DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and Fgfr4

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	XP_006253668.1	Gene:	Fgfr4 / 25114	RGDID:	2612	Length:	801	Species:	Rattus norvegicus

Alignment Length:	880	Identity:	194/880 - (22%)
Similarity:	307/880 - (34%)	Gaps:	276/880 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 SVYAKTPQTCIEICEHQGHHYAVLASEKCFCANVLEPQEQ-------QDEQLCNTRCLANKAQYC 113
            |::.:||...:|..|.       :..|.| .|.:.|.|||       |..:||           |
  Rat     9 SIFQETPAFSLEASEE-------MEQEPC-PAPISEQQEQVLTVALGQPVRLC-----------C 54

  Fly   114 GGV--GVHSYYSTILTKQPGPHHLRI---SNKTENSLTLSWNAYEARKLLLAGGAEAVLPN--QL 171
            |..  |.|.|.........|    |:   ..:.|.:..|..:|  .|.|.||.|:..|:.|  .:
  Rat    55 GRTERGRHWYKEGSRLASAG----RVRGWRGRLEIASFLPEDA--GRYLCLARGSMTVVHNLTLI 113

  Fly   172 LDNFL--IKAQVLKTYSS----------LPAFPQPEFMVQSTETQFELTDLHPATLYNISVRAMC 224
            :|:.|  |..:..||.||          .|.:..|:.|.:.         ||.....| :|:..|
  Rat   114 MDDSLPSINNEDPKTLSSSSSGHSYLQQAPYWTHPQRMEKK---------LHAVPAGN-TVKFRC 168

  Fly   225 KDA----------QVGQSECGQASIEATT------EVGLPSPVPAQPKILSRTDRTVTIELS--- 270
            ..|          :.||:..|:..|....      .:.:.|.||:     .|...|..:|.|
  Rat   169 PAAGNPMPTIHWLKNGQAFHGENRIGGIRLRHQHWSLVMESVVPS-----DRGTYTCLVENSLGS 228

  Fly   271 ----------------PIRNDNGPLSKLLVIVEYVDNALSQPFDAQLLGSW--------QQAQQD 311
                            ||.....|.:...|:...|:.......|||....|        .....|
  Rat   229 IRYSYLLDVLERSPHRPILQAGLPANTTAVVGSNVELLCKVYSDAQPHIQWLKHIVINGSSFGAD 293

  Fly   312 GVPYY----------IAAELDYDR---PEDNRTRRFVVGD--GKRY------------------- 342
            |.||.          ...|:.|.|   .||......:.|:  |..|
  Rat   294 GFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEAEEEDLAWT 358

  Fly   343 -----GRFTNKPLDQPDAHVHIS----LGLVSTLEGVTKTMYSRGTHDQHVTSLD---------D 389
                 .|:|       |..:::|    |.|:..|.||.......|.|.:...::.         .
  Rat   359 TATSEARYT-------DIILYVSGSLALVLLLLLAGVYHRQAIHGHHSRQPVTVQKLSRFPLARQ 416

  Fly   390 FSYATFEKGQSSVVALAVTCVIFGSCLLLSLIAYFYLRYKTCRGRRLTGGN----THEMTLQTPI 450
            ||..:...|:||                |||:          ||.||:...    |..::|..|:
  Rat   417 FSLESRSSGKSS----------------LSLV----------RGVRLSSSGPPLLTGLVSLDLPL 455

  Fly   451 IERENNGYLVEDDPLPHSPENFKQQLQQLVEGYERIPRNALRLNVNDVIGDGRFGEIITGKVSTN 515
                        |||...|.:                    ||.:...:|:|.||:::..:....
  Rat   456 ------------DPLWEFPRD--------------------RLVLGKPLGEGCFGQVVRAEALGM 488

  Fly   516 DFAR-DCTLHV---LCLDDLNGTTQAQLLRELRQLSQLKRQEHLLDFYGVSASPDWFYLIFEQQR 576
            |.:| |.|..|   :..|:.:....|.|:.|:..:..:.|.:::::..||.......|:|.|...
  Rat   489 DSSRPDQTSTVAVKMLKDNASDKDLADLISEMEMMKLIGRHKNIINLLGVCTQEGPLYVIVEYAA 553

  Fly   577 MSLKRKLVESRLMAPSPRLT---------SLSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSV 632
            ....|:.:.:| ..|.|.|:         .||...::...|::|..|.||.|.:.:||.|.:.:|
  Rat   554 KGNLREFLRAR-RPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNV 617

  Fly   633 FVTSDFKLKLSVFGPLPYMNIAR--------QQPDHNR----WLAPEVLRHQHHHSTRSDVWSLA 685
            .||.|..:|::.||      :||        ::..:.|    |:|||.| ....::.:|||||..
  Rat   618 LVTEDDVMKIADFG------LARGVHHIDYYKKTSNGRLPVKWMAPEAL-FDRVYTHQSDVWSFG 675

  Fly   686 CVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSSCEDV 750
            .:.||...|||:||.....  ::|...:|...|..:|.....:||.|:..||...||:|.:.:.:
  Rat   676 ILLWEIFTLGGSPYPGIPV--EELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQL 738

  Fly   751 AFGVRQLMTSPRHALSFDRVAGGLD---TLPPYLP 782
            ...:.:::.    |:|.:.    ||   |..||.|
  Rat   739 VEALDKVLL----AVSEEY----LDLRLTFGPYSP 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068	16/65 (25%)
		fn3	130..222	CDD:278470	26/108 (24%)
		TyrKc	493..746	CDD:197581	75/277 (27%)
		PTKc	497..750	CDD:270623	74/277 (27%)
Fgfr4	XP_006253668.1	IG	40..108	CDD:214652	20/84 (24%)
		IGc2	47..104	CDD:197706	18/73 (25%)
		Ig	153..237	CDD:299845	17/98 (17%)
		IG_like	158..237	CDD:214653	15/84 (18%)
		IG_like	252..346	CDD:214653	19/93 (20%)
		Ig3_FGFR-2	260..347	CDD:143266	17/86 (20%)
		PKc_like	453..766	CDD:304357	89/363 (25%)
		Pkinase_Tyr	466..742	CDD:285015	75/285 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810