DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and Flt4

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_032055.1	Gene:	Flt4 / 14257	MGIID:	95561	Length:	1363	Species:	Mus musculus

Alignment Length:	800	Identity:	159/800 - (19%)
Similarity:	270/800 - (33%)	Gaps:	289/800 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 VLASEKCFCANVLEPQEQQDEQLCNTRCLANKAQYCGGVGVHSYYSTILTKQPGPHHLRI-SNKT 141
            |.|..||...|    :..|||:|                 ::.|.:||      |....| |..:
Mouse   528 VSAMYKCVVVN----KVGQDERL-----------------IYFYVTTI------PDGFSIESEPS 565

  Fly   142 ENSLTLSWNAYEARKLLLAGGAEAVLPNQLLDNFLIKAQVLKTYSSLPAFPQPEFMVQSTETQFE 206
            |:.|       |.:.:.|:..|         ||:        ||..|..:            :..
Mouse   566 EDPL-------EGQSVRLSCRA---------DNY--------TYEHLRWY------------RLN 594

  Fly   207 LTDLHPA-------TLYNISVRAMCKDAQVGQSECGQASIEATTEVGLPSPVP------------ 252
            |:.||.|       ...|:.:.|...:|.:.::|.|  :..||..:.:|...|
Mouse   595 LSTLHDAQGNPLLLDCKNVHLFATPLEANLEEAEPG--ARHATLSLNIPRVAPEDEGDYVCEVQD 657

  Fly   253 --AQPKILSRTDRTVTIELSPIRNDNGPLSKLLV-------------------IVEYVDNALSQP 296
              :|.|...:...:|....:|....|  |:.|||                   ||.|.|..|.:
Mouse   658 RRSQDKHCHKKYLSVQALEAPRLTQN--LTDLLVNVSDSLEMRCPVAGAHVPSIVWYKDERLLE- 719

  Fly   297 FDAQLLGSWQQAQQDGVPYYIAAELDYDRPEDNR---TRRFVVGDGKRYGRFTNKPLDQPDAHVH 358
                        ::.|:          |..:.|:   .:|....|..||
Mouse   720 ------------KESGI----------DLADSNQRLSIQRVREEDAGRY---------------- 746

  Fly   359 ISLGLVSTLEGVTKTMYS---RGTHDQHVTSLDDFSYATFEKGQSSVVALAVTCVIFGSCLLLSL 420
              |..|...:|...:..|   .|:.|               ||...:|.|..|.||.....:|.|
Mouse   747 --LCSVCNAKGCVNSSASVAVEGSED---------------KGSMEIVILIGTGVIAVFFWVLLL 794

  Fly   421 IAYFYLRYKTCRGRRLTGGNTHEMTLQTPIIERENNGYL-VEDDP--LPHSPENFKQQLQQLVEG 482
            :.:       |..:|             |.......||| :..||  :|     .::|.:.|  .
Mouse   795 LIF-------CNMKR-------------PAHADIKTGYLSIIMDPGEVP-----LEEQCEYL--S 832

  Fly   483 YE----RIPRNALRLNVNDVIGDGRFGEIITGKVSTNDFARDC-TLHVLCLDDLNGTTQAQ---L 539
            |:    ..||.  ||::..|:|.|.||:::.......:....| |:.|..|.:  |.|.::   |
Mouse   833 YDASQWEFPRE--RLHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKE--GATASEHRAL 893

  Fly   540 LRELRQLSQLKRQEHLLDFYGVSASPDWFYLIF----------------------------EQQR 576
            :.||:.|..:....::::..|....|:...::.                            ||:|
Mouse   894 MSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSNFLRVKRDTFNPYAEKSPEQRR 958

  Fly   577 M----------------SLKRKLVESRLMAP-SPRLTSLSEQLVLQWI------------YELAS 612
            .                |..|.|....||.. |.|...|.::....|:            :::|.
Mouse   959 RFRAMVEGAKADRRRPGSSDRALFTRFLMGKGSARRAPLVQEAEDLWLSPLTMEDLVCYSFQVAR 1023

  Fly   613 AMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIAR---QQPDHNR---------WLA 665
            .|.:|:|.:.:||.|.:.::.::....:|:..||      :||   :.||:.|         |:|
Mouse  1024 GMEFLASRKCIHRDLAARNILLSESDIVKICDFG------LARDIYKDPDYVRKGSARLPLKWMA 1082

  Fly   666 PEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYVYGDLY 730
            ||.: ....::|:|||||...:.||..:||.:||. .|..|::..:.::...|...|......:.
Mouse  1083 PESI-FDKVYTTQSDVWSFGVLLWEIFSLGASPYP-GVQINEEFCQRLKDGTRMRAPELATPAIR 1145

  Fly   731 QLLLNCWQLEPSERSSCEDV 750
            .::.:||..:|..|.:..|:
Mouse  1146 HIMQSCWSGDPKARPAFSDL 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068	9/36 (25%)
		fn3	130..222	CDD:278470	18/99 (18%)
		TyrKc	493..746	CDD:197581	69/325 (21%)
		PTKc	497..750	CDD:270623	68/325 (21%)
Flt4	NP_032055.1	IG_like	238..327	CDD:214653
		Ig1_VEGFR	245..329	CDD:143270
		IG_like	341..415	CDD:214653
		Ig	352..418	CDD:299845
		Ig	569..662	CDD:299845	22/130 (17%)
		IG	570..663	CDD:214652	22/123 (18%)
		I-set	678..765	CDD:254352	22/129 (17%)
		IGc2	693..755	CDD:197706	14/102 (14%)
		PKc_like	837..1175	CDD:304357	73/340 (21%)
		Pkinase_Tyr	845..1169	CDD:285015	70/330 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1288..1330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900