DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Wsck and Pdgfrb

DIOPT Version :10

Sequence 1:NP_733018.1 Gene:Wsck / 318600 FlyBaseID:FBgn0046685 Length:791 Species:Drosophila melanogaster
Sequence 2:NP_001139740.1 Gene:Pdgfrb / 18596 MGIID:97531 Length:1099 Species:Mus musculus


Alignment Length:811 Identity:159/811 - (19%)
Similarity:275/811 - (33%) Gaps:297/811 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 AVLASEKCFCANV-LEPQEQQDEQLCNTRCLAN----KAQYCGGVGVHSYYSTILTKQPGPHHLR 136
            |.|:....:..|| :...:..||:..|...:.|    ..:..|.|.:...:.:        ..||
Mouse   280 AELSDSGTYTCNVSVSVNDHGDEKAINISVIENGYVRLLETLGDVEIAELHRS--------RTLR 336

  Fly   137 ISNKTENSLTLSWNAYEARKLLLAGGAEAVLPNQLLDN-------FLIKAQVLKT-YSSLPAFPQ 193
            :..:.....::.| ..:.|.|..:|..|.||..:.:..       .|::.:|.:. |.::.||.:
Mouse   337 VVFEAYPMPSVLW-LKDNRTLGDSGAGELVLSTRNMSETRYVSELILVRVKVSEAGYYTMRAFHE 400

  Fly   194 PEFMVQSTETQ-------FELTDLHPATLYNISVRAMCKDAQVGQSECGQASIEATTEVGLPSPV 251
            .:.:..|.:.|       .||::.|||.                    |:.:|..... |:|   
Mouse   401 DDEVQLSFKLQVNVPVRVLELSESHPAN--------------------GEQTIRCRGR-GMP--- 441

  Fly   252 PAQPKILSRTDRTV------TIELSPIRNDNGPLSKLLVIVEYVDNALSQPFDAQLLGSWQQAQQ 310
              ||.:...|.|.:      .:..:|:.|.:...|:|...|.:                |::.|:
Mouse   442 --QPNVTWSTCRDLKSRCPRKLSPTPLGNSSKEESQLETNVTF----------------WEEDQE 488

  Fly   311 DGVPYYIAAELDYDRPEDNRTRRFVVGDGKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTKTMY 375
                |.:.:.|        |.|.                :|||       |.:...|:.      
Mouse   489 ----YEVVSTL--------RLRH----------------VDQP-------LSVRCMLQN------ 512

  Fly   376 SRGTHDQHVTSLD---DFSYATFEKGQSSVVALAVTCVIFGSCLLLSLI----AYFYLRYKTCRG 433
            |.|...|.||.:.   .|.....    |:::||.|..||  |.::|.::    ..:.:|:|....
Mouse   513 SMGGDSQEVTVVPHSLPFKVVVI----SAILALVVLTVI--SLIILIMLWQKKPRYEIRWKVIES 571

  Fly   434 RRLTGGNTHEMTLQTPIIERENNGYLVEDDPLPHSPENFKQQLQQLVEGYERIPRNALRLNVNDV 498
               ...:.||.....|:             .||:             :....:||:.|.|  ...
Mouse   572 ---VSSDGHEYIYVDPV-------------QLPY-------------DSTWELPRDQLVL--GRT 605

  Fly   499 IGDGRFGEIITGKVSTNDFARDCTLHVL---------CLDDLNGTTQAQ----LLRELRQLSQLK 550
            :|.|.||:::           :.|.|.|         .:..|..|.::.    |:.||:.:|.|.
Mouse   606 LGSGAFGQVV-----------EATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG 659

  Fly   551 RQEHLLDFYGVSASPDWFYLIFEQ------------------QRMS------------------- 578
            ...::::..|........|:|.|.                  ||.|                   
Mouse   660 PHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQRHSNKHCPPSAELYSNALPVGF 724

  Fly   579 ------------------------------------LKRKLVES-RLMAP-------SP----RL 595
                                                :|...:|| ..|||       :|    |.
Mouse   725 SLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPSAPERTYRA 789

  Fly   596 TSLSEQLVLQWI------YELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIA 654
            |.:::..||.:.      |::|:.|::|:|...|||.|.:.:|.:.....:|:..||      :|
Mouse   790 TLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFG------LA 848

  Fly   655 RQ-QPDHN-----------RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQ 707
            |. ..|.|           :|:|||.: ....::|.|||||...:.||...||||||.. :..|.
Mouse   849 RDIMRDSNYISKGSTFLPLKWMAPESI-FNSLYTTLSDVWSFGILLWEIFTLGGTPYPE-LPMND 911

  Fly   708 QLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQ 738
            |...||:...|.||||:...::|:::..||:
Mouse   912 QFYNAIKRGYRMAQPAHASDEIYEIMQKCWE 942

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WsckNP_733018.1 WSC 42..115 CDD:460348 8/42 (19%)
fn3 130..222 CDD:394996 21/106 (20%)
PTKc 497..750 CDD:270623 79/358 (22%)
PdgfrbNP_001139740.1 ig 36..113 CDD:395002
Ig strand B 49..53 CDD:409353
Ig strand C 59..62 CDD:409353
Ig strand E 82..86 CDD:409353
Ig strand F 96..101 CDD:409353
Ig 211..309 CDD:472250 7/28 (25%)
Ig strand B 230..234 CDD:409353
Ig strand C 243..247 CDD:409353
Ig strand E 273..277 CDD:409353
Ig strand F 287..292 CDD:409353 0/4 (0%)
Ig strand G 302..305 CDD:409353 1/2 (50%)
Ig 313..414 CDD:472250 18/109 (17%)
Ig strand B 333..337 CDD:409353 1/3 (33%)
Ig strand C 346..350 CDD:409353 1/4 (25%)
Ig strand E 378..382 CDD:409353 0/3 (0%)
Ig strand F 392..397 CDD:409353 1/4 (25%)
Ig strand G 405..408 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 562..953 CDD:473864 90/431 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1017..1099
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.