DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and kita

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	XP_009292910.1	Gene:	kita / 30256	ZFINID:	ZDB-GENE-980526-464	Length:	981	Species:	Danio rerio

Alignment Length:	877	Identity:	165/877 - (18%)
Similarity:	290/877 - (33%)	Gaps:	306/877 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 CLAN-------KAQYCGGVGVHSYYSTILTKQPGPHHLRISNKTENSLTLSWNAYEARKLLLAGG 162
            |||.       ..|.|.|             ||.|:.||.|...|..:::.....|.....:..|
Zfish   136 CLATDPDMKNLNLQKCDG-------------QPLPNSLRYSASLETGVSVEKVRKEFEGCYVCVG 187

  Fly   163 AEAVLPNQLLDNFLIKA-QVLKTYSSLPAFPQPEFMVQSTE---TQFELTDLHPATL-------- 215
            .        ||...:|: :...|...:|..|.|..:.|...   ||.|...|..:|.
Zfish   188 T--------LDAATVKSGRYQLTVRLVPDAPPPITLGQPQRVLLTQGEKLSLSCSTSNVNSDIAV 244

  Fly   216 -------YNISVR---------------AMCKDAQVGQSECGQASIEATTEVGLPS-PV------ 251
                   .|.||.               |:...:.|...:.|..|.||..|.|..: ||
Zfish   245 KWKAPNGVNPSVHQNSHLLTEPITHVRTAILSLSSVTMQDAGNYSCEAINEKGTTAKPVWVNIYE 309

  Fly   252 ----------------------------PAQP------------KILSRTDRTVTIELSPIRNDN 276
                                        .|.|            |:.:.||..:|..    .:.|
Zfish   310 KGFINITSVDNSTRRVRAGESLSLRVVMNAYPKPHTFSWSYSGVKLTNTTDHVITSR----THGN 370

  Fly   277 GPLSKLLVIVEYV-------------DNALSQPFDAQLLGSWQQAQQDGVPYYIAAELDYDRPED 328
            ...|:|.::...|             |..:.|.|:..::..         |..::    |:.|.|
Zfish   371 SYTSELKLVRLKVSESGIYTFSCLNRDATIRQTFEVHVISK---------PQIVS----YEGPID 422

  Fly   329 NRTRRFVVGDG---------------KRYGRFTNKPLDQPDAHVHISL-------GLVSTLEGVT 371
            .:.|  .|.:|               .|.....|...::.|. |.:::       |.|.:...:|
Zfish   423 GQVR--CVAEGYPTPQIKWYYCDLPHSRCSNLLNATQEEEDV-VTVTMTNPPFGKGAVESRLNIT 484

  Fly   372 KTMYSRGTHDQHVTSLDDFSYATFEKGQSSV------------VALAVTCVIFGSCLLLSLIAYF 424
            |..|:  |.:...::..:..|..|...:::|            ||.||..|     |:|.::.|.
Zfish   485 KNNYA--TLECVASANGEIVYTLFSISENTVPHELFTPLLIGFVAAAVILV-----LILIVLTYK 542

  Fly   425 YL---RYKTCRGRRLTGGNTHEMTLQTPIIE--RENNGYLVEDDPLPHSPENFKQQLQQLVEGYE 484
            |:   :|:                :|..:||  ..||...::...||:..:            :|
Zfish   543 YMQKPKYQ----------------IQWKVIEGIHGNNYVYIDPTQLPYDHQ------------WE 579

  Fly   485 RIPRNALRLNVNDVIGDGRFGEIITGK---VSTNDFARDCTLHVLCLDDLNGTTQAQLLRELRQL 546
             .||:.||.  ...:|.|.||:::...   :|..|......:.:| ....:.|.:..|:.||:.|
Zfish   580 -FPRDKLRF--GKTLGSGAFGKVVEATAYGMSKADTVMTVAVKML-KPSAHATEKEALMSELKVL 640

  Fly   547 SQLKRQEHLLD---------------------------------FYGVSASPDWFY--------- 569
            |.|....::::                                 ||..:...|.:|
Zfish   641 SYLGNHINIVNLLGACTVGGPTLVITEYCCFGDLLNFLRRRRVYFYYTTLGEDAYYRNVMMQSEP 705

  Fly   570 ----------------LIFEQQRMSLKRKLVESRLMAPSPRL----TSLSEQLVLQWIYELASAM 614
                            ::..:.|.||.:....|...|.|..|    .:|..:.:|.:.|::|..|
Zfish   706 NDSRNGYMTMKPSVLGILSSENRRSLNKGDSYSDSDAVSEILQEDGLTLDTEDLLSFSYQVAKGM 770

  Fly   615 NYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQ-QPDHN-----------RWLAPE 667
            ::|:|...:||.|.:.::.:|.....|:..||      :||. ..|.|           :|::||
Zfish   771 DFLASKNCIHRDLAARNILLTQGRVAKICDFG------LARDITTDSNYVVKGNARLPVKWMSPE 829

  Fly   668 VLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYVYGDLYQL 732
            .: .:..::..|||||...:.||..:||.:||. .:..:.:..:.|:...|...|.:...::|.:
Zfish   830 SI-FECVYTFESDVWSYGILLWEIFSLGSSPYP-GMPVDSKFYKMIKEGYRMESPEFSPSEMYDI 892

  Fly   733 LLNCWQLEPSERSSCEDVAFGV-RQLMTSPRH 763
            :.:||..:|.:|.|...:...: :|:..|.:|
Zfish   893 MHSCWDADPVKRPSFSKIVEKIEQQISDSTKH 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068	5/16 (31%)
		fn3	130..222	CDD:278470	24/125 (19%)
		TyrKc	493..746	CDD:197581	65/329 (20%)
		PTKc	497..750	CDD:270623	66/329 (20%)
kita	XP_009292910.1	IG_like	123..203	CDD:214653	18/87 (21%)
		IG_like	218..307	CDD:214653	18/88 (20%)
		ig	218..297	CDD:278476	15/78 (19%)
		Ig	311..410	CDD:299845	13/102 (13%)
		IG_like	325..408	CDD:214653	13/86 (15%)
		PTKc_Kit	549..918	CDD:270682	79/408 (19%)
		Pkinase_Tyr	585..914	CDD:285015	68/339 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810