DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Wsck and Ret

DIOPT Version :9

Sequence 1:NP_733018.1 Gene:Wsck / 318600 FlyBaseID:FBgn0046685 Length:791 Species:Drosophila melanogaster
Sequence 2:NP_036775.2 Gene:Ret / 24716 RGDID:3556 Length:1115 Species:Rattus norvegicus


Alignment Length:966 Identity:196/966 - (20%)
Similarity:345/966 - (35%) Gaps:286/966 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 LVAMCLGLPLGAAVPQEAPAYYYVGCYTARTDLLHE------SVYAK---TPQTCIE-------- 67
            |:.:.|.:.||:...:|... ::.||.......:::      |..|:   ||:|.:.        
  Rat   118 LLTVFLQVFLGSTAQREGEC-HWPGCARVYFSFINDTFPNCSSFKARDLCTPETGVSFRIRENRP 181

  Fly    68 --------------ICEHQGHHYAVLASE----KC--FCANVLE----PQEQQDEQLCNTRCL-- 106
                          :|.:....|.:|..:    :|  .|..|..    .:|.|::.:....|.  
  Rat   182 PGTFYQFRMLPVQFLCPNISVKYKLLEGDGLPFRCDPDCLEVSTRWALDRELQEKYVLEAECAVA 246

  Fly   107 ---ANKAQ------------------YCGGVGVHSYYSTILTKQPGPHHLRISNKTENSLTLSWN 150
               |||.:                  :.||||..|.......|             |.::..:..
  Rat   247 GPGANKEKVAVSFPVTVYDEDDSPPTFSGGVGTASAVVEFKRK-------------EGTVVATLQ 298

  Fly   151 AYEA-------------RKLLLAGGAEAV-------LPNQLL---DNFLIKAQ------VLKTYS 186
            .::|             ...||:|.:.|.       .||:.|   :|..::|.      ||....
  Rat   299 VFDADVVPASGELVRRYTSTLLSGDSWAQQTFRVEHTPNETLVQSNNNSVRATMHNYKLVLNRSL 363

  Fly   187 SLPAFPQPEFMVQSTETQFE-----LTDLH------PATL-----YNISV-RAMCKDAQVGQ--- 231
            |:......:.:|...::.|:     :..||      |.||     |:..| |...:.||:|:   
  Rat   364 SISESRVLQLVVLVNDSDFQGPGSGVLFLHFNVSVLPVTLNLPMAYSFPVNRRARRYAQIGKVCV 428

  Fly   232 SECGQASIEATTEVGLPSPVPAQPK---------ILSRTDRTVTIELSPIRNDNGPL-----SKL 282
            ..|.:.|       |:......||.         :.|..|.:.|:.:    ||...|     ::|
  Rat   429 ENCQEFS-------GVSIQYKLQPSSTNCSALGVVTSTEDTSGTLYV----NDTEALRRPECTEL 482

  Fly   283 LVIVEYVDNALSQPFDAQLL----GSWQQAQQDGVPYYIAAELDYDRPE-------DNRTRR--F 334
            ...|...|....:...|.|:    |:: .|::.|.|...|  ::..|||       .:.|.|  :
  Rat   483 QYTVVATDRQTRRQTQASLVVTVEGTY-IAEEVGCPKSCA--VNKRRPECEECGGLGSPTGRCEW 544

  Fly   335 VVGDGKRYGR--FTNKPLDQ--PDAHV------HISLGLVSTLEGVTKTMYSRGTHDQHVTS--- 386
            ..||||...|  .|..|..:  ||.|.      .|::.....|.|.....:.||.. |.:.:   
  Rat   545 RQGDGKGITRNFSTCSPSTRTCPDGHCDALESRDINICPQDCLRGPIVGGHERGER-QGIKAGYG 608

  Fly   387 ----LDDFSYATFEKGQS------SVVALAVTCVIFGSCLLLSLIAYFYL-RYKTCRGRRLTGGN 440
                ..|......|...|      .:....:|..:..|.::..|::.|.: ||..         :
  Rat   609 ICNCFPDEKKCFCEPEDSQGPLCDELCRTVITAAVLFSFIISVLLSTFCIHRYHK---------H 664

  Fly   441 TH-------EMTL----------------QTPIIERENNGYLVEDDPLPHSPENFKQQLQQLVEG 482
            .|       |||.                :.|.::...|...|:...:|..|:            
  Rat   665 AHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLDSMENQVSVDSFKIPEDPK------------ 717

  Fly   483 YERIPRNALRLNVNDVIGDGRFGEIITGKV-STNDFARDCTLHVLCLDDLNGTTQAQLLRELRQL 546
            :| .||..|.|  ...:|:|.||:::.... .....|...|:.|..|.:  ..:|::|...|.:.
  Rat   718 WE-FPRKNLVL--GKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKE--NASQSELRDLLSEF 777

  Fly   547 SQLKR--QEHLLDFYGVSASPDWFYLIFEQQRM-SLKRKLVESRLMAPS---------------- 592
            :.||:  ..|::..||..:......||.|..:. ||:..|.:||.:.|:                
  Rat   778 NLLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRKIGPAYVSSGGSRNSSSLDHP 842

  Fly   593 -PRLTSLSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQ 656
             .|:.::.:.:...|  :::..|.||:..::|||.|.:.::.|....|:|:|.||      ::|.
  Rat   843 DERVLTMGDLISFAW--QISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFG------LSRD 899

  Fly   657 QPDHN------------RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQL 709
            ..:.:            :|:|.|.| ..|.::|:|||||...:.||...|||.||..  ...::|
  Rat   900 VYEEDSYVKKSKGRIPVKWMAIESL-FDHIYTTQSDVWSFGVLLWEIVTLGGNPYPG--IPPERL 961

  Fly   710 LEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSSCEDVAFGVRQLMTSPRHAL 765
            ...::...|..:|.....::|:|:|.||:.||.:|....|::..:.::|...|..|
  Rat   962 FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRDYL 1017

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WsckNP_733018.1 WSC 42..115 CDD:280068 19/136 (14%)
fn3 130..222 CDD:278470 23/137 (17%)
TyrKc 493..746 CDD:197581 71/285 (25%)
PTKc 497..750 CDD:270623 70/285 (25%)
RetNP_036775.2 Cadherin 173..248 CDD:278457 9/74 (12%)
PTKc_RET 724..1013 CDD:173631 74/303 (24%)
Pkinase_Tyr 725..1006 CDD:285015 73/295 (25%)
Inhibitors binding. /evidence=ECO:0000250 806..808 1/1 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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