DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and FGFR1

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	XP_011542745.1	Gene:	FGFR1 / 2260	HGNCID:	3688	Length:	865	Species:	Homo sapiens

Alignment Length:	790	Identity:	151/790 - (19%)
Similarity:	274/790 - (34%)	Gaps:	229/790 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 STILTKQPGPHHLRISNKTENSLTLSWNA-YEARKLLLAGGAEAVLPNQLLDNFLIKAQVLKTYS 186
            :|:.|.:|.|        |.......|.| .|....|       |.|..||.   ::.::.....
Human    49 ATLCTARPSP--------TLPEQAQPWGAPVEVESFL-------VHPGDLLQ---LRCRLRDDVQ 95

  Fly   187 SLPAFPQPEFMVQSTET-----QFELTDLHPA-----------------TLYNISVRAMCKDAQV 229
            |:........:.:|..|     :.|:.|..||                 |.::::|......::.
Human    96 SINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSED 160

  Fly   230 GQSECGQASIEATTEVGLPSPVPAQP---------KILSRTDRTVTIELS-PIRNDNGPLSKLLV 284
            ...:...:|.|..|:...|:.:|..|         |.|.......|::.. |......|
Human   161 DDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNP------ 219

  Fly   285 IVEYVDNALSQPFDAQLLG------SWQQAQQDGVP-----YYIAAELDYDRPEDNRTRRFVVGD 338
            .:.::.|......|.::.|      :|.......||     |....|.:|.  ..|.|.:..|.:
Human   220 TLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYG--SINHTYQLDVVE 282

  Fly   339 GKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTKTMYSRGTHDQ---HV---------------- 384
                 |..::|:.|.....:.::.|.|.:|.:.|.......|.|   |:
Human   283 -----RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 342

  Fly   385 ---------------------TSLDDFSYATFEKGQS-----------SVVALAVTCVIFGSCLL 417
                                 .|.:|....|...|.|           .:.||.....:..|.|.
Human   343 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLY 407

  Fly   418 LSLIAY----FYLR--------YKTCRGRRLTGGNT----HEMTLQTPIIERE-----------N 455
            |.:|.|    |.:.        ||...|.:.:..::    |::....| :.|:           |
Human   408 LEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIP-LRRQVTVSADSSASMN 471

  Fly   456 NGYL-----------------VEDDPLPHSPENFKQQLQQLVEGYERIPRNALRLNVNDVIGDGR 503
            :|.|                 |.:..||..|.            :| :||:  ||.:...:|:|.
Human   472 SGVLLVRPSRLSSSGTPMLAGVSEYELPEDPR------------WE-LPRD--RLVLGKPLGEGC 521

  Fly   504 FGEIITG--------------KVSTNDFARDCTLHVLCLDDLNGTTQAQLLRELRQLSQLKRQEH 554
            ||:::..              ||:......|.|...|          :.|:.|:..:..:.:.::
Human   522 FGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL----------SDLISEMEMMKMIGKHKN 576

  Fly   555 LLDFYGVSASPDWFYLIFEQQRMSLKRKLVESR-------LMAPS--PRLTSLSEQLVLQWIYEL 610
            :::..|........|:|.|.......|:.:::|       ...||  |. ..||.:.::...|::
Human   577 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPE-EQLSSKDLVSCAYQV 640

  Fly   611 ASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFG---PLPYMNIARQQPDHN---RWLAPEVL 669
            |..|.||:|.:.:||.|.:.:|.||.|..:|::.||   .:.:::..::..:..   :|:|||.|
Human   641 ARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEAL 705

  Fly   670 RHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYVYGDLYQLLL 734
             ....::.:|||||...:.||...|||:||.....  ::|.:.::...|..:|:....:||.::.
Human   706 -FDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPV--EELFKLLKEGHRMDKPSNCTNELYMMMR 767

  Fly   735 NCWQLEPSER 744
            :||...||:|
Human   768 DCWHAVPSQR 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470	20/114 (18%)
		TyrKc	493..746	CDD:197581	66/281 (23%)
		PTKc	497..750	CDD:270623	65/277 (23%)
FGFR1	XP_011542745.1	Ig1_FGFR	73..151	CDD:143174	13/87 (15%)
		IG_like	77..151	CDD:214653	13/83 (16%)
		I-set	193..280	CDD:254352	16/94 (17%)
		Ig2_FGFR	196..280	CDD:143265	16/91 (18%)
		IG_like	295..391	CDD:214653	12/95 (13%)
		Ig3_FGFR	303..392	CDD:143175	11/88 (13%)
		PTKc_FGFR1	497..797	CDD:270678	73/310 (24%)
		Pkinase_Tyr	511..787	CDD:285015	66/281 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810