DRSC/TRiP Functional Genomics Resources

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Protein Alignment Wsck and FGFR3

DIOPT Version :9

Sequence 1:NP_733018.1 Gene:Wsck / 318600 FlyBaseID:FBgn0046685 Length:791 Species:Drosophila melanogaster
Sequence 2:XP_006713931.1 Gene:FGFR3 / 2261 HGNCID:3690 Length:811 Species:Homo sapiens


Alignment Length:627 Identity:132/627 - (21%)
Similarity:236/627 - (37%) Gaps:168/627 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   263 RTVTIEL------SPIRNDNGPLSKLLVIVEYVDNALSQPFDAQLLGSW--------QQAQQDGV 313
            :|.|:::      .||.....|.::..|:...|:.......|||....|        .:...||.
Human   239 QTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT 303

  Fly   314 PY------YIAAELDYDRPEDNRTRRFVVG--DGKRY-GRFTNKPLDQPDAHVHISLGLVSTLEG 369
            ||      :|:..::    .|.|.|...|.  ||..| .|.||                   ..|
Human   304 PYVTVLKSWISESVE----ADVRLRLANVSERDGGEYLCRATN-------------------FIG 345

  Fly   370 VTKTMYSRGTH-----DQHVTSLDDFSYATFEKGQ--SSVVALAVTCVIFGSCLLLSLIAYFYLR 427
            |.:..:....|     ::.:...|       |.|.  :.:::..|...:|  .|:::.:....||
Human   346 VAEKAFWLSVHGPRAAEEELVEAD-------EAGSVYAGILSYGVGFFLF--ILVVAAVTLCRLR 401

  Fly   428 YKTCRG---------------RRLTGG--NTHEMTLQTPI--IERENNG-----YLVEDDPLPHS 468
            ....:|               |::|..  :...|:..||:  |.|.::|     ..|.:..||..
Human   402 SPPKKGLGSPTVHKISRFPLKRQVTVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPAD 466

  Fly   469 PENFKQQLQQLVEGYERIPRNALRLNVNDVIGDGRFGEIITGK---VSTNDFARDCTLHVLCL-D 529
            |   |.:|.:            .||.:...:|:|.||:::..:   :..:..|:..|:.|..| |
Human   467 P---KWELSR------------ARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKD 516

  Fly   530 DLNGTTQAQLLRELRQLSQLKRQEHLLDFYGVSASPDWFYLIFEQQRMSLKRKLVESR------- 587
            |......:.|:.|:..:..:.:.:::::..|........|::.|.......|:.:.:|       
Human   517 DATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDY 581

  Fly   588 ----LMAPSPRLTSLSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPL 648
                ...|..:||...   ::...|::|..|.||:|.:.:||.|.:.:|.||.|..:|::.||  
Human   582 SFDTCKPPEEQLTFKD---LVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFG-- 641

  Fly   649 PYMNIARQQPDHN--------------RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPY 699
                :||..  ||              :|:|||.| ....::.:|||||...:.||...|||:||
Human   642 ----LARDV--HNLDYYKKTTNGRLPVKWMAPEAL-FDRVYTHQSDVWSFGVLLWEIFTLGGSPY 699

  Fly   700 ANAVASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSSCEDVAFGVRQLMT----- 759
            .....  ::|.:.::...|..:||....|||.::..||...||:|.:.:.:...:.:::|     
Human   700 PGIPV--EELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTD 762

  Fly   760 -------------------SPRHALSFDRVAGGLDTLPPYLP 782
                               :|..:.|.|......|.|||..|
Human   763 QEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPP 804

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WsckNP_733018.1 WSC 42..115 CDD:280068
fn3 130..222 CDD:278470
TyrKc 493..746 CDD:197581 70/281 (25%)
PTKc 497..750 CDD:270623 69/281 (25%)
FGFR3XP_006713931.1 IGc2 53..110 CDD:197706
IG 54..125 CDD:214652
Ig2_FGFR 161..245 CDD:143265 2/5 (40%)
IG_like 171..245 CDD:214653 2/5 (40%)
IG_like 260..355 CDD:214653 24/117 (21%)
Ig3_FGFR 268..356 CDD:143175 22/110 (20%)
PKc_like 463..797 CDD:304357 80/362 (22%)
Pkinase_Tyr 476..752 CDD:285015 70/289 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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