fly   660 HN---RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQ 721
            ..   :|:|||.| ....::.:|||||...:.||...|||:||.....  ::|.:.::...|..:
Zfish   648 GRLPVKWMAPEAL-FDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPV--EELFKLLKEGHRMDR 709

  Fly   722 PAYVYGDLYQLLLNCWQLEPSERSSCEDVAFGV-RQL-MTSPRHALSFDRVAGGLDTLPPYLP 782
            |:....:||.::.:||...||:|.:.:.:...: |.| |||.:..|.   ::..||...|..|
Zfish   710 PSTCTHELYMMMRDCWHAVPSQRPTFKQLVEDLDRTLSMTSNQEYLD---LSVSLDQFSPNFP 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470	25/89 (28%)
		TyrKc	493..746	CDD:197581	61/273 (22%)
		PTKc	497..750	CDD:270623	60/273 (22%)
fgfr1a	XP_009302578.1	Ig	28..116	CDD:416386	23/87 (26%)
		Ig strand A	28..31	CDD:409353
		Ig strand A'	38..44	CDD:409353
		Ig strand B	47..57	CDD:409353	3/7 (43%)
		Ig strand C	61..66	CDD:409353	1/8 (13%)
		Ig strand C'	69..71	CDD:409353	0/1 (0%)
		Ig strand D	76..80	CDD:409353	0/3 (0%)
		Ig strand E	83..88	CDD:409353	1/5 (20%)
		Ig strand F	94..103	CDD:409353	4/8 (50%)
		Ig strand G	106..116	CDD:409353	4/19 (21%)
		Ig	142..236	CDD:416386	19/98 (19%)
		Ig strand A	142..145	CDD:409353	2/2 (100%)
		Ig strand A'	153..158	CDD:409353	1/4 (25%)
		Ig strand B	162..170	CDD:409353	1/7 (14%)
		Ig strand C	176..181	CDD:409353	1/8 (13%)
		Ig strand C'	184..186	CDD:409353	0/1 (0%)
		Ig strand D	195..198	CDD:409353	0/2 (0%)
		Ig strand E	202..207	CDD:409353	1/4 (25%)
		Ig strand F	216..223	CDD:409353	0/6 (0%)
		Ig strand G	226..236	CDD:409353	1/9 (11%)
		Ig	244..345	CDD:416386	20/106 (19%)
		Ig strand A	244..247	CDD:409353	1/2 (50%)
		Ig strand A'	251..255	CDD:409353	1/3 (33%)
		Ig strand B	263..270	CDD:409353	2/6 (33%)
		Ig strand C	274..281	CDD:409353	1/6 (17%)
		Ig strand D	296..301	CDD:409353	0/4 (0%)
		Ig strand E	311..316	CDD:409353	1/4 (25%)
		Ig strand F	324..332	CDD:409353	0/7 (0%)
		Ig strand G	335..343	CDD:409353	0/7 (0%)
		FGFR3_TM	358..387	CDD:407957	5/28 (18%)
		PTKc_FGFR1	452..753	CDD:270678	69/307 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910