DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wsck and tie1

DIOPT Version :9

Sequence 1:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	XP_002931650.3	Gene:	tie1 / 100496664	XenbaseID:	XB-GENE-922217	Length:	1127	Species:	Xenopus tropicalis

Alignment Length:	751	Identity:	157/751 - (20%)
Similarity:	271/751 - (36%)	Gaps:	237/751 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 EFMVQSTETQFELTDLHPATLYNISVRAMCKDAQVGQSECGQASIEATTEVGLPSPVPAQPK-IL 258
            ||.|||    ..|||   ..|:.      |:.:..|    ||.|.:....|.:| |:|.:|. :|
Frog   401 EFAVQS----LTLTD---NGLWE------CRVSTTG----GQDSRKFQVHVKVP-PLPIEPPLLL 447

  Fly   259 SRTDRTVTIELSPIRN--DNGPLSKLL--------------VIVEYVDNALSQ---PFDAQLLGS 304
            .|..:.:|  |||:.|  .:||:..:.              ::|:..:|.:.|   |..:.|:.:
Frog   448 DRRSQQLT--LSPLHNFSGDGPIISIKLHYKPKDNDSPWKNIVVKQKENIILQKLKPVTSYLIRA 510

  Fly   305 WQQAQQDGV-------PYYIAAELDYDRP-----------EDNRTRRF--------VVGDG---- 339
              |..:.|.       |..: .|.|...|           ||..|...        |:|:|
Frog   511 --QLSRPGPGGEGPLGPLAV-METDCQEPTVKPVIKGHAVEDRNTLYISWNLPSTPVIGNGFLLQ 572

  Fly   340 ----------------------KRYGRFTNK--------------------------------PL 350
                                  |.||...||                                |.
Frog   573 IYHPENHLIRQENITSMYVLSRKVYGLHANKEYTLKVLIYHCRNLGPPSDPFVVTIHSKGPSPPK 637

  Fly   351 D---QPDAHVHISLGLVSTLE---GVTK-TMYSR-----------GTHDQHVT--SLDDFSYATF 395
            |   :|.:...|.|..:...:   |:.| |:.||           .|.:|:.|  .:...:.:||
Frog   638 DLRAEPISRDSIKLSWLPPDDPNGGIIKYTVESRPVGIPGEPQWADTENQNQTWHIISGLNASTF 702

  Fly   396 -----------------------------------------EKGQSSVVALAVTCVIFGSC--LL 417
                                                     ..|.|..:.||:...:..:|  ::
Frog   703 YQFRVRANSKVPGEWSLSVQSTAHSLEIGSQPPSMESKNPRPSGSSHQLILAIIGSVSITCFTII 767

  Fly   418 LSLIAYFYLRYKTCRGRRL---TGGNTHEMTLQTPIIERENNGYLVEDDPLPHSPENFKQQLQQL 479
            |:|:|.|.::......||:   ..|:..|..||.      ::|.|.    |...|....:.....
Frog   768 LALLALFCIKKNFFHRRRMFTYQSGSGEETILQF------SSGTLT----LSRRPRPQTEPFSYP 822

  Fly   480 VEGYERIPRNALRLNVNDVIGDGRFGEIITGKVSTNDFARDCTLHVLCLDDLNGTTQAQLLRELR 544
            |..:|.|       ...||||:|.||::|...:..:....:..:.:| .:..:.........||.
Frog   823 VLEWEDI-------KFEDVIGEGNFGQVIKAMIKKDGQKMNAAIKML-KEFASENDHRDFAGELE 879

  Fly   545 QLSQLKRQEHLLDFYGVSASPDWFYLIFEQQRM-SLKRKLVESRLMAPSP-------RLTSLSEQ 601
            .|.:|....::::..|...:..:.|:..|.... :|...|.:||::...|       ..::|:.|
Frog   880 VLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPVFAKEHGTASTLTSQ 944

  Fly   602 LVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQQPDH------ 660
            .:||:..::|..|.|||..|.:||.|.:.:|.|..:...|::.||      ::|.:..:
Frog   945 QLLQFASDVAKGMQYLSEKQFIHRDLAARNVLVGENLVTKIADFG------LSRGEEVYVKKTMG 1003

  Fly   661 ---NRWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQP 722
               .||:|.|.|.:. .::|:|||||...:.||..:||||||.....:  :|.|.:....|..:|
Frog  1004 RLPVRWMAIESLNYS-VYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCA--ELYENLPQGYRMEKP 1065

  Fly   723 AYVYGDLYQLLLNCWQLEPSERSSCEDVAFGVRQLM 758
            .....::|:|:..||:..|.||.....::..:.:::
Frog  1066 RNCDDEVYELMRQCWRDRPYERPPFSQISIQLTRML 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470	9/26 (35%)
		TyrKc	493..746	CDD:197581	70/269 (26%)
		PTKc	497..750	CDD:270623	70/269 (26%)
tie1	XP_002931650.3	IG_like	124..203	CDD:214653
		EGF_CA	<222..247	CDD:238011
		EGF_CA	306..336	CDD:238011
		Ig	341..432	CDD:416386	14/47 (30%)
		Ig strand A	341..345	CDD:409353
		Ig strand A'	351..355	CDD:409353
		Ig strand B	358..367	CDD:409353
		Ig strand C	375..380	CDD:409353
		Ig strand C'	384..386	CDD:409353
		Ig strand D	390..394	CDD:409353
		Ig strand E	397..405	CDD:409353	2/3 (67%)
		Ig strand F	413..421	CDD:409353	2/13 (15%)
		Ig strand G	424..432	CDD:409353	3/7 (43%)
		fn3	448..511	CDD:394996	13/66 (20%)
		FN3	633..724	CDD:238020	15/90 (17%)
		PTKc_Tie1	826..1122	CDD:270671	72/293 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910