DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and ver-3

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_509836.1	Gene:	ver-3 / 181289	WormBaseID:	WBGene00006896	Length:	1227	Species:	Caenorhabditis elegans

Alignment Length:	775	Identity:	172/775 - (22%)
Similarity:	258/775 - (33%)	Gaps:	285/775 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 PHHLRISNKTENSLTLSWNAYEARKLLLAGG---AEAVLPNQLLD------NFLIKAQVLKTYSS 187
            |||.:.|..||:         |..|::..|.   ...|.|   ||      ::..:.......||
Worm   565 PHHEKSSKATES---------EPSKIIYEGDNVKLTCVFP---LDSDDWSVSWRFENSKSSDISS 617

  Fly   188 LPAFPQPEFMVQSTETQFELTDLHPATLYNISVRAMCKDAQVGQSECGQASIEATTEVGLPSPVP 252
            :|...:.|....|......|.|:  .|.:..:...:.|      :|..:..:|.:.:|
Worm   618 IPTTTETEIKQYSKHLILNLRDV--TTSFTGTYTCVVK------NEDSEKLLETSIDV------- 667

  Fly   253 AQPKILSRTDRTVTIELSPIRNDNGPLSKLLVIVEYVDNALSQPFD--AQLLGSWQQAQQ---DG 312
               |.:|:...|            |..|..:|||:|     .|.|:  ..:.|:.....|   ||
Worm   668 ---KAISKPSIT------------GGNSNAVVIVDY-----DQYFEINCNMTGTPPPVYQWFKDG 712

  Fly   313 VPYYIAAELDYD---------RPEDNRTRRFVVGDGKRYGRFTNKPLDQPDAHVHISLGLVSTLE 368
            .||   ...|.|         |.||         ||:.:...||:..|:.::   |.:.:.:..:
Worm   713 NPY---THGDVDGSILRVSRARGED---------DGEFHCLATNRAGDKLNS---IEVQVNNAPK 762

  Fly   369 GVTKTMYSRGTHDQHVTSLDDFSYATFEKGQSSVVALAVTCVIFGSCLLLSLIAYFYLRYKTCRG 433
            |                ||  |.|        ..:||         .||:|:||.|.|..|....
Worm   763 G----------------SL--FFY--------WFLAL---------LLLISIIAVFLLTCKLRAS 792

  Fly   434 RRLT------------------GGNTHEMTLQTPIIERE-----NNGYLVEDDPLPHSPENFKQQ 475
            .|||                  .|...|.....|:.||.     ||.|  |.||
Worm   793 NRLTKQKDIALNTLYETMIKHQAGPLPEEMKDLPVEERTYYLPYNNDY--EIDP----------- 844

  Fly   476 LQQLVEGYERIPRNALRLNVNDVIGDGRFGEIITG---------------------KVSTNDFAR 519
                           :.|.:.:.||.|.||.:..|                     |.|||.|..
Worm   845 ---------------VNLEILNPIGSGHFGVVKKGLLGMAYPKSKIESKTRLPVAVKSSTNPFNV 894

  Fly   520 DC------TLHVLCLDDLN------------GTTQAQL-----------LRELRQ------LSQL 549
            :.      .|.|:|....|            ...|.||           |||..|      :::|
Worm   895 ELQKMMAEELKVMCAIPKNPNVLALIGAVTKNMRQGQLYIVTEFIDGGNLREFLQAHRNTFINEL 959

  Fly   550 KRQEHLLDFYGVSASPDWFYLIFEQQRMSLKRKLVE--------SRLMAPSPRLTSLSEQLVLQW 606
            ...||:        ..|..||:    ..|:|:|:.:        :||:...|.....|:.|.:.
Worm   960 VEDEHV--------PVDDSYLV----PNSVKKKIYKFDEKLGEGTRLLVEDPDALCTSDLLSIG- 1011

  Fly   607 IYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFG-------------------PLPYMN 652
             .::|..|.:|:....|||.|...:|.:|....::::.||                   |||.
Worm  1012 -LQIAKGMAWLADVPCVHRDLACRNVLITKTKIVRIADFGLSKKHTNKTYYRTKKSKDTPLPV-- 1073

  Fly   653 IARQQPDHNRWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAV 717
                     ||:..|.: .:...:.:|||||.....:|...||||||.|....|  ::|.||...
Worm  1074 ---------RWMPLECI-EEFKFTQKSDVWSFGICLYEIFTLGGTPYPNCDTFN--VIEFIRNGN 1126

  Fly   718 RPAQPAYVYGDLYQLLLNCWQLEPSERSSCED-VAFGVRQLMTSPRHALSFDRVAGGLDT 776
            |..||.|.:.::|:|:..|||..|.:|.:..| :.|....:..|....|  :||...|.|
Worm  1127 RNKQPEYCHDEIYELMKVCWQFNPKDRPTFNDCITFFENHMRDSSSQFL--ERVENMLHT 1184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470	21/98 (21%)
		TyrKc	493..746	CDD:197581	82/335 (24%)
		PTKc	497..750	CDD:270623	82/336 (24%)
ver-3	NP_509836.1	IG	242..>313	CDD:214652
		IG_like	578..667	CDD:214653	17/99 (17%)
		Ig_3	578..654	CDD:290638	15/86 (17%)
		I-set	673..757	CDD:254352	26/115 (23%)
		IGc2	692..747	CDD:197706	16/66 (24%)
		STYKc	847..1163	CDD:214568	83/343 (24%)
		PTKc	851..1164	CDD:270623	83/340 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900