DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and kin-15

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_741035.2	Gene:	kin-15 / 174498	WormBaseID:	WBGene00002199	Length:	488	Species:	Caenorhabditis elegans

Alignment Length:	472	Identity:	106/472 - (22%)
Similarity:	192/472 - (40%)	Gaps:	109/472 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 MYSRGTHDQ-----HVTS-LDDFSYATFEKGQSSVVALAVTCVIFGSCLLLSLIAYFYLRYKTCR 432
            :||..|.:.     |::| :.:..|    ..|..::.:.: |::.   :|:|:|.|...||..
Worm    22 VYSNSTFESFTENPHISSQISNVLY----MDQMFIIYILI-CILL---ILISVIVYLSKRYSQ-- 76

  Fly   433 GRRLTGGNTHEMTLQTPIIERENNGY----------LVEDDPLPHSPENFKQQLQQLVEGYERIP 487
             :.:...:........|.:..::|.|          :.|:.|:      .|:.:.:.:|..|..|
Worm    77 -QMMQSSDNITNRRSNPEVRNKSNIYDLPPLLDVTSVNEETPI------VKRPINERIENLEFDP 134

  Fly   488 R---NALRLNVN-DVIGDGRFGEIITGKVS--TNDFARDCTLHVLCL-----DDLNGTTQAQLLR 541
            |   :..:|.:: |.:|.|.|||:..|.:|  |::...| ||..|.:     :|.....|.:::.
Worm   135 RFEIDQAKLEISEDKLGSGFFGEVCYGLLSMRTSNTETD-TLQKLSVAVKQSNDPTQENQEKMIE 198

  Fly   542 -ELRQLSQLKRQEHLLDFYGV----SASPDWFYLI-----------FEQQRMSLKRKLVESR--- 587
             |.:.:..:.|..::|...|.    |.|.....::           .|:::...|.:||..:
Worm   199 DETKLMCAIGRNPNILAIIGAVTANSGSARNLLIVEFVECGDLLKFLEEKKSIFKDELVYEKNGY 263

  Fly   588 LMAPSPR-----------------LTSLSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVT 635
            |:..|.|                 |.||....:|.:.|::|..|.||:|...|||.|...:|.:.
Worm   264 LLPKSIRRKTYMFNENEDDVIEESLDSLCTSDLLSFSYQIAEGMEYLASIPCVHRDLALRNVLLN 328

  Fly   636 SDFKLKLSVFGPLPYMNIARQ--------------QPDHNRWLAPEVLRHQHHHSTRSDVWSLAC 686
            .:..::::.||      :||:              .|...||:||||:| :...:.:|||||...
Worm   329 KNKTIRIADFG------LARKYQVDGYYRITKGVGTPMPARWMAPEVMR-EGKCTEKSDVWSYGV 386

  Fly   687 VAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSER---SSCE 748
            ..:|..:||..||:|  .||..:.|.:....:...|.|.:..:|..:...|..:.:.|   |.|
Worm   387 SLYEMFSLGELPYSN--VSNSDVFEHVVQGNQLPMPQYCHPKMYDRMKQFWNFDATFRPSFSKC- 448

  Fly   749 DVAFGVRQLMTSPRHAL 765
             |.|....|..|..:.|
Worm   449 -VEFFEEHLSVSATNLL 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470
		TyrKc	493..746	CDD:197581	75/313 (24%)
		PTKc	497..750	CDD:270623	76/312 (24%)
kin-15	NP_741035.2	STYKc	147..452	CDD:214568	77/316 (24%)
kin-15	NP_741035.2	PTKc	148..453	CDD:270623	78/316 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3801
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000