DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Wsck and Pdgfra

DIOPT Version :9

Sequence 1:NP_733018.1 Gene:Wsck / 318600 FlyBaseID:FBgn0046685 Length:791 Species:Drosophila melanogaster
Sequence 2:NP_036934.1 Gene:Pdgfra / 25267 RGDID:3284 Length:1088 Species:Rattus norvegicus


Alignment Length:711 Identity:144/711 - (20%)
Similarity:246/711 - (34%) Gaps:262/711 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   205 FELTDLHPATLYNI-----------SVRA-------------MCKDA------------------ 227
            |||:.|.||::..:           :||.             :|||.                  
  Rat   406 FELSTLVPASILELVDDHHGSGGGQTVRCTAEGTPLPNIEWMICKDIKKCNNDTSWTVLASNVSN 470

  Fly   228 ------QVGQS----ECGQASIEATTEVGLPSPVPAQPKILSRTD-----RTVTIELSPIRNDNG 277
                  |.|:|    ....|.:|.|..|          :.|::.|     |.:.:....:|::..
  Rat   471 IITEFHQRGRSTVEGRVSFAKVEETIAV----------RCLAKNDLGIGNRELKLVAPTLRSELT 525

  Fly   278 PLSKLLVIVEYVDNALSQPFDAQLLGSWQQAQQ-------------DGVPY-YI-AAELDYDR-- 325
            ..:.:||::..|..:|     ..|:..|:|..:             ||..| |: ..:|.||.  
  Rat   526 VAAAVLVLLVIVIVSL-----IVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRW 585

  Fly   326 --PEDNRTRRFVVG--------DGKRYGRFTNKP-------LDQPDAHVHISLGLVSTLEGVTKT 373
              |.|......::|        :|..||...::|       :.:|.|.......|:|.|    |.
  Rat   586 EFPRDGLVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSEL----KI 646

  Fly   374 MYSRGTHDQHVTSLDDFSYATFEKGQSSVVALAVTC-------VIFGSCLLLSLIAYFYLRYKTC 431
            |...|.|                   .::|.|...|       :|...|....|:.|.:....:.
  Rat   647 MTHLGPH-------------------LNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSF 692

  Fly   432 RGRR---------LTGGN-THEMTLQTPIIERENNGYLVEDDPLPHSPENFKQQLQQLVEGYERI 486
            ..|.         :.|.| ..|.|....|:..||||..|:          .||            
  Rat   693 MSRHPEKPKKDLDIFGLNPADESTRSYVILSFENNGDYVD----------MKQ------------ 735

  Fly   487 PRNALRLNVNDVIGDGRFGEIITGKVSTNDFARDCTLHVLCLDDLNGTTQAQLLRELRQLSQLKR 551
                                            .|.|.:|..|:          .:|:.:.|.::|
  Rat   736 --------------------------------ADTTQYVPMLE----------RKEVSKYSDIQR 758

  Fly   552 QEHLLDFYGVSASPDWFYLIFEQQRMSLKRKLVES---RLMA--PSPRLTSLSEQLVLQWIYELA 611
            .                  ::::.....|:.:::|   .|::  .|..||.|.   :|.:.|::|
  Rat   759 S------------------LYDRPASYKKKSMLDSEAKNLLSDDDSEGLTLLD---LLSFTYQVA 802

  Fly   612 SAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQ-QPDHN-----------RWL 664
            ..|.:|:|...|||.|.:.:|.:.....:|:..||      :||. ..|.|           :|:
  Rat   803 RGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFG------LARDIMHDSNYVSKGSTFLPVKWM 861

  Fly   665 APEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYVYGDL 729
            |||.: ..:.::|.|||||...:.||..:||||||...:. :......|::..|.|:|.:...::
  Rat   862 APESI-FDNLYTTLSDVWSYGVLLWEIFSLGGTPYPGMMV-DSTFYNKIKSGYRMAKPDHATSEV 924

  Fly   730 YQLLLNCWQLEPSERSSCEDVAFGVRQLMTSPRHALSFDRVAGGLDTLPPYLPQLEAVATM 790
            |::::.||..||.:|.|...::..|..|:.. ::..|::::  .||.|....|   |||.|
  Rat   925 YEIMVQCWNSEPEKRPSFYHLSEIVENLLPG-QYKKSYEKI--HLDFLKSDHP---AVARM 979

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WsckNP_733018.1 WSC 42..115 CDD:280068
fn3 130..222 CDD:278470 7/27 (26%)
TyrKc 493..746 CDD:197581 60/269 (22%)
PTKc 497..750 CDD:270623 61/269 (23%)
PdgfraNP_036934.1 Ig_3 27..99 CDD:404760
Ig 211..309 CDD:416386
Ig strand A 211..215 CDD:409353
Ig strand A' 222..226 CDD:409353
Ig strand B 228..237 CDD:409353
Ig strand C 242..247 CDD:409353
Ig strand C' 250..252 CDD:409353
Ig strand D 256..264 CDD:409353
Ig strand E 268..276 CDD:409353
Ig strand F 286..292 CDD:409353
Ig strand G 297..303 CDD:409353
Ig4_PDGFR 312..412 CDD:409445 3/5 (60%)
Ig strand B 332..336 CDD:409445
Ig strand C 345..349 CDD:409445
Ig strand E 376..380 CDD:409445
Ig strand F 390..395 CDD:409445
Ig strand G 403..406 CDD:409445 144/711 (20%)
PTKc_PDGFR_alpha 554..955 CDD:173653 106/516 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1017..1088
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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