DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk22 and Asic4

DIOPT Version :9

Sequence 1:	NP_733051.2	Gene:	ppk22 / 318593	FlyBaseID:	FBgn0051105	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_071570.2	Gene:	Asic4 / 63882	RGDID:	621068	Length:	539	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	116/547 - (21%)
Similarity:	202/547 - (36%)	Gaps:	126/547 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EHNSKGKRKE----------SLGSAFCLDMADLVRNISLQGYNKLLSPDLTLGQRLIWLLVHMAT 76
            |.::|.|.||          :.|.|...|:|......:|.|..:...|.....:|.:|:|. :.|
  Rat    13 EEDAKPKEKEAGDEQSLLGAAQGPAAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWVLA-LLT 76

  Fly    77 TVSLIVVLSLTWEQFVAQSFVTN----LKDPLFPVENVPFPAVSICPNNRISRQAVIQYAEELRL 137
            :::..:..:.:    :|:.::|.    ..||..|.....||||::|..||. |.:.:..|:...|
  Rat    77 SLAAFLYQAAS----LARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRF-RHSALSDADIFHL 136

  Fly   138 -NSPVIRPVEYFLERLRFFREFYTHVGVVVDTDDFITFQTFLDVFGTWNNETFFDTRRIMKMLTP 201
             |...:.|.:         |:.:...|:.....|.:      |:.    |.|......::|
  Rat   137 ANLTGLPPKD---------RDGHRAAGLRYPEPDMV------DIL----NRTGHQLADMLK---- 178

  Fly   202 RCQGFVLKCTVANVEVPCFSKDAFQDSLTMYGPCCTFNMENKLKKRHFKNRLASSELGLKVVLND 266
            .|......|:.:|          |....|.||.|.|||.:   .:....:|......||:::|:.
  Rat   179 SCNFSGHHCSASN----------FSVVYTRYGKCYTFNAD---PQSSLPSRAGGMGSGLEIMLDI 230

  Fly   267 SHVDYFAPILNTN------GYIVMIHNAENYASVYSSNVLEMFPGQGEDSYIAVCARVVDTDDSL 325
            ...:|......||      |..|.||:.|....::.   |......|..:::: |      .:..
  Rat   231 QQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQ---LGFGVSPGFQTFVS-C------QEQR 285

  Fly   326 KSFSPFSRRCYFEYEAQNPIHEQLMNTYSLSYTFPNCITRCRIRSIIALCRCLPFQMPLQLVENL 390
            .::.|   :.:....|::.:.|..:..|| :|:...|..||...:::..|.|....||
  Rat   286 LTYLP---QPWGNCRAESKLREPELQGYS-AYSVSACRLRCEKEAVLQRCHCRMVHMP------- 339

  Fly   391 DGVVYCTLG-HVSCLNQYIFKWRNILTERHIVNGLEREIEEALYCPQCLPSCRDVQY--EVSMSA 452
            .....|... ::.|.:             |.::.|....|...:||   ..|...:|  |:||..
  Rat   340 GNETICPPNIYIECAD-------------HTLDSLGGGSEGPCFCP---TPCNLTRYGKEISMVK 388

  Fly   453 LP---IDNYLATLKLDENNETEFGTDISVLRVYFG-------DPHAQYYIRLLNNTWFEVFSTIG 507
            :|   ...|||  :....|||....:..||.|:|.       :..|.|.:..|       ...:|
  Rat   389 IPNRGSARYLA--RKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSAL-------LGDLG 444

  Fly   508 NIMSIFVGFSMVAIFEILFFVTKYIYK 534
            ..|.:|:|.|::.:.|||    .|||:
  Rat   445 GQMGLFIGASILTLLEIL----DYIYE 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk22	NP_733051.2	ASC	46..527	CDD:279230	104/504 (21%)
Asic4	NP_071570.2	ASC	40..488	CDD:295594	109/520 (21%)
Asic4	NP_071570.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345613
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850