Protein Alignment Wsck and Fgfr4

DIOPT Version :9

• Sequence 1: NP_733018.1
• Gene: Wsck / 318600
• FlyBaseID: FBgn0046685
• Length: 791
• Species: Drosophila melanogaster
• Sequence 2: XP_006517162.3
• Gene: Fgfr4 / 14186
• MGIID: 95525
• Length: 829
• Species: Mus musculus
• Alignment Length: 875
• Identity: 195/875 - (22%)
• Similarity: 295/875 - (33%)
• Gaps: 291/875 - (33%)

  Fly    34 PQEAPAYYYVGCYTARTDLLHESVYAKTPQTCIEICEHQGHHYAVL-----------------AS 81
            |||.      |....|.|.|..|              .|.|.|..:                 ||
Mouse    13 PQEG------GSGAGRCDSLFPS--------------RQAHTYLYVYKRGLALQGTEPGLGCRAS 57

  Fly    82 EKCFCANVLEPQEQ-------QDEQLCNTRCLANKAQYCGGV--GVHSYYSTILTKQPGPHHLRI 137
            |.|. |.:||.|||       |..:||           ||..  |.|.|.........|    |:
Mouse    58 EPCL-APILEQQEQVLTVALGQPVRLC-----------CGRTERGRHWYKEGSRLASAG----RV 106

  Fly   138 ---SNKTENSLTLSWNAYEARKLLLAGGAEAVLPN--QLLDNFLIK------AQVLKTYSSLPAF 191
               ..:.|.:..|..:|  .|.|.||.|:..|:.|  .|:|:.|..      .:.|.:.||...:
Mouse   107 RGWRGRLEIASFLPEDA--GRYLCLARGSMTVVHNLTLLMDDSLTSISNDEDPKTLSSSSSGHVY 169

  Fly   192 PQ--PEFMVQSTETQFELTDLHPATLYNISVRAMC-------------KDAQV--GQSECGQASI 239
            ||  |.:    |..|.....||.....| :|:..|             ||.|.  |::..|...:
Mouse   170 PQQAPYW----THPQRMEKKLHAVPAGN-TVKFRCPAAGNPMPTIHWLKDGQAFHGENRIGGIRL 229

  Fly   240 -EATTEVGLPSPVPAQPKILSRTDRTVTIELS-------------------PIRNDNGPLSKLLV 284
             .....:.:.|.||:     .|...|..:|.|                   ||.....|.:...|
Mouse   230 RHQHWSLVMESVVPS-----DRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAV 289

  Fly   285 IVEYVDNALSQPFDAQLLGSW--------QQAQQDGVPYY--------------------IAAE- 320
            :...|:.......|||....|        .....||.||.                    ::||
Mouse   290 VGSDVELLCKVYSDAQPHIQWLKHVVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAED 354

  Fly   321 -------------LDYDR------PEDNRTRRFVVGDGKRYGRFTNKPLDQPDAHVHISLGLV-- 364
                         |.|..      ||::.|......:    .|:|       |..:::|..||
Mouse   355 AGEYTCLAGNSIGLSYQSAWLTVLPEEDLTWTTATPE----ARYT-------DIILYVSGSLVLL 408

  Fly   365 --STLEGVTKTMYSRGTHDQHVTSLD---------DFSYATFEKGQSSVVALAVTCVIFGSCLLL 418
              ..|.||......||.:.:...::.         .||..:...|:||                |
Mouse   409 VLLLLAGVYHRQVIRGHYSRQPVTIQKLSRFPLARQFSLESRSSGKSS----------------L 457

  Fly   419 SLIAYFYLRYKTCRGRRLTGGN----THEMTLQTPIIERENNGYLVEDDPLPHSPENFKQQLQQL 479
            ||:          ||.||:...    |..:.|..|:            |||...|.:
Mouse   458 SLV----------RGVRLSSSGPPLLTGLVNLDLPL------------DPLWEFPRD-------- 492

  Fly   480 VEGYERIPRNALRLNVNDVIGDGRFGEIITGKVSTNDFAR-DCTLHV---LCLDDLNGTTQAQLL 540
                        ||.:...:|:|.||:::..:....|.:| |.|..|   :..|:.:....|.|:
Mouse   493 ------------RLVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLV 545

  Fly   541 RELRQLSQLKRQEHLLDFYGVSASPDWFYLIFEQQRMSLKRKLVESRLMAPSPRLT--------- 596
            .|:..:..:.|.:::::..||.......|:|.|.......|:.:.:| ..|.|.|:
Mouse   546 SEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRAR-RPPGPDLSPDGPRSSEG 609

  Fly   597 SLSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIAR------ 655
            .||...::...|::|..|.||.|.:.:||.|.:.:|.||.|..:|::.||      :||
Mouse   610 PLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFG------LARGVHHID 668

  Fly   656 --QQPDHNR----WLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIR 714
              ::..:.|    |:|||.| ....::.:|||||...:.||...|||:||.....  ::|...:|
Mouse   669 YYKKTSNGRLPVKWMAPEAL-FDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPV--EELFSLLR 730

  Fly   715 AAVRPAQPAYVYGDLYQLLLNCWQLEPSER 744
            ...|..:|.....:||.|:..||...||:|
Mouse   731 EGHRMERPPNCPSELYGLMRECWHAAPSQR 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068	22/96 (23%)
		fn3	130..222	CDD:278470	27/104 (26%)
		TyrKc	493..746	CDD:197581	75/277 (27%)
		PTKc	497..750	CDD:270623	74/273 (27%)
Fgfr4	XP_006517162.3	IGc2	77..134	CDD:197706	18/73 (25%)
		Ig	184..268	CDD:386229	17/89 (19%)
		Ig3_FGFR-2	291..378	CDD:143266	13/86 (15%)
		PTKc_FGFR4	481..794	CDD:133230	81/322 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810