DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and Flt4

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_446104.2	Gene:	Flt4 / 114110	RGDID:	621737	Length:	1363	Species:	Rattus norvegicus

Alignment Length:	780	Identity:	158/780 - (20%)
Similarity:	270/780 - (34%)	Gaps:	249/780 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 VLASEKCFCANVLEPQEQQDEQLCNTRCLANKAQYCGGVGVHSYYSTILTKQPGPHHLRI-SNKT 141
            |.|..||...|    :..|||:|                 ::.|.:||      |....| |..:
  Rat   528 VSAMYKCVVFN----KVGQDERL-----------------IYFYVTTI------PDGFSIESEPS 565

  Fly   142 ENSLTLSWNAYEARKLLLAGGAEAVLPNQLLDNFLIKAQVLKTYSSLPAFPQPEFMVQSTETQFE 206
            |:.|       |.:.:.|:..|         ||:        ||..|..:            :..
  Rat   566 EDPL-------EGQSVRLSCRA---------DNY--------TYEHLRWY------------RLN 594

  Fly   207 LTDLHPA-------TLYNISVRAMCKDAQVGQSECGQASIEATTEVGLPSPVPAQPKILSRTDRT 264
            |:.||.|       ...|:.:.|...:|.:.::|.|  :..||..:.:|...|       ..:..
  Rat   595 LSTLHDAQGNPLLLDCKNVHLFATPLEANLEEAEPG--ARHATLSLNIPRVAP-------EDEGD 650

  Fly   265 VTIELSPIRNDNGPLSKLLVIVEYVDNALSQPFDAQLL--------GSWQQ------AQQDGVPY 315
            ...|:...||.:....|..:.|:    ||..|...|.|        .|.:.      |....:.:
  Rat   651 YVCEVQDRRNQDKHCHKKYLSVQ----ALEAPRLTQNLTDLLVNVSDSLEMRCPVAGAHVPSIVW 711

  Fly   316 Y-----IAAELDYDRPEDNR---TRRFVVGDGKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTK 372
            |     :..|...|..:.|:   .:|....|..||                  |..|...:|...
  Rat   712 YKDERLLEKESGIDLADSNQRLSIQRVREEDAGRY------------------LCSVCNAKGCVN 758

  Fly   373 TMYS---RGTHDQHVTSLDDFSYATFEKGQSSVVALAVTCVIFGSCLLLSLIAYFYLRYKTCRGR 434
            :..|   .|:.|               ||...:|.|..|.||.....:|.|:.:       |..:
  Rat   759 SSASVAVEGSED---------------KGSMEIVILIGTGVIAVFFWVLLLLIF-------CNMK 801

  Fly   435 RLTGGNTHEMTLQTPIIERENNGYL-VEDDPLPHSPENFKQQLQQLVEGYERIPRNALRLNVNDV 498
            |             |.......||| :..||.....|...:.|...|..:| .||.  ||::..|
  Rat   802 R-------------PAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDVSQWE-FPRE--RLHLGRV 850

  Fly   499 IGDGRFGEIITGKVSTNDFARDC-TLHVLCLDDLNGTTQAQ---LLRELRQLSQLKRQEHLLDFY 559
            :|.|.||:::.......:....| |:.|..|.:  |.|.::   |:.||:.|..:....::::..
  Rat   851 LGHGAFGKVVEASAFGINKGSSCDTVAVKMLKE--GATASEHRALMSELKILIHIGNHLNVVNLL 913

  Fly   560 GVSASPDWFYLIF----------------------------EQQRM----------------SLK 580
            |....|:...::.                            ||:|.                |..
  Rat   914 GACTKPNGPLMVIVEFCKYGNLSNFLRVKRETFDPYAEKSPEQRRRFRAMVEGAKADRRRLGSTD 978

  Fly   581 RKLVESRLM-------APSPR------LTSLSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSV 632
            |.|....||       ||..:      |:.|:.:.::.:.:::|..|.:|:|.:.:||.|.:.::
  Rat   979 RALFTRFLMGKGSARRAPFVQEAEDLWLSPLTMEDLVCYSFQVALGMEFLASRKCIHRDLAARNI 1043

  Fly   633 FVTSDFKLKLSVFGPLPYMNIAR---QQPDHNR---------WLAPEVLRHQHHHSTRSDVWSLA 685
            .::....:|:..||      :||   :.||:.|         |:|||.: ....::|:|||||..
  Rat  1044 LLSESDIVKICDFG------LARDIYKDPDYVRKGSARLPLKWMAPESI-FDKVYTTQSDVWSFG 1101

  Fly   686 CVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSSCEDV 750
            .:.||..:||.:||. .|..|::..:.::...|...|......:..::.:||..:|..|.:..|:
  Rat  1102 VLLWEIFSLGASPYP-GVQINEEFCQRLKDGTRMRAPELATPAIRHIMQSCWSGDPKARPAFSDL 1165

Fly 751 750
Rat 1166 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068	9/36 (25%)
		fn3	130..222	CDD:278470	18/99 (18%)
		TyrKc	493..746	CDD:197581	69/325 (21%)
		PTKc	497..750	CDD:270623	68/325 (21%)
Flt4	NP_446104.2	Ig_2	137..220	CDD:404734
		IgI_VEGFR	230..329	CDD:409448
		Ig strand B	248..252	CDD:409448
		Ig strand C	263..267	CDD:409448
		Ig strand E	293..297	CDD:409448
		Ig strand F	307..312	CDD:409448
		Ig strand G	320..323	CDD:409448
		Ig	331..418	CDD:416386
		Ig strand A	332..337	CDD:409353
		Ig strand A'	342..347	CDD:409353
		Ig strand B	349..360	CDD:409353
		Ig strand C	364..370	CDD:409353
		Ig strand C'	372..375	CDD:409353
		Ig strand D	378..380	CDD:409353
		Ig strand E	382..387	CDD:409353
		Ig strand F	395..403	CDD:409353
		Ig strand G	409..418	CDD:409353
		IG_like	570..663	CDD:214653	24/130 (18%)
		Ig strand B	574..578	CDD:409353	1/3 (33%)
		Ig strand C	587..591	CDD:409353	1/3 (33%)
		Ig strand E	636..640	CDD:409353	0/3 (0%)
		Ig strand F	650..655	CDD:409353	0/4 (0%)
		IGc2	693..755	CDD:197706	12/79 (15%)
		Ig strand B	695..699	CDD:409353	0/3 (0%)
		Ig strand C	708..712	CDD:409353	0/3 (0%)
		Ig strand E	731..735	CDD:409353	0/3 (0%)
		Ig strand F	745..750	CDD:409353	3/22 (14%)
		VEGFR-2_TMD	770..804	CDD:375470	12/68 (18%)
		PKc_like	837..1175	CDD:419665	74/342 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1289..1330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900