DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and ret

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_858048.2	Gene:	ret / 30512	ZFINID:	ZDB-GENE-980526-307	Length:	1106	Species:	Danio rerio

Alignment Length:	734	Identity:	171/734 - (23%)
Similarity:	278/734 - (37%)	Gaps:	196/734 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 FPQPEFMVQSTETQFELTDLH-PATLYNISVRAMCKDAQVGQSECGQASIEATTEV-GLPSPVPA 253
            ||.||..|.   ..|.:|.|. |....|::............|:.|:..:|...:. |:  .|..
Zfish   366 FPGPEGTVL---LHFNVTVLPVPIRFSNVTYSFTVSQKATTYSQIGKVCVENCQKFKGI--DVTY 425

  Fly   254 QPKILSRTDRTVTIE---------LSPIRNDN-GPL----SKLL-----------VIVEYVDNAL 293
            |.:|:   ||.:|.|         |:...||| |.|    :|:|           ||.:...|.|
Zfish   426 QLEIV---DRNITAEAQSCYWAVSLAQNPNDNTGVLYVNDTKVLRRPECQELEYVVIAQEQQNKL 487

  Fly   294 SQPFDAQLLGSWQQAQQDGV----PYYIAAELDYDRPEDNRTRRFVVGDGK---RYGRFTNKPLD 351
            ..  ..||..|: |.:.|.:    |.:.|......|.:...||......|:   |.||  :|.:.
Zfish   488 QA--KTQLTVSF-QGEADSLKTDEPRFPACAEKRQRGDCEATRGLGAPTGRCQWRQGR--DKGIS 547

  Fly   352 QPDAHVHISLGLVSTLEGVTKTMYSRGTHDQHVTSLDDFSYAT---FEKGQSSVVALAVTCVIF- 412
            :..:....:||  :..:|....:.|:..   .:...|..|.|.   :|:....:.|...||..|
Zfish   548 KRYSTCSPNLG--TCPDGYCDAIESKNI---SICPQDCSSEAIIGGYERDLYGIKAGHGTCYCFE 607

  Fly   413 GSC-----------------------LLLSLI------AYFYLRYKTCRGRRLTGGNTHEMTLQT 448
            |.|                       ::||.|      :||..||             |:.|.:.
Zfish   608 GKCFCERDEPEDDICNDMCKTVIATGIILSFIVSVLLSSYFIHRY-------------HKTTPKP 659

  Fly   449 PI------IERENNGYLVEDDPLPHSPENFKQQLQQLVEGYERI-------------PRNALRLN 494
            ||      ..|....|     |:.:|..|.::.....:|....|             ||..|.|
Zfish   660 PIASAEMTFRRPAQSY-----PISYSANNVRRASLDSMENQVAIDTFKIPEDPKWEFPRKNLVL- 718

  Fly   495 VNDVIGDGRFGEII-------TGKVSTNDFARDCTLHVLCL-DDLNGTTQAQLLRELRQLSQLKR 551
             ...:|:|.||:::       .||      |...|:.|..| ::.:.:....||.|...|.|: .
Zfish   719 -GKTLGEGEFGKVVKATAFRLKGK------AGYTTVAVKMLKENASHSELRDLLSEFTLLKQV-N 775

  Fly   552 QEHLLDFYGVSASPDWFYLIFEQQRM-SLKRKLVESRLMAPS---------------PRLTSLSE 600
            ..|::..||..:.....|||.|..:. ||:..|.|||.:.||               |...:|:.
Zfish   776 HPHVIKMYGACSQDGPLYLIVEYAKYGSLRNFLRESRKVGPSYMGNDANRNSSYLENPDERALTM 840

  Fly   601 QLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQQPDHN---- 661
            ..::.:.::::..|.||:..::|||.|.:.:|.|....|:|:|.||      ::|...:.:
Zfish   841 GDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFG------LSRDVYEEDSYVK 899

  Fly   662 --------RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVR 718
                    :|:|.|.| ..|.::|:|||||...:.||...|||.||..  .:.::|...::...|
Zfish   900 RSKGRIPVKWMAIESL-FDHIYTTQSDVWSFGVLLWEIVTLGGNPYPG--IAPERLFNLLKTGYR 961

  Fly   719 PAQPAYVYGDLYQLLLNCWQLEPSERSSCEDVAFGVRQLM-----------TSPRHALSFDRVAG 772
            ..:|.....::|.|:|.||:.|..:|.:..|::..:.::|           ::|..||.:|....
Zfish   962 MEKPENCTDEMYNLMLRCWKQESDKRPTFSDISKELEKMMVKSRDYLDLAASTPADALLYDDSLS 1026

  Fly   773 GLDT---------LPPYLP 782
            ..||         ||..||
Zfish  1027 EEDTPLVDCSNAPLPRTLP 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470	10/31 (32%)
		TyrKc	493..746	CDD:197581	76/288 (26%)
		PTKc	497..750	CDD:270623	75/288 (26%)
ret	NP_858048.2	CA	186..256	CDD:214520
		PTKc_RET	715..1004	CDD:173631	79/306 (26%)
		Pkinase_Tyr	716..997	CDD:285015	78/298 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810