Protein Alignment Wsck and FGFR3

DIOPT Version :10

• Sequence 1: NP_733018.1
• Gene: Wsck / 318600
• FlyBaseID: FBgn0046685
• Length: 791
• Species: Drosophila melanogaster
• Sequence 2: XP_006713931.1
• Gene: FGFR3 / 2261
• HGNCID: 3690
• Length: 811
• Species: Homo sapiens
• Alignment Length: 627
• Identity: 132/627 - (21%)
• Similarity: 236/627 - (37%)
• Gaps: 168/627 - (26%)

  Fly   263 RTVTIEL------SPIRNDNGPLSKLLVIVEYVDNALSQPFDAQLLGSW--------QQAQQDGV 313
            :|.|:::      .||.....|.::..|:...|:.......|||....|        .:...||.
Human   239 QTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT 303

  Fly   314 PY------YIAAELDYDRPEDNRTRRFVVG--DGKRY-GRFTNKPLDQPDAHVHISLGLVSTLEG 369
            ||      :|:..::    .|.|.|...|.  ||..| .|.||                   ..|
Human   304 PYVTVLKSWISESVE----ADVRLRLANVSERDGGEYLCRATN-------------------FIG 345

  Fly   370 VTKTMYSRGTH-----DQHVTSLDDFSYATFEKGQ--SSVVALAVTCVIFGSCLLLSLIAYFYLR 427
            |.:..:....|     ::.:...|       |.|.  :.:::..|...:|  .|:::.:....||
Human   346 VAEKAFWLSVHGPRAAEEELVEAD-------EAGSVYAGILSYGVGFFLF--ILVVAAVTLCRLR 401

  Fly   428 YKTCRG---------------RRLTGG--NTHEMTLQTPI--IERENNG-----YLVEDDPLPHS 468
            ....:|               |::|..  :...|:..||:  |.|.::|     ..|.:..||..
Human   402 SPPKKGLGSPTVHKISRFPLKRQVTVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPAD 466

  Fly   469 PENFKQQLQQLVEGYERIPRNALRLNVNDVIGDGRFGEIITGK---VSTNDFARDCTLHVLCL-D 529
            |   |.:|.:            .||.:...:|:|.||:::..:   :..:..|:..|:.|..| |
Human   467 P---KWELSR------------ARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKD 516

  Fly   530 DLNGTTQAQLLRELRQLSQLKRQEHLLDFYGVSASPDWFYLIFEQQRMSLKRKLVESR------- 587
            |......:.|:.|:..:..:.:.:::::..|........|::.|.......|:.:.:|
Human   517 DATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDY 581

  Fly   588 ----LMAPSPRLTSLSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPL 648
                ...|..:||...   ::...|::|..|.||:|.:.:||.|.:.:|.||.|..:|::.||
Human   582 SFDTCKPPEEQLTFKD---LVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFG-- 641

  Fly   649 PYMNIARQQPDHN--------------RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPY 699
                :||..  ||              :|:|||.| ....::.:|||||...:.||...|||:||
Human   642 ----LARDV--HNLDYYKKTTNGRLPVKWMAPEAL-FDRVYTHQSDVWSFGVLLWEIFTLGGSPY 699

  Fly   700 ANAVASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSSCEDVAFGVRQLMT----- 759
            .....  ::|.:.::...|..:||....|||.::..||...||:|.:.:.:...:.:::|
Human   700 PGIPV--EELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTD 762

  Fly   760 -------------------SPRHALSFDRVAGGLDTLPPYLP 782
                               :|..:.|.|......|.|||..|
Human   763 QEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPP 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:460348
		fn3	130..222	CDD:394996
		PTKc	497..750	CDD:270623	69/281 (25%)
FGFR3	XP_006713931.1	Ig	37..109	CDD:472250
		Ig strand B	57..61	CDD:409362
		Ig strand C	69..75	CDD:409362
		Ig strand E	92..96	CDD:409362
		IgI_2_FGFR	151..245	CDD:409443	2/5 (40%)
		Ig strand A	151..154	CDD:409443
		Ig strand A'	162..167	CDD:409443
		Ig strand B	171..179	CDD:409443
		Ig strand C	185..190	CDD:409443
		Ig strand C'	193..195	CDD:409443
		Ig strand D	204..207	CDD:409443
		Ig strand E	211..216	CDD:409443
		Ig strand F	225..232	CDD:409443
		Ig strand G	235..245	CDD:409443	2/5 (40%)
		IgI_3_FGFR	253..354	CDD:409363	26/123 (21%)
		Ig strand A	253..256	CDD:409363	2/2 (100%)
		Ig strand A'	260..264	CDD:409363	1/3 (33%)
		Ig strand B	272..279	CDD:409363	0/6 (0%)
		Ig strand C	283..290	CDD:409363	1/6 (17%)
		Ig strand D	305..310	CDD:409363	1/4 (25%)
		Ig strand E	321..326	CDD:409363	2/4 (50%)
		Ig strand F	334..342	CDD:409363	2/7 (29%)
		Ig strand G	345..353	CDD:409363	2/7 (29%)
		Protein Kinases, catalytic domain	463..797	CDD:473864	80/362 (22%)