DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and Flt3

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_034359.2	Gene:	Flt3 / 14255	MGIID:	95559	Length:	1000	Species:	Mus musculus

Alignment Length:	819	Identity:	159/819 - (19%)
Similarity:	280/819 - (34%)	Gaps:	233/819 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PIWLSSCLVAMCLGLPLGAAVPQEA---PAYYYVGCYTARTDLL------------HESVYAKTP 62
            |:|:....:.:..|..|...:..:|   .:|:.:..|:....::            :::.|
Mouse   268 PLWIRCKAIHVNHGFGLTWELEDKALEEGSYFEMSTYSTNRTMIRILLAFVSSVGRNDTGY---- 328

  Fly    63 QTCIEICEHQGHHYAVLASEKCFCANVLEPQEQQD----EQLC---------NTRC--LANKAQY 112
            .|| ...:|......|...||.| .|....||:.:    |:.|         ..||  :.::|.:
Mouse   329 YTC-SSSKHPSQSALVTILEKGF-INATSSQEEYEIDPYEKFCFSVRFKAYPRIRCTWIFSQASF 391

  Fly   113 -CGGVGVHSYYSTILTK------QPGPHHLRISNKTENSLTLSWNAYEARKLLLAGGAEAVLPNQ 170
             |...|:...||  ::|      :||.:                       :..|...:|.....
Mouse   392 PCEQRGLEDGYS--ISKFCDHKNKPGEY-----------------------IFYAENDDAQFTKM 431

  Fly   171 LLDNFLIKAQVLKTYSSLPA------FPQPEF-MVQSTETQFELTDLHPATLYNISVR-----AM 223
            ...|...|.|||...|:..|      :|.|.: ..:.::.....|:..|..::|....     ..
Mouse   432 FTLNIRKKPQVLANASASQASCSSDGYPLPSWTWKKCSDKSPNCTEEIPEGVWNKKANRKVFGQW 496

  Fly   224 CKDAQVGQSECGQA---------SIEATTE-VGLPSPVPAQPKILSRTDRTVTIELSPIRNDNGP 278
            ...:.:..||.|:.         |:..:.| :.|.||.|. |.|........||.|.
Mouse   497 VSSSTLNMSEAGKGLLVKCCAYNSMGTSCETIFLNSPGPF-PFIQDNISFYATIGLC-------- 552

  Fly   279 LSKLLVIVEYVDNALSQPF--DAQLLGSWQQAQQDGVPYYI-----AAELDYDRPEDNRTRRFVV 336
            |..::|::..:.:...:.|  ::||.........|...:|:     ..:|.::.|.:|.....|:
Mouse   553 LPFIVVLIVLICHKYKKQFRYESQLQMIQVTGPLDNEYFYVDFRDYEYDLKWEFPRENLEFGKVL 617

  Fly   337 GDGKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTKTMYSRGTHDQHVTSLDDFSYATFEKGQSS 401
            |.| .:||..|                 :|..|::||                        |.|.
Mouse   618 GSG-AFGRVMN-----------------ATAYGISKT------------------------GVSI 640

  Fly   402 VVALAVTCVIFGSCLLLSLIAYFYLRYKTCRGR-----RLTGGNTHEMTLQTPIIERENNGYLVE 461
            .||:.:......||...:|::  .|:..|..|.     .|.|.    .||..|:       ||:
Mouse   641 QVAVKMLKEKADSCEKEALMS--ELKMMTHLGHHDNIVNLLGA----CTLSGPV-------YLI- 691

  Fly   462 DDPLPHSPENFKQQLQQLVEGYERIPRNALRLNVNDVIGDGRFGEIITGKVSTNDFARDCTLHVL 526
                      |:......:..|.|..|........::..:..|....|.:..:|
Mouse   692 ----------FEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQAHSN----------- 735

  Fly   527 CLDDLNGTTQAQLLRELRQLSQLKRQEHLLDFYGVSASPDWFYLIFEQQRMSL--KRKLVESRLM 589
              ..:.|:.:.||...|.|||         .|.|        .||..:..:..  :::|.|..
Mouse   736 --SSMPGSREVQLHPPLDQLS---------GFNG--------NLIHSEDEIEYENQKRLAEEE-- 779

  Fly   590 APSPRLTSLSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIA 654
              ...|..|:.:.:|.:.|::|..|.:|.....|||.|.:.:|.||....:|:..||      :|
Mouse   780 --EEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFG------LA 836

  Fly   655 RQQPDHN------------RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQ 707
            |.....:            :|:|||.| .:..::.:|||||...:.||..:||..||. .:..:.
Mouse   837 RDILSDSSYVVRGNARLPVKWMAPESL-FEGIYTIKSDVWSYGILLWEIFSLGVNPYP-GIPVDA 899

  Fly   708 QLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSS 746
            ...:.|::..:..||.|....:|.::.:||..:..:|.|
Mouse   900 NFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPS 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068	18/100 (18%)
		fn3	130..222	CDD:278470	16/103 (16%)
		TyrKc	493..746	CDD:197581	59/266 (22%)
		PTKc	497..750	CDD:270623	60/264 (23%)
Flt3	NP_034359.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..67
		ig	256..346	CDD:278476	12/82 (15%)
		PKc_like	573..950	CDD:304357	98/474 (21%)
		Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of ligand binding. /evidence=ECO:0000250	592..598		1/5 (20%)
		Pkinase_Tyr	611..946	CDD:285015	91/436 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	968..1000
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900