Protein Alignment Wsck and ver-3

DIOPT Version :10

• Sequence 1: NP_733018.1
• Gene: Wsck / 318600
• FlyBaseID: FBgn0046685
• Length: 791
• Species: Drosophila melanogaster
• Sequence 2: NP_509836.1
• Gene: ver-3 / 181289
• WormBaseID: WBGene00006896
• Length: 1227
• Species: Caenorhabditis elegans
• Alignment Length: 775
• Identity: 172/775 - (22%)
• Similarity: 258/775 - (33%)
• Gaps: 285/775 - (36%)

  Fly   132 PHHLRISNKTENSLTLSWNAYEARKLLLAGG---AEAVLPNQLLD------NFLIKAQVLKTYSS 187
            |||.:.|..||:         |..|::..|.   ...|.|   ||      ::..:.......||
 Worm   565 PHHEKSSKATES---------EPSKIIYEGDNVKLTCVFP---LDSDDWSVSWRFENSKSSDISS 617

  Fly   188 LPAFPQPEFMVQSTETQFELTDLHPATLYNISVRAMCKDAQVGQSECGQASIEATTEVGLPSPVP 252
            :|...:.|....|......|.|:  .|.:..:...:.|      :|..:..:|.:.:|
 Worm   618 IPTTTETEIKQYSKHLILNLRDV--TTSFTGTYTCVVK------NEDSEKLLETSIDV------- 667

  Fly   253 AQPKILSRTDRTVTIELSPIRNDNGPLSKLLVIVEYVDNALSQPFD--AQLLGSWQQAQQ---DG 312
               |.:|:...|            |..|..:|||:|     .|.|:  ..:.|:.....|   ||
 Worm   668 ---KAISKPSIT------------GGNSNAVVIVDY-----DQYFEINCNMTGTPPPVYQWFKDG 712

  Fly   313 VPYYIAAELDYD---------RPEDNRTRRFVVGDGKRYGRFTNKPLDQPDAHVHISLGLVSTLE 368
            .||   ...|.|         |.||         ||:.:...||:..|:.::   |.:.:.:..:
 Worm   713 NPY---THGDVDGSILRVSRARGED---------DGEFHCLATNRAGDKLNS---IEVQVNNAPK 762

  Fly   369 GVTKTMYSRGTHDQHVTSLDDFSYATFEKGQSSVVALAVTCVIFGSCLLLSLIAYFYLRYKTCRG 433
            |                ||  |.|        ..:||         .||:|:||.|.|..|....
 Worm   763 G----------------SL--FFY--------WFLAL---------LLLISIIAVFLLTCKLRAS 792

  Fly   434 RRLT------------------GGNTHEMTLQTPIIERE-----NNGYLVEDDPLPHSPENFKQQ 475
            .|||                  .|...|.....|:.||.     ||.|  |.||
 Worm   793 NRLTKQKDIALNTLYETMIKHQAGPLPEEMKDLPVEERTYYLPYNNDY--EIDP----------- 844

  Fly   476 LQQLVEGYERIPRNALRLNVNDVIGDGRFGEIITG---------------------KVSTNDFAR 519
                           :.|.:.:.||.|.||.:..|                     |.|||.|..
 Worm   845 ---------------VNLEILNPIGSGHFGVVKKGLLGMAYPKSKIESKTRLPVAVKSSTNPFNV 894

  Fly   520 DC------TLHVLCLDDLN------------GTTQAQL-----------LRELRQ------LSQL 549
            :.      .|.|:|....|            ...|.||           |||..|      :::|
 Worm   895 ELQKMMAEELKVMCAIPKNPNVLALIGAVTKNMRQGQLYIVTEFIDGGNLREFLQAHRNTFINEL 959

  Fly   550 KRQEHLLDFYGVSASPDWFYLIFEQQRMSLKRKLVE--------SRLMAPSPRLTSLSEQLVLQW 606
            ...||:        ..|..||:    ..|:|:|:.:        :||:...|.....|:.|.:.
 Worm   960 VEDEHV--------PVDDSYLV----PNSVKKKIYKFDEKLGEGTRLLVEDPDALCTSDLLSIG- 1011

  Fly   607 IYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFG-------------------PLPYMN 652
             .::|..|.:|:....|||.|...:|.:|....::::.||                   |||.
 Worm  1012 -LQIAKGMAWLADVPCVHRDLACRNVLITKTKIVRIADFGLSKKHTNKTYYRTKKSKDTPLPV-- 1073

  Fly   653 IARQQPDHNRWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAV 717
                     ||:..|.: .:...:.:|||||.....:|...||||||.|....|  ::|.||...
 Worm  1074 ---------RWMPLECI-EEFKFTQKSDVWSFGICLYEIFTLGGTPYPNCDTFN--VIEFIRNGN 1126

  Fly   718 RPAQPAYVYGDLYQLLLNCWQLEPSERSSCED-VAFGVRQLMTSPRHALSFDRVAGGLDT 776
            |..||.|.:.::|:|:..|||..|.:|.:..| :.|....:..|....|  :||...|.|
 Worm  1127 RNKQPEYCHDEIYELMKVCWQFNPKDRPTFNDCITFFENHMRDSSSQFL--ERVENMLHT 1184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:460348
		fn3	130..222	CDD:394996	21/98 (21%)
		PTKc	497..750	CDD:270623	82/336 (24%)
ver-3	NP_509836.1	IG_like	242..>313	CDD:214653
		IG_like	578..667	CDD:214653	17/99 (17%)
		Ig strand B	588..592	CDD:409353	0/3 (0%)
		Ig strand C	602..606	CDD:409353	0/3 (0%)
		Ig strand E	633..637	CDD:409353	0/3 (0%)
		Ig strand F	647..652	CDD:409353	0/4 (0%)
		Ig_3	672..744	CDD:464046	22/100 (22%)
		PTKc	851..1164	CDD:270623	83/340 (24%)