DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wsck and Ptprs

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	XP_006523937.1	Gene:	Ptprs / 19280	MGIID:	97815	Length:	1920	Species:	Mus musculus

Alignment Length:	819	Identity:	153/819 - (18%)
Similarity:	266/819 - (32%)	Gaps:	306/819 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 QPGPHHLRISNKTENSLTLSW----NAYEAR----------------KLLLAGGAEAVLPNQLLD 173
            |||         .|.:|||..    .|||.|                :..||  .:.|.|.....
Mouse   977 QPG---------AETALTLRGLRPETAYELRVRAHTRRGPGPFSPPLRYRLA--RDPVSPKNFKV 1030

  Fly   174 NFLIKAQVL------KTYSSLPAFPQP--------EFMVQSTETQFELTDLHPATLYNISVRAMC 224
            ..::|..||      ..|:|    |.|        ...|....|:..:|.|.|.|.||..:
Mouse  1031 KMIMKTSVLLSWEFPDNYNS----PTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVL---- 1087

  Fly   225 KDAQVGQSECG-QASIEATTEVGLPSPVPAQPKILSRTDR-------------TVTIE-----LS 270
              ...|.|..| |.::.|.|...:.|   .:|.:..:.|.             .||::     :.
Mouse  1088 --TNRGSSLGGLQQTVTARTAFNMLS---GKPSVAPKPDNDGFIVVYLPDGQSPVTVQNYFIVMV 1147

  Fly   271 PIRNDNG---PLSKLLVIVEYVD-NALSQPFDAQLLGSWQQAQQDGVPY-YIAAELDYDRPEDNR 330
            |:|...|   |:  ||...|.:| ..|.|........|.:.::|..||. ||||
Mouse  1148 PLRKSRGGQFPV--LLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAA----------- 1199

  Fly   331 TRRFVV-------GDGKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTKTMYSRGTHDQHVTSLD 388
              ||.:       |:.|:||.|.|:.|:....:|   |.:::.|:....|..:....|..  .||
Mouse  1200 --RFSILPAVFHPGNQKQYGGFDNRGLEPGHRYV---LFVLAVLQKNEPTFAASPFSDPF--QLD 1257

  Fly   389 DFSYATFEKGQSSVVAL--AVTCVIFGSCLLLSLIAYFYLRYKTCRGRRLTGGNTHEMTLQTPII 451
            :........|:..::.:  .|..|:|..|::::::.|   :.|....|:.:...|..:.
Mouse  1258 NPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLY---KNKPDSKRKDSEPRTKCLL------ 1313

  Fly   452 ERENNGYLVEDDPLPHSPE--------NFKQ---------QLQQLVEGYERIPRN-ALRLNVN-D 497
               ||.     |..||.|:        ||:.         .:..:.|..||:..| :|:|:.. :
Mouse  1314 ---NNA-----DLAPHHPKDPVEMRRINFQTPGMLSHPPIPITDMAEHMERLKANDSLKLSQEYE 1370

  Fly   498 VIGDG-----------------RFGEIITGKVSTNDFARDCTLHVLCLDDLNGTTQAQLLRE--- 542
            .|..|                 |:..:|     ..|.:|      :.|..|.|...:..:..
Mouse  1371 SIDPGQQFTWEHSNLEANKPKNRYANVI-----AYDHSR------VILQPLEGIMGSDYINANYV 1424

  Fly   543 ---LRQLSQLKRQEHLLDFYGVSASPDWFYLIFEQQ--------RMSLKRKL------------- 583
               .||.:.:..|..|.:.:|     |::.:::||:        |:..|.::
Mouse  1425 DGYRRQNAYIATQGPLPETFG-----DFWRMVWEQRSATVVMMTRLEEKSRIKCDQYWPNRGTET 1484

  Fly   584 ---VESRLMAPSP-------------------------RLTSLSEQLVLQWIYELASAMNYLSSC 620
               ::..|:....                         :.|:..:..|.::.....:.:..:.:|
Mouse  1485 YGFIQVTLLDTMELATFCVRTFSLHKNGSSEKREVRHFQFTAWPDHGVPEYPTPFLAFLRRVKTC 1549

  Fly   621 Q-------VVHRQLCSHSV-----FVTSDFKLK-------LSVFGPLPYMNIARQQPDHNRWLAP 666
            .       |||   ||..|     |:..|..|:       :.|:|.:..|
Mouse  1550 NPPDAGPIVVH---CSAGVGRTGCFIVIDAMLERIKTEKTVDVYGHVTLM--------------- 1596

  Fly   667 EVLRHQHHHSTRS-DVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVR--PAQPAYVYGD 728
               |.|.::..:: |.:...                    ::.||||:.....  ||:..|.|
Mouse  1597 ---RSQRNYMVQTEDQYGFI--------------------HEALLEAVGCGNTEVPARSLYTY-- 1636

  Fly   729 LYQLLLNCWQLEPSERSSCEDVAFGVRQLMTSPRHALSF 767
                :....|:||.|..:..::.|  ::|.:|..|...|
Mouse  1637 ----IQKLAQVEPGEHVTGMELEF--KRLASSKAHTSRF 1669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470	29/125 (23%)
		TyrKc	493..746	CDD:197581	51/347 (15%)
		PTKc	497..750	CDD:270623	50/346 (14%)
Ptprs	XP_006523937.1	I-set	33..124	CDD:400151
		Ig strand A	33..36	CDD:409353
		Ig strand A'	42..45	CDD:409353
		Ig strand B	50..57	CDD:409353
		Ig strand C	63..68	CDD:409353
		Ig strand C'	71..73	CDD:409353
		Ig strand D	80..84	CDD:409353
		Ig strand E	86..93	CDD:409353
		Ig strand F	103..111	CDD:409353
		Ig strand G	114..124	CDD:409353
		IgI_2_RPTP_IIa_LAR_like	137..226	CDD:409400
		Ig strand B	152..156	CDD:409400
		Ig strand C	165..169	CDD:409400
		Ig strand E	190..194	CDD:409400
		Ig strand F	204..209	CDD:409400
		Ig strand G	216..219	CDD:409400
		IgI_3_RPTP_IIa_LAR_like	239..320	CDD:409401
		Ig strand B	253..257	CDD:409401
		Ig strand C	266..270	CDD:409401
		Ig strand E	287..291	CDD:409401
		Ig strand F	299..304	CDD:409401
		Ig strand G	312..315	CDD:409401
		FN3	323..412	CDD:238020
		FN3	419..511	CDD:238020
		FN3	516..604	CDD:238020
		FN3	612..706	CDD:238020
		FN3	714..819	CDD:238020
		FN3	929..1017	CDD:238020	11/48 (23%)
		FN3	1022..1105	CDD:238020	22/92 (24%)
		PTP_tm	<1211..1295	CDD:408631	20/91 (22%)
		R-PTPc-S-1	1342..1623	CDD:350473	48/337 (14%)
		R-PTP-S-2	1625..1914	CDD:350475	13/53 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900