DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and Tek

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_038718.2	Gene:	Tek / 21687	MGIID:	98664	Length:	1123	Species:	Mus musculus

Alignment Length:	799	Identity:	171/799 - (21%)
Similarity:	308/799 - (38%)	Gaps:	164/799 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 HRPIP----IWLSSCLVAMCLGL---PLGAAV-----PQEAPAYYYVGCYTARTDLLHESVYAKT 61
            :|.:|    :|:  |.|....|:   |...:|     |..||.....|...|..::..|..:...
Mouse   412 NRVLPPDSGVWV--CSVNTVAGMVEKPFNISVKVLPEPLHAPNVIDTGHNFAIINISSEPYFGDG 474

  Fly    62 PQTCIEIC---EHQGHHYAVLASEKCFCANVLEPQEQQDEQLCNTRCLANKAQYCGGVGVH---- 119
            |....::.   .:|...|..:.:| .|..|.|||  :.|.:||..  ||...:  ||.| |
Mouse   475 PIKSKKLFYKPVNQAWKYIEVTNE-IFTLNYLEP--RTDYELCVQ--LARPGE--GGEG-HPGPV 531

  Fly   120 SYYSTILTKQPGPHHLRISNKTENSLTLSWNAYEARKLLLAGGAEAVLPNQLLDNFLIKAQ--VL 182
            ..::|.....|.|..|.:..|::.:|.|:|              :.:..|. .|.|.::.:  .|
Mouse   532 RRFTTASIGLPPPRGLSLLPKSQTALNLTW--------------QPIFTNS-EDEFYVEVERRSL 581

  Fly   183 KTYSSLPAFPQPEFMVQSTETQFELTDLHPATLYNISVRAMCKDAQVGQSECGQASIEATTEVGL 247
            :|.|.     |....|....|...|::|.|...|.:..|...| ||...||    .:.|.|...:
Mouse   582 QTTSD-----QQNIKVPGNLTSVLLSNLVPREQYTVRARVNTK-AQGEWSE----ELRAWTLSDI 636

  Fly   248 PSPVPAQPKILSRTDRTVTIELSPIRNDNGPLSKLLVIVEYVDNALSQPFDAQLLGSW-QQAQQD 311
            ..|.|...||.:.||.|..:..:.:  |...:|.:::..:.......|..|.::..:. .|.|..
Mouse   637 LPPQPENIKISNITDSTAMVSWTIV--DGYSISSIIIRYKVQGKNEDQHIDVKIKNATVTQYQLK 699

  Fly   312 GVPYYIAAELDYDRPEDNRTRRFVVGDGKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTKTMYS 376
            |:                                      :|:...|:.:...:.: |.:...:|
Mouse   700 GL--------------------------------------EPETTYHVDIFAENNI-GSSNPAFS 725

  Fly   377 RGTHDQHVTSLDDFSYATFEKGQSSVVALAV------TCVIFGSCLLLSLIAYFYLRYKTCRGRR 435
                  |.......|.|:.:.|...::.:|:      ||:    .:||:.:....|:....: ||
Mouse   726 ------HELRTLPHSPASADLGGGKMLLIAILGSAGMTCI----TVLLAFLIMLQLKRANVQ-RR 779

  Fly   436 LTGGNTHEMTLQTPIIERENNGYLVEDDPLPHSPENFKQQLQQLVEGYERIPRNALRLNVNDVIG 500
            :  ....:...:.|.:: .|:|.|..:....::|:         ...|..:..|.::.  .||||
Mouse   780 M--AQAFQNVREEPAVQ-FNSGTLALNRKAKNNPD---------PTIYPVLDWNDIKF--QDVIG 830

  Fly   501 DGRFGEIITGKVSTNDFARDCTL----HVLCLDDLNGTTQAQLLRELRQLSQLKRQEHLLDFYGV 561
            :|.||:::..::..:....|..:    .....||     ......||..|.:|....::::..|.
Mouse   831 EGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDD-----HRDFAGELEVLCKLGHHPNIINLLGA 890

  Fly   562 SASPDWFYLIFE-QQRMSLKRKLVESRLMAPSPRL-------TSLSEQLVLQWIYELASAMNYLS 618
            .....:.||..| ....:|...|.:||::...|..       ::||.|.:|.:..::|..|:|||
Mouse   891 CEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLS 955

  Fly   619 SCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQQPDH---------NRWLAPEVLRHQHH 674
            ..|.:||.|.:.::.|..::..|::.||      ::|.|..:         .||:|.|.|.:. .
Mouse   956 QKQFIHRDLAARNILVGENYIAKIADFG------LSRGQEVYVKKTMGRLPVRWMAIESLNYS-V 1013

  Fly   675 HSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQL 739
            ::|.|||||...:.||..:||||||.....:  :|.|.:....|..:|.....::|.|:..||:.
Mouse  1014 YTTNSDVWSYGVLLWEIVSLGGTPYCGMTCA--ELYEKLPQGYRLEKPLNCDDEVYDLMRQCWRE 1076

  Fly   740 EPSERSSCEDVAFGVRQLM 758
            :|.||.|...:...:.:::
Mouse  1077 KPYERPSFAQILVSLNRML 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068	17/75 (23%)
		fn3	130..222	CDD:278470	20/93 (22%)
		TyrKc	493..746	CDD:197581	72/273 (26%)
		PTKc	497..750	CDD:270623	73/273 (27%)
Tek	NP_038718.2	Ig_Tie2_1	24..118	CDD:287411
		EGF_Lam	230..275	CDD:238012
		EGF_2	311..340	CDD:285248
		fn3	445..516	CDD:278470	18/73 (25%)
		fn3	542..625	CDD:278470	24/103 (23%)
		FN3	638..730	CDD:238020	19/138 (14%)
		PTKc_Tie2	815..1117	CDD:133219	75/297 (25%)
		STYKc	823..1091	CDD:214568	73/283 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810