Protein Alignment Wsck and CSF1R

DIOPT Version :10

• Sequence 1: NP_733018.1
• Gene: Wsck / 318600
• FlyBaseID: FBgn0046685
• Length: 791
• Species: Drosophila melanogaster
• Sequence 2: NP_005202.2
• Gene: CSF1R / 1436
• HGNCID: 2433
• Length: 972
• Species: Homo sapiens
• Alignment Length: 778
• Identity: 156/778 - (20%)
• Similarity: 263/778 - (33%)
• Gaps: 280/778 - (35%)

  Fly   111 QYCGGVGVHSYYSTILTKQPGPHHLRISNKTENSLTLSWNAYEARKLLLAGGAEAVLPNQLLDNF 175
            |:.|.      ||.:.:...|.|          |.::.:...|:..|.|:.....:....:.:..
Human   271 QHAGN------YSCVASNVQGKH----------STSMFFRVVESAYLNLSSEQNLIQEVTVGEGL 319

  Fly   176 LIKAQVLKTYSSLPAF------------PQPEFMVQSTETQFELTDLHPATLYNISVRAMCKDAQ 228
            .:|..| :.|..|..|            |:|:....:|:..:..|       :.:|:      .:
Human   320 NLKVMV-EAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHT-------FTLSL------PR 370

  Fly   229 VGQSECGQASIEATTEVGLPSPVPAQPKILSRTDRTVTIELSPIR------------NDNGPLSK 281
            :..||.|:.|..|....|.               |.:|.||: :|            |.:|.|
Human   371 LKPSEAGRYSFLARNPGGW---------------RALTFELT-LRYPPEVSVIWTFINGSGTL-- 417

  Fly   282 LLVIVEYVDNALSQP--------------FDAQLLGSWQQAQQDGVPYYIAAE----------LD 322
            |.....|     .||              .:||:|..|    .|..|..::.|          |.
Human   418 LCAASGY-----PQPNVTWLQCSGHTDRCDEAQVLQVW----DDPYPEVLSQEPFHKVTVQSLLT 473

  Fly   323 YDRPEDNRT----RRFVVGDGKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTKTMYSRGTHDQH 383
            .:..|.|:|    ....||.|..             |.:.||.|                   .|
Human   474 VETLEHNQTYECRAHNSVGSGSW-------------AFIPISAG-------------------AH 506

  Fly   384 VTSLDDFSYATFEKGQSSVVALAVTCVIFGSCLLLSLIAYFYLRYKTCRGRRLTGGNTHEMTLQT 448
            ....|:|.:          ..:.|.|:...:.|||.|:...| :||          ...:..::.
Human   507 THPPDEFLF----------TPVVVACMSIMALLLLLLLLLLY-KYK----------QKPKYQVRW 550

  Fly   449 PIIER-ENNGY-LVEDDPLPHSPENFKQQLQQLVEGYERIPRNALRLNVNDVIGDGRFGEII--- 508
            .|||. |.|.| .::...||::            |.:| .|||  .|.....:|.|.||:::
Human   551 KIIESYEGNSYTFIDPTQLPYN------------EKWE-FPRN--NLQFGKTLGAGAFGKVVEAT 600

  Fly   509 ---TGKVSTNDFARDCTLHVLCLDDLNGTTQAQ----LLRELRQLSQLKRQEHLLDFYGVSASPD 566
               .||       .|..|.| .:..|..|..|.    |:.||:.:|.|.:.|::::..|......
Human   601 AFGLGK-------EDAVLKV-AVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGG 657

  Fly   567 WFYLIFE----------------------------------QQRMSLKRK--------------- 582
            ...:|.|                                  .:.:.|::|
Human   658 PVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDT 722

  Fly   583 LVESRLMAPSPRLTSLSEQ-------------LVLQWIYELASAMNYLSSCQVVHRQLCSHSVFV 634
            .||.|.::.|.. .|.|||             .:|.:..::|..|.:|:|...:||.:.:.:|.:
Human   723 YVEMRPVSTSSN-DSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLL 786

  Fly   635 TSDFKLKLSVFGPLPYMNIARQ-QPDHN-----------RWLAPEVLRHQHHHSTRSDVWSLACV 687
            |:....|:..||      :||. ..|.|           :|:|||.: ....::.:|||||...:
Human   787 TNGHVAKIGDFG------LARDIMNDSNYIVKGNARLPVKWMAPESI-FDCVYTVQSDVWSYGIL 844

  Fly   688 AWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSSCEDV 750
            .||..:||..||. .:..|.:..:.::...:.||||:...::|.::..||.|||:.|.:.:.:
Human   845 LWEIFSLGLNPYP-GILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:460348	1/3 (33%)
		fn3	130..222	CDD:394996	16/103 (16%)
		PTKc	497..750	CDD:270623	74/336 (22%)
CSF1R	NP_005202.2	IG_like	28..85	CDD:214653
		Ig strand B	38..42	CDD:409353
		Ig strand C	55..58	CDD:409353
		Ig strand E	66..71	CDD:409353
		Ig strand F	81..86	CDD:409353
		Ig strand G	94..97	CDD:409353
		IgI_3_CSF-1R	203..295	CDD:409530	7/39 (18%)
		Ig strand A	203..208	CDD:409530
		Ig strand A'	210..216	CDD:409530
		Ig strand B	220..228	CDD:409530
		Ig strand C	234..238	CDD:409530
		Ig strand C'	241..244	CDD:409530
		Ig strand D	248..253	CDD:409530
		Ig strand E	257..265	CDD:409530
		Ig strand F	274..282	CDD:409530	3/13 (23%)
		Ig strand G	285..295	CDD:409530	3/19 (16%)
		IgI_4_SCFR_like	299..400	CDD:409364	22/130 (17%)
		Ig strand A	299..305	CDD:409364	2/5 (40%)
		Ig strand A'	309..314	CDD:409364	0/4 (0%)
		Ig strand B	317..327	CDD:409364	2/10 (20%)
		Ig strand C	331..338	CDD:409364	2/6 (33%)
		Ig strand C'	340..343	CDD:409364	0/2 (0%)
		Ig strand D	347..352	CDD:409364	2/4 (50%)
		Ig strand E	361..370	CDD:409364	2/21 (10%)
		Ig strand F	377..385	CDD:409364	3/7 (43%)
		Ig strand G	388..399	CDD:409364	5/26 (19%)
		Ig_3	401..489	CDD:464046	18/98 (18%)
		Regulatory juxtamembrane domain	542..574		8/43 (19%)
		PTKc_CSF-1R	543..914	CDD:133237	88/396 (22%)
		Activation loop	796..818		6/27 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	918..950