DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and Pdgfrb

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_001139740.1	Gene:	Pdgfrb / 18596	MGIID:	97531	Length:	1099	Species:	Mus musculus

Alignment Length:	811	Identity:	159/811 - (19%)
Similarity:	275/811 - (33%)	Gaps:	297/811 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 AVLASEKCFCANV-LEPQEQQDEQLCNTRCLAN----KAQYCGGVGVHSYYSTILTKQPGPHHLR 136
            |.|:....:..|| :...:..||:..|...:.|    ..:..|.|.:...:.:        ..||
Mouse   280 AELSDSGTYTCNVSVSVNDHGDEKAINISVIENGYVRLLETLGDVEIAELHRS--------RTLR 336

  Fly   137 ISNKTENSLTLSWNAYEARKLLLAGGAEAVLPNQLLDN-------FLIKAQVLKT-YSSLPAFPQ 193
            :..:.....::.| ..:.|.|..:|..|.||..:.:..       .|::.:|.:. |.::.||.:
Mouse   337 VVFEAYPMPSVLW-LKDNRTLGDSGAGELVLSTRNMSETRYVSELILVRVKVSEAGYYTMRAFHE 400

  Fly   194 PEFMVQSTETQ-------FELTDLHPATLYNISVRAMCKDAQVGQSECGQASIEATTEVGLPSPV 251
            .:.:..|.:.|       .||::.|||.                    |:.:|..... |:|
Mouse   401 DDEVQLSFKLQVNVPVRVLELSESHPAN--------------------GEQTIRCRGR-GMP--- 441

  Fly   252 PAQPKILSRTDRTV------TIELSPIRNDNGPLSKLLVIVEYVDNALSQPFDAQLLGSWQQAQQ 310
              ||.:...|.|.:      .:..:|:.|.:...|:|...|.:                |::.|:
Mouse   442 --QPNVTWSTCRDLKSRCPRKLSPTPLGNSSKEESQLETNVTF----------------WEEDQE 488

  Fly   311 DGVPYYIAAELDYDRPEDNRTRRFVVGDGKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTKTMY 375
                |.:.:.|        |.|.                :|||       |.:...|:.
Mouse   489 ----YEVVSTL--------RLRH----------------VDQP-------LSVRCMLQN------ 512

  Fly   376 SRGTHDQHVTSLD---DFSYATFEKGQSSVVALAVTCVIFGSCLLLSLI----AYFYLRYKTCRG 433
            |.|...|.||.:.   .|.....    |:::||.|..||  |.::|.::    ..:.:|:|....
Mouse   513 SMGGDSQEVTVVPHSLPFKVVVI----SAILALVVLTVI--SLIILIMLWQKKPRYEIRWKVIES 571

  Fly   434 RRLTGGNTHEMTLQTPIIERENNGYLVEDDPLPHSPENFKQQLQQLVEGYERIPRNALRLNVNDV 498
               ...:.||.....|:             .||:             :....:||:.|.|  ...
Mouse   572 ---VSSDGHEYIYVDPV-------------QLPY-------------DSTWELPRDQLVL--GRT 605

  Fly   499 IGDGRFGEIITGKVSTNDFARDCTLHVL---------CLDDLNGTTQAQ----LLRELRQLSQLK 550
            :|.|.||:::           :.|.|.|         .:..|..|.::.    |:.||:.:|.|.
Mouse   606 LGSGAFGQVV-----------EATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG 659

  Fly   551 RQEHLLDFYGVSASPDWFYLIFEQ------------------QRMS------------------- 578
            ...::::..|........|:|.|.                  ||.|
Mouse   660 PHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQRHSNKHCPPSAELYSNALPVGF 724

  Fly   579 ------------------------------------LKRKLVES-RLMAP-------SP----RL 595
                                                :|...:|| ..|||       :|    |.
Mouse   725 SLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPSAPERTYRA 789

  Fly   596 TSLSEQLVLQWI------YELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIA 654
            |.:::..||.:.      |::|:.|::|:|...|||.|.:.:|.:.....:|:..||      :|
Mouse   790 TLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFG------LA 848

  Fly   655 RQ-QPDHN-----------RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQ 707
            |. ..|.|           :|:|||.: ....::|.|||||...:.||...||||||.. :..|.
Mouse   849 RDIMRDSNYISKGSTFLPLKWMAPESI-FNSLYTTLSDVWSFGILLWEIFTLGGTPYPE-LPMND 911

  Fly   708 QLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQ 738
            |...||:...|.||||:...::|:::..||:
Mouse   912 QFYNAIKRGYRMAQPAHASDEIYEIMQKCWE 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068	8/42 (19%)
		fn3	130..222	CDD:278470	21/106 (20%)
		TyrKc	493..746	CDD:197581	80/362 (22%)
		PTKc	497..750	CDD:270623	79/358 (22%)
Pdgfrb	NP_001139740.1	ig	36..113	CDD:278476
		IG_like	221..309	CDD:214653	7/28 (25%)
		Ig	227..311	CDD:299845	7/30 (23%)
		Ig	313..414	CDD:299845	18/109 (17%)
		IG	334..412	CDD:214652	15/78 (19%)
		PKc_like	562..953	CDD:304357	90/431 (21%)
		Pkinase_Tyr	600..953	CDD:285015	81/364 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1017..1099
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900