DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wsck and old-2

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_496123.1	Gene:	old-2 / 191738	WormBaseID:	WBGene00003863	Length:	498	Species:	Caenorhabditis elegans

Alignment Length:	452	Identity:	99/452 - (21%)
Similarity:	182/452 - (40%)	Gaps:	119/452 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   396 EKGQSSV------------VALAVTCVIFGSCLLLSLIAYFYLRYKTCRGRRL----TGGNTHEM 444
            |.|.|:|            ||||:     |.|.|:.       .||: :.|:|    :.||.:.:
Worm    45 ELGDSNVQQIIFISLYSVFVALAI-----GICCLIK-------AYKS-KKRQLPANRSKGNEYLL 96

  Fly   445 TLQTPIIERENNGYLVEDDPLPH----------------SPENFKQQLQ--------QLVEGYER 485
            ...|...::..:..:|..:|.|:                |.|....:|:        :.:..|..
Worm    97 EPTTADQKKRYSNNIVPPEPTPYPITSGEDDFGKTPSRLSNEECPPELKLAPINDRIKYLHYYAE 161

  Fly   486 IPRNALRLNVND--VIGDGRFGEIITG----KVSTNDFARDCTLHVLC---LDDLNGTTQAQLLR 541
            :..|...|:::.  .:|.|.||.|..|    |.|.|. ..:..|.|..   |::.|...|..:..
Worm   162 VEINEEDLDISKGRPLGSGEFGIIRKGFLRSKNSKNK-ETESRLEVAVKSPLNEYNHIQQELIYD 225

  Fly   542 ELRQLSQLKRQEHLLDFYGVSASPDWFYLIFEQQRMSLKRKLVES----------------RLMA 590
            ||:.:..:.:..::|...|        .:...::||.:. :|||:                ..:|
Worm   226 ELKVMCAVGKHPNILALVG--------GITIGEKRMIIS-ELVENGDLLSFLRKNRRNFTIDQLA 281

  Fly   591 PSPRLTSLSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIAR 655
            ..|...||....::.:.:::|..|.||.....|||.|...:|.:..:..::::.||      :||
Worm   282 FEPEKPSLGLVDLVSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKGNMVIRIADFG------LAR 340

  Fly   656 QQ---------------PDHNRWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVAS 705
            :.               |.|  |:|||.: .:...:.:|||||.....:|..:||.:||.|.:..
Worm   341 RHKNKDYYKTQSVDTPLPIH--WMAPESI-DKLLFTQKSDVWSYGVCLYELFSLGKSPYKNVIKY 402

  Fly   706 NQQ------LLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSSCED-VAFGVRQLMTS 760
            :::      :|..:....|.||||:...::|.::..||.|:.:.|::..| :.|..::|.|:
Worm   403 DERDSYCKYVLAYLNEGKRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLDCIEFFEKELKTT 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470
		TyrKc	493..746	CDD:197581	69/298 (23%)
		PTKc	497..750	CDD:270623	69/299 (23%)
old-2	NP_496123.1	PTKc	175..458	CDD:270623	70/301 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810