DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and ver-4

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_509835.2	Gene:	ver-4 / 186632	WormBaseID:	WBGene00006897	Length:	1216	Species:	Caenorhabditis elegans

Alignment Length:	712	Identity:	140/712 - (19%)
Similarity:	262/712 - (36%)	Gaps:	191/712 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 YSTILTKQPGPHHLRISNKTENS--LTLSWNA----YEARKLLLAGGAEAVLPNQLL---DNFLI 177
            |:.:|.|:.....:.:..|..::  :|::.||    :|..|.:.|...|   |:.::   ||  :
Worm   556 YNFVLAKRTDFKCINVKKKKTSTKFITVTSNANKTFHEIEKSVNATKTE---PSDIIFEGDN--V 615

  Fly   178 KAQVLKTYSSLP-----AFPQPEFMVQSTETQFELTDLHPA-TLYN---ISVRAMCKDAQVGQSE 233
            :...:..|.::.     .|..|:.:..:|     ...:||. ..|.   ::||.:..|. .|...
Worm   616 RLTCVVPYGAVEFDVFWKFENPKMLKYTT-----FPAMHPVKDRYKRVILNVRNITIDF-TGTYY 674

  Fly   234 C------GQASIEATTEVGLPSPVPAQPKILSRTDRTVTIELSPIRNDNGPLSKLLVIVEYVDNA 292
            |      .:...|.:..|...||    |.:|:...|::      |...||.:..:...|    |.
Worm   675 CIVKNKEFEHRFETSISVEKVSP----PFLLNNNSRSI------ISASNGQMFDINCKV----NG 725

  Fly   293 LSQPFDAQLLGSWQQAQQDGVPYYIAAELDYDRPEDNRTRRFVVGDGKRYGRFTNKPLDQPDAHV 357
            :..| |.    :|   .:||.||               |:..|:|:.                 :
Worm   726 VPTP-DY----TW---FKDGYPY---------------TKGKVIGNA-----------------L 750

  Fly   358 HISLGLVSTLEGVTKTMYSRGTHDQHVTSLDDFSYATFEKGQSSVVALAVT---CVIFGSCLLLS 419
            |     ||..|.....::.....::..|::|...........||...|.:|   .|:.|  :::|
Worm   751 H-----VSKAEKRDNGIFWCSATNRAGTTIDYIEVKVAGASSSSFFWLFITFFAFVVVG--IVVS 808

  Fly   420 LIAYFYLRYKTCRGRRLTGGNTHEMT--LQTPIIERENNGYLVED--DPLPHSPENFKQQLQQLV 480
            |: :.....|..:...|:..|....|  .|...:..:.|...||:  |.|.:: |:::..|:
Worm   809 LL-WKLFGQKDLKPSELSLNNLKRATDEYQKYTVSEKINNLPVEERIDYLTYN-EDYEIDLE--- 868

  Fly   481 EGYERIPRNALRLNVNDVIGDGRFGEIITG---KVSTNDFARDCTLHVL---CLDDLNGTTQAQL 539
                       .|.:.:.:|.|:||.:..|   ..|:.:|..:..|.|.   ..|..|...|...
Worm   869 -----------NLEILETLGSGQFGIVKKGYLNMASSKNFGFESRLSVAIKSSTDSSNMELQKMF 922

  Fly   540 LRELRQLSQLKRQEHLLDFYGV---SASPDWFYLIFE------------QQRMSLKRKLVE---- 585
            ..||:.:..:.:..::|...|.   :......:::.|            ::|.....:|||
Worm   923 FEELKLMCAIPKHPNVLSLVGAVTKNMEIGELFIVTELIDGGNLREFLRERRDVFANELVEKGYI 987

  Fly   586 --SRLMAPSPRLTSLSEQLVLQWI------------YELASAMNYLSSCQVVHRQLCSHSVFVTS 636
              :.:....|:.....|||::...            .::|:.|::|::...|||.|...:|.::.
Worm   988 FLTNVRENVPKREVEKEQLLIDEFNSLCTSDLLSIGLQIANGMDWLANIPCVHRDLACRNVLISK 1052

  Fly   637 DFKLKLSVFG-------------------PLPYMNIARQQPDHNRWLAPEVLRHQHHHSTRSDVW 682
            ...::::.||                   |||.           ||:..|.:. ....:.:||||
Worm  1053 TKIIRIADFGLAKKHTDKAYYRVRESLDTPLPV-----------RWMPLESIT-DLTFTQKSDVW 1105

  Fly   683 SLACVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSER 744
            |.....:|...||||||.:  ..|..|:|.|:......:|:..:.|:|:::..|||..|.:|
Worm  1106 SYGICLYEIFTLGGTPYPD--CPNFSLVEYIKTGNINKRPSNCHKDVYKIMKMCWQASPDDR 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470	19/109 (17%)
		TyrKc	493..746	CDD:197581	66/310 (21%)
		PTKc	497..750	CDD:270623	65/306 (21%)
ver-4	NP_509835.2	ig	609..679	CDD:278476	14/77 (18%)
		IG_like	611..692	CDD:214653	15/88 (17%)
		IG_like	709..782	CDD:214653	21/121 (17%)
		IGc2	714..772	CDD:197706	17/106 (16%)
		STYKc	870..1175	CDD:214568	66/310 (21%)
		PTKc	874..1176	CDD:270623	65/306 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900