Protein Alignment Wsck and FGFR4

DIOPT Version :9

• Sequence 1: NP_733018.1
• Gene: Wsck / 318600
• FlyBaseID: FBgn0046685
• Length: 791
• Species: Drosophila melanogaster
• Sequence 2: NP_001341913.1
• Gene: FGFR4 / 2264
• HGNCID: 3691
• Length: 802
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 141/615 - (22%)
• Similarity: 232/615 - (37%)
• Gaps: 168/615 - (27%)

  Fly   236 QASIEATTEVGLPSPVPAQPKILSRTD------RTVTIELSPIRNDNGPLSKLL---------VI 285
            ||.:.|.|...:.|.|....|:.|...      :.:.|..|....|..|..::|         |.
Human   252 QAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVE 316

  Fly   286 VEYVDNALSQPFDAQ----LLG-----SWQQA------QQDGVPYYIAAELDYDRPEDNRTRRFV 335
            |.|:.|..::  ||.    |.|     |:|.|      ::|  |.:.||     .||...|...:
Human   317 VLYLRNVSAE--DAGEYTCLAGNSIGLSYQSAWLTVLPEED--PTWTAA-----APEARYTDIIL 372

  Fly   336 VGDGKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTKTMYSRGTHDQ---HVTSLDDFSYA---T 394
            ...|.                  ::|.::..|.|:.:.....|.|.:   .|..|..|..|   :
Human   373 YASGS------------------LALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFS 419

  Fly   395 FEKG----QSSVVALAVTCVIFGSCLLLSLIAYFYLRYKTCRGRRLTGGNTHEMTLQTPIIEREN 455
            .|.|    .||.:...|.....|..||..|:                       :|..|:
Human   420 LESGSSGKSSSSLVRGVRLSSSGPALLAGLV-----------------------SLDLPL----- 456

  Fly   456 NGYLVEDDPLPHSPENFKQQLQQLVEGYERIPRNALRLNVNDVIGDGRFGEIITGKVSTNDFARD 520
                   |||...|.:                    ||.:...:|:|.||:::..:....|.||.
Human   457 -------DPLWEFPRD--------------------RLVLGKPLGEGCFGQVVRAEAFGMDPARP 494

  Fly   521 ---CTLHVLCL-DDLNGTTQAQLLRELRQLSQLKRQEHLLDFYGVSASPDWFYLIFEQQRMSLKR 581
               .|:.|..| |:.:....|.|:.|:..:..:.|.:::::..||.......|:|.|.......|
Human   495 DQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLR 559

  Fly   582 KLVESRLMAPSPRLT---------SLSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSD 637
            :.:.:| ..|.|.|:         .||..:::...|::|..|.||.|.:.:||.|.:.:|.||.|
Human   560 EFLRAR-RPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTED 623

  Fly   638 FKLKLSVFGPLPYMNIAR--------QQPDHNR----WLAPEVLRHQHHHSTRSDVWSLACVAWE 690
            ..:|::.||      :||        ::..:.|    |:|||.| ....::.:|||||...:.||
Human   624 NVMKIADFG------LARGVHHIDYYKKTSNGRLPVKWMAPEAL-FDRVYTHQSDVWSFGILLWE 681

  Fly   691 CCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSSCEDVAFGVR 755
            ...|||:||.....  ::|...:|...|..:|.:...:||.|:..||...||:|.:.:.:...:.
Human   682 IFTLGGSPYPGIPV--EELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 744

  Fly   756 QLMTSPRHALSFDRVAGGLD---TLPPYLP 782
            :::.    |:|.:.    ||   |..||.|
Human   745 KVLL----AVSEEY----LDLRLTFGPYSP 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470
		TyrKc	493..746	CDD:197581	76/277 (27%)
		PTKc	497..750	CDD:270623	75/277 (27%)
FGFR4	NP_001341913.1	IGc2	50..107	CDD:197706
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	119..148
		Ig	157..241	CDD:325142
		Ig3_FGFR-2	264..351	CDD:143266	20/88 (23%)
		PKc_like	454..767	CDD:328722	90/363 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810