DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and PTPRU

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	XP_016855481.1	Gene:	PTPRU / 10076	HGNCID:	9683	Length:	1452	Species:	Homo sapiens

Alignment Length:	821	Identity:	181/821 - (22%)
Similarity:	278/821 - (33%)	Gaps:	192/821 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RPIPIWLSSCLVAMCLGLPLGAAVPQ----------EAPAYYYVGCYTARTDLLHE----SVYAK 60
            ||.|..:|....|..:..|.|.|..:          |...|....|:|....|.:.    |.:.:
Human   369 RPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQ 433

  Fly    61 TPQTCIEICEHQG-HHYAVLASEKCFCANVLEPQEQQDEQLCNTRCLANKAQYCGGVGVHSYYST 124
            |.:.|::  ..|| ..|.:        .|:| |......:|..|.....|.    |..|     |
Human   434 TIRECVK--TEQGVSRYTI--------KNLL-PYRNVHVRLVLTNPEGRKE----GKEV-----T 478

  Fly   125 ILTKQPGPHHLRISNKT----ENSLTLSWNAYEARKLLLAGGAEAVLPNQLLDNFLIKAQVLKTY 185
            ..|.:..|..:...:.|    |:.:.|.|.             |...||.|:..:.|..|.::
Human   479 FQTDEDVPSGIAAESLTFTPLEDMIFLKWE-------------EPQEPNGLITQYEISYQSIE-- 528

  Fly   186 SSLPA--FPQPEFMVQS--TETQFELTDLHPATLYNISVRAMCKDAQVGQSECGQASI-EATTEV 245
            ||.||  .|.|...:..  .||....::|||.|.|..|||     |:.|:. .|||:: |.||.:
Human   529 SSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVR-----ARTGKG-FGQAALTEITTNI 587

  Fly   246 GLPS-PVPAQPKILSRTDRTVTIELSPIRNDNGPLSKLLVIV--EYVDNALSQP-----FDAQLL 302
            ..|| .....|..|..::.|:|:.|.|.:....|:|...|||  |.......:|     |...|
Human   588 SAPSFDYADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPL- 651

  Fly   303 GSWQQAQQDGVPYYIAAELDYDR-PEDNRTRRFVVGDGKRYGRFTNKPLDQPDAHVHISLGLVST 366
             :::.|...|:.:|..|||.... ||   ...|.|||.:.|..|.|.||:...|:: |.....|.
Human   652 -TFEAALARGLVHYFGAELAASSLPE---AMPFTVGDNQTYRGFWNPPLEPRKAYL-IYFQAASH 711

  Fly   367 LEGVTKTMYSRGTHDQHVTSLDDFSYATFEKGQSS----------VVALAVTCVIFGSCLLL--- 418
            |:|.|:....|.........    |....|..|.|          ...|||..::.|:.:::
Human   712 LKGETRLNCIRIARKAACKE----SKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRK 772

  Fly   419 --SLIAYFY-----------LRYKTCRGRRLTGGN---THEMTLQTPIIER------ENNGYLVE 461
              ...||.|           :.|:..:...::..:   |.:.|||..  ||      :.:||...
Human   773 GRDHYAYSYYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQED--ERLGLSFMDTHGYSTR 835

  Fly   462 DDPLPHSPENFKQQLQQLVEGYERIPRNALRLNVNDVIGDGRFGE-IITGKVSTNDFARDCTLHV 525
            .|    .......:...|:.|..|.|             .||.|. ..||::.......|...|:
Human   836 GD----QRSGGVTEASSLLGGSPRRP-------------CGRKGSPYHTGQLHPAVRVADLLQHI 883

  Fly   526 LCLDDLNG----------------TTQAQLLRELRQLSQLKRQEHLLDFYGVSASP--DWF---Y 569
            ..:....|                |.:...::..||........|.:..:.:...|  |:.   |
Human   884 NQMKTAEGYGFKQEYESFFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANY 948

  Fly   570 LIFEQQRMSLKRKLVESRLMAPSPRLTSLSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFV 634
            :.....|....|.........|.|.:.....::|.|   |..|::..::....|.|..||.....
Human   949 IDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQ---EHCSSIVMITKLVEVGRVKCSRYWPE 1010

  Fly   635 TSDFKLKLSVFGPLPYMNIARQQPDHNRWLAPEVLR----HQHHHSTRSDVWSLACVAWECCALG 695
            .||      .:|.:..|.:..:.      ||..|:|    .:..:|.|.:|......||   ...
Human  1011 DSD------TYGDIKIMLVKTET------LAEYVVRTFALERRGYSARHEVRQFHFTAW---PEH 1060

  Fly   696 GTPYANAVASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNC 736
            |.|| :|..    ||..||.......|     |...::::|
Human  1061 GVPY-HATG----LLAFIRRVKASTPP-----DAGPIVIHC 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068	15/77 (19%)
		fn3	130..222	CDD:278470	26/99 (26%)
		TyrKc	493..746	CDD:197581	51/270 (19%)
		PTKc	497..750	CDD:270623	51/266 (19%)
PTPRU	XP_016855481.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11214
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900