DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and Ptprc

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_001104786.2	Gene:	Ptprc / 19264	MGIID:	97810	Length:	1293	Species:	Mus musculus

Alignment Length:	748	Identity:	133/748 - (17%)
Similarity:	259/748 - (34%)	Gaps:	231/748 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 ARTDLLHESVYAKTPQTCIEICEHQGHHYAVLASEKCFCANVLEPQEQQDEQLCNTRC--LANKA 110
            |.||....::...|.|||..:..:...:|...:|.:.|.|::   ::.|:.:..|..|  :.|..
Mouse   186 ASTDPPSTTIATTTKQTCAAMFGNITVNYTYESSNQTFKADL---KDVQNAKCGNEDCENVLNNL 247

  Fly   111 QYCGGVGVHSY-------YSTI-LTKQPGP-----HHLRISNKTENSLTLSWNA--YEARKLLLA 160
            :.|..:...|.       .:|| |...||.     |......|...|:.|.|..  .:.|| ..:
Mouse   248 EECSQIKNISVSNDSCAPATTIDLYVPPGTDKFSLHDCTPKEKANTSICLEWKTKNLDFRK-CNS 311

  Fly   161 GGAEAVLPNQLLDNFLIKAQVLKTYSSLPAFPQPEFMVQSTETQFELTDLHPATLYNISVRAMCK 225
            .....||..:..:|    .:.::..:.:|             .:.:|.:|...|.|......:.:
Mouse   312 DNISYVLHCEPENN----TKCIRRNTFIP-------------ERCQLDNLRAQTNYTCVAEILYR 359

  Fly   226 DAQVGQSECGQASIEATTEVGLP-SPVPAQPKILSRTDRTVTIELSPI---RNDNGPLSKLLVIV 286
            ..::.::     .|...|::|:| :|.|:.....:|  :|:.....|:   .:.:.|...:|...
Mouse   360 GVKLVKN-----VINVQTDLGIPETPKPSCGDPAAR--KTLVSWPEPVSKPESASKPHGYVLCYK 417

  Fly   287 EYVDNALSQP-----FDAQLLGSWQQAQQDGVPYYIAAELDY--------------------DRP 326
            ...:...|.|     |:.:.|..::        ||..:.|.|                    |||
Mouse   418 NNSEKCKSLPNNVTSFEVESLKPYK--------YYEVSLLAYVNGKIQRNGTAEKCNFHTKADRP 474

  Fly   327 EDNRTRRFVVGDGKRYGRFTNKPLDQPDAHVHISLG-------------LVSTLEGVTKTMYSRG 378
            :            |..|..|::|.|.   .::::.|             ||....|...|.|::.
Mouse   475 D------------KVNGMKTSRPTDN---SINVTCGPPYETNGPKTFYILVVRSGGSFVTKYNKT 524

  Fly   379 THDQHVTSL---DDFSY-ATFEKG---QSSVV----------ALAVTCVIFGSCLLLSLIAYFYL 426
            ....:|.:|   .|:.: .:|..|   ..||:          ||.:..|..   ::::.||...:
Mouse   525 NCQFYVDNLYYSTDYEFLVSFHNGVYEGDSVIRNESTNFNAKALIIFLVFL---IIVTSIALLVV 586

  Fly   427 RYKTCRGRRLTGGNTHEMTLQTPIIERENNGYLVEDDPLPHSP---ENFKQQLQQLVEG------ 482
            .||....|:....|..|   |..::||::...|::.:|: ||.   |.:|:::..  ||
Mouse   587 LYKIYDLRKKRSSNLDE---QQELVERDDEKQLMDVEPI-HSDILLETYKRKIAD--EGRLFLAE 645

  Fly   483 YERIPRNALRLNVNDV-----IGDGRFGEIITGKVSTNDFARDCTLHVLCLDDLNGTTQAQLL-- 540
            ::.|||...:..:.|.     ....|:.:|:     ..|:.|      :.|.::||...:..:
Mouse   646 FQSIPRVFSKFPIKDARKPHNQNKNRYVDIL-----PYDYNR------VELSEINGDAGSTYINA 699

  Fly   541 ------RELRQ--LSQLKRQEHLLDFYGVSASPDWFYLIFEQQRMSLKRKLVESRLMAPSPRLTS 597
                  :|.|:  .:|..|.|.:.||:         .:|:||:
Mouse   700 SYIDGFKEPRKYIAAQGPRDETVDDFW---------RMIWEQK---------------------- 733

  Fly   598 LSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQQPDHNR 662
                         |:.:..::.|:..:|..|:.......:        |...:.:|.....||.|
Mouse   734 -------------ATVIVMVTRCEEGNRNKCAEYWPSMEE--------GTRAFKDIVVTINDHKR 777

  Fly   663 WLAPEVL------RHQHHHSTRSDVWSLACVAW 689
              .|:.:      .|:...:|..:|..:...:|
Mouse   778 --CPDYIIQKLNVAHKKEKATGREVTHIQFTSW 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068	16/68 (24%)
		fn3	130..222	CDD:278470	17/98 (17%)
		TyrKc	493..746	CDD:197581	32/218 (15%)
		PTKc	497..750	CDD:270623	32/214 (15%)
Ptprc	NP_001104786.2	PTP_N	7..31	CDD:372119
		Herpes_BLLF1	<27..>191	CDD:282904	3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..174
		CD45	212..265	CDD:372194	10/55 (18%)
		FN3	393..451	CDD:238020	10/65 (15%)
		FN3	474..553	CDD:238020	17/93 (18%)
		R-PTPc-C-1	696..896	CDD:350405	24/167 (14%)
		Substrate binding. /evidence=ECO:0000250	842..848
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	980..1003
		R-PTP-C-2	1006..1211	CDD:350406
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1240..1293
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900