DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and Ptprm

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	XP_038939045.1	Gene:	Ptprm / 29616	RGDID:	620776	Length:	1531	Species:	Rattus norvegicus

Alignment Length:	326	Identity:	83/326 - (25%)
Similarity:	129/326 - (39%)	Gaps:	82/326 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 TYSSLPAF-PQPEFMVQS-------TETQFELTDLHPATLYNISVRAMCKDAQVGQSECGQASIE 240
            ||.::.:| |:.:...||       .||.|....|:|.|.|:.::|     |...:.....|:.:
  Rat   535 TYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIR-----ASTAKGFGPPATNQ 594

  Fly   241 ATTEVGLPSPVPA----QPKILSRTDRTVTIELSPIRNDNGPLSKLLVIVE-----------YVD 290
            .||::..|| :||    .|  |::||.|||:.|.|.::...|:|...::||           .:.
  Rat   595 FTTKISAPS-MPAYEFETP--LNQTDNTVTVLLKPAQSRGAPVSVYQIVVEEERPRRTKKTTEIL 656

  Fly   291 NALSQPF---DAQLLGSWQQAQQDGVPYYIAAELDYDRPEDN--RTRRFVVGDGKRYGRFTNKPL 350
            .....|.   :|.:|.|         .||.|||.    |.|:  ..:.|.:||.|.|..:.|.||
  Rat   657 KCYPVPIHFQNASILNS---------QYYFAAEF----PADSLQAAQPFTIGDNKTYNGYWNTPL 708

  Fly   351 DQPDAHVHISLGLVSTLEGVTK------------------TMYSR---GTHDQHVT-SLDDFSYA 393
             .|.....|.....|...|.||                  |.|.|   ...|..:| ::......
  Rat   709 -LPHKSYRIYYQAASRANGETKIDCVRVATKAAIIVTQLTTPYIRIAPAAGDGQLTGAVTPKPVP 772

  Fly   394 TFEKGQSSVVALAVTCVIFGSCLLLSLIAYFYL-----RYKTCRGRRLTGGNT-HEMTLQTPIIE 452
            ..|||....|.:|  .||.|  :||.:|.:..:     :.|..:.|:.|..:| .|||:....::
  Rat   773 EPEKGTDHTVKIA--GVIAG--ILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMD 833

  Fly   453 R 453
            :
  Rat   834 K 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470	13/45 (29%)
		TyrKc	493..746	CDD:197581
		PTKc	497..750	CDD:270623
Ptprm	XP_038939045.1	FN3	298..377	CDD:214495
		FN3	399..493	CDD:238020
		fn3	515..590	CDD:394996	15/59 (25%)
		R-PTPc-M-1	946..1235	CDD:350481
		R-PTPc-M-2	1321..1526	CDD:350483
		MAM	42..198	CDD:214533
		ig	208..290	CDD:395002
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I10839
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900