DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and Kit

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_001116205.1	Gene:	Kit / 16590	MGIID:	96677	Length:	979	Species:	Mus musculus

Alignment Length:	891	Identity:	163/891 - (18%)
Similarity:	274/891 - (30%)	Gaps:	356/891 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 QLCNTRCLANKAQYCGGVGVHSYYSTILTKQPGPHHLRISNKTENSLTLSWNAYEARKLLLAGGA 163
            :|| .||.|.:    .|..:||...|:        .:|.:.|....:::.    |...||..|
Mouse   182 RLC-VRCAAQR----DGTWLHSDKFTL--------KVRAAIKAIPVVSVP----ETSHLLKKG-- 227

  Fly   164 EAVLPNQLLDNFLIKAQVLKTYSSLPAF-----PQPEFMVQSTETQFELTDLH---PATLYNISV 220
                     |.|.:...:....:|:.:.     |||:.:.|.....:...|.:   ..||...|.
Mouse   228 ---------DTFTVVCTIKDVSTSVNSMWLKMNPQPQHIAQVKHNSWHRGDFNYERQETLTISSA 283

  Fly   221 RA------MCKDAQVGQSECGQASIEATTEV---GLPSPVPAQPKILSRTDRTVTIELSPIRN-- 274
            |.      ||    ...:..|.|::..|.:|   |.                   |.:||::|
Mouse   284 RVDDSGVFMC----YANNTFGSANVTTTLKVVEKGF-------------------INISPVKNTT 325

  Fly   275 ------DNGPLSKLLVIVEYVDNALSQPFDAQLLGSWQQAQQDGVPYYIAAELDYDRPEDNRTRR 333
                  :|..|     :|||  .|..:|...|    |               :..:|...|:.:.
Mouse   326 VFVTDGENVDL-----VVEY--EAYPKPEHQQ----W---------------IYMNRTSANKGKD 364

  Fly   334 FVVGDGKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTKTMYSRGTHDQHVTSLDDFSYATFE-- 396
            :|..|.|...|:.|:          :.|..:...||        ||:...|::.|..:..||.
Mouse   365 YVKSDNKSNIRYVNQ----------LRLTRLKGTEG--------GTYTFLVSNSDASASVTFNVY 411

  Fly   397 --------------KGQSSVVALA-------------------------------VTCVIFGSCL 416
                          .|....||..                               |:...||..:
Mouse   412 VNTKPEILTYDRLINGMLQCVAEGFPEPTIDWYFCTGAEQRCTTPVSPVDVQVQNVSVSPFGKLV 476

  Fly   417 LLSLIAYFYLRYK---TCRGRRLTG-----------GNTHEM----TLQTPII------------ 451
            :.|.|.....|:.   .|:.....|           ||..|.    ||.||::
Mouse   477 VQSSIDSSVFRHNGTVECKASNDVGKSSAFFNFAFKGNNKEQIQAHTLFTPLLIGFVVAAGAMGI 541

  Fly   452 -----------------------ERENNGYLVEDD---PLPHSPENFKQQLQQLVEGYERIPRNA 490
                                   |...|.|:..|.   |..|..|               .|||
Mouse   542 IVMVLTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWE---------------FPRN- 590

  Fly   491 LRLNVNDVIGDGRFGEIITGKVSTNDFARDCTLHVLCLDDLNGTTQAQLLR-------------E 542
             ||:....:|.|.||:::           :.|.:.|...|...|...::|:             |
Mouse   591 -RLSFGKTLGAGAFGKVV-----------EATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSE 643

  Fly   543 LRQLSQLKRQEHLLDFYG-----------------------VSASPDWFYLIFEQQRMSLKRKLV 584
            |:.||.|....::::..|                       :....|.|  ||.:|....:..|.
Mouse   644 LKVLSYLGNHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDSF--IFSKQEEQAEAALY 706

  Fly   585 ESRLMAPSPRLTSLSEQL----------------------------------------------V 603
            ::.|.:..|...|.:|.:                                              :
Mouse   707 KNLLHSTEPSCDSSNEYMDMKPGVSYVVPTKTDKRRSARIDSYIERDVTPAIMEDDELALDLDDL 771

  Fly   604 LQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQ-QPDHN------ 661
            |.:.|::|..|.:|:|...:||.|.:.::.:|.....|:..||      :||. :.|.|
Mouse   772 LSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG------LARDIRNDSNYVVKGN 830

  Fly   662 -----RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQ 721
                 :|:|||.: ....::..|||||.....||..:||.:||. .:..:.:..:.|:...|...
Mouse   831 ARLPVKWMAPESI-FSCVYTFESDVWSYGIFLWELFSLGSSPYP-GMPVDSKFYKMIKEGFRMVS 893

  Fly   722 PAYVYGDLYQLLLNCWQLEPSERSSCEDVAFGV-RQLMTSPRHALS 766
            |.:...::|.::..||..:|.:|.:.:.|...: :|:..|.:|..|
Mouse   894 PEHAPAEMYDVMKTCWDADPLKRPTFKQVVQLIEKQISDSTKHIYS 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068	5/15 (33%)
		fn3	130..222	CDD:278470	17/99 (17%)
		TyrKc	493..746	CDD:197581	66/346 (19%)
		PTKc	497..750	CDD:270623	65/346 (19%)
Kit	NP_001116205.1	ig	217..308	CDD:278476	20/109 (18%)
		IG_like	221..310	CDD:214653	20/103 (19%)
		Ig4_SCFR	314..414	CDD:143268	30/162 (19%)
		IG_like	325..412	CDD:214653	25/130 (19%)
		Ig	427..501	CDD:299845	10/73 (14%)
		PTKc_Kit	556..930	CDD:270682	78/411 (19%)
		Important for interaction with phosphotyrosine-binding proteins. /evidence=ECO:0000250	571..573		1/1 (100%)
		Pkinase_Tyr	592..926	CDD:285015	67/354 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900