Protein Alignment Wsck and Fgfr2

DIOPT Version :9

• Sequence 1: NP_733018.1
• Gene: Wsck / 318600
• FlyBaseID: FBgn0046685
• Length: 791
• Species: Drosophila melanogaster
• Sequence 2: NP_034337.2
• Gene: Fgfr2 / 14183
• MGIID: 95523
• Length: 840
• Species: Mus musculus
• Alignment Length: 606
• Identity: 122/606 - (20%)
• Similarity: 229/606 - (37%)
• Gaps: 143/606 - (23%)

  Fly   271 PIRNDNGPLSKLLVI---VEYVDNALSQPFDAQLLGSW--------QQAQQDGVPYYIAAELDYD 324
            ||.....|.:...|:   ||:|....|   |||....|        .:...||:||....:....
Mouse   275 PILQAGLPANASTVVGGDVEFVCKVYS---DAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGV 336

  Fly   325 RPEDNR-----TRRFVVGDGKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTKTMYSRGTHDQHV 384
            ...|..     .|.....|...|......           |:|:  :......|:......::.:
Mouse   337 NTTDKEIEVLYIRNVTFEDAGEYTCLAGN-----------SIGI--SFHSAWLTVLPAPVREKEI 388

  Fly   385 TSLDDFSYATFEKGQSSVVALAVTC--VIFGSCLLLSLIAYFYLRYKTCRGRRLTGGN--THEMT 445
            |:..|:            :.:|:.|  |...:|:::::|   :.|.||...:......  .|::|
Mouse   389 TASPDY------------LEIAIYCIGVFLIACMVVTVI---FCRMKTTTKKPDFSSQPAVHKLT 438

  Fly   446 LQTPI-----IERENNGYLVEDDPLPHSPENFKQ----QLQQLVEGYE-------RIPRNALRLN 494
            .:.|:     :..|::..:..:.||.........    .:...|..||       ..||:  :|.
Mouse   439 KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD--KLT 501

  Fly   495 VNDVIGDGRFGEIITGKVSTNDFARD-----CTLHVLCL-DDLNGTTQAQLLRELRQLSQLKRQE 553
            :...:|:|.||:::..:....|  :|     .|:.|..| ||......:.|:.|:..:..:.:.:
Mouse   502 LGKPLGEGCFGQVVMAEAVGID--KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 564

  Fly   554 HLLDFYGVSASPDWFYLIFEQQRMSLKRKLVESRL-----------MAPSPRLTSLSEQLVLQWI 607
            ::::..|........|:|.|.......|:.:.:|.           ..|..::|...   ::...
Mouse   565 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD---LVSCT 626

  Fly   608 YELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQQPDHN----------- 661
            |:||..|.||:|.:.:||.|.:.:|.||.:..:|::.||      :||   |.|
Mouse   627 YQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG------LAR---DINNIDYYKKTTNG 682

  Fly   662 ----RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQP 722
                :|:|||.| ....::.:|||||...:.||...|||:||.....  ::|.:.::...|..:|
Mouse   683 RLPVKWMAPEAL-FDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV--EELFKLLKEGHRMDKP 744

  Fly   723 AYVYGDLYQLLLNCWQLEPSERSSCEDVAFGVRQLMT-----------------SPRHALSFDRV 770
            .....:||.::.:||...||:|.:.:.:...:.:::|                 ||.:..:....
Mouse   745 TNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLTQPLEQYSPSYPDTRSSC 809

  Fly   771 AGGLDTL--------PPYLPQ 783
            :.|.|::        .|.|||
Mouse   810 SSGDDSVFSPDPMPYEPCLPQ 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470
		TyrKc	493..746	CDD:197581	69/284 (24%)
		PTKc	497..750	CDD:270623	68/284 (24%)
Fgfr2	NP_034337.2	Ig	66..143	CDD:325142
		Ig2_FGFR	183..267	CDD:143265
		Ig3_FGFR-2	290..379	CDD:143266	19/104 (18%)
		PTKc_FGFR2	475..787	CDD:270679	75/330 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810